Interplay between pro-inflammatory cytokines and chromatin-remodeling enzymes in the regulation of central nervous system demyelination and repair

A03

Our work suggests that modulating the activity of the enzyme HDAC1/2 could have multiple beneficial effects in the context of MS by decreasing demyelination induced by interleukin (IL-)17 and tumor necrosis factor (TNF), as well as by enhancing the remyelination of lesions. Here we want to study the role of HDAC1/2 and IL-17/TNF signaling and their interplay on myelination and remyelination of the CNS in the context of inflammation. To do so, we will use genetic mouse models as well as human induced pluripotent stem cells (iPSC)-derived neural cells. These are our research questions::

    1. How do IL-17 and TNF signaling in oligodendrocytes and their precursors dictate the process of de- and remyelination?
    2. How do HDAC1/2 influence demyelination in the context of EAE?
    3. How do HDAC1/2 interact with IL-17 signaling?
    4. Can pharmacological activators of HDAC2 be used as a treatment for multiple sclerosis? To elucidate this question, we will use human cells cultured in a microfluidic model of myelination.

 

 

 

 

 

 

 

 

Principal Investigators:

Univ.-Prof. Dr. rer. nat. Ari Waisman
Institut für Molekulare Medizin
Mainz
waisman@uni-mainz.de

Prof. Dr. rer. nat. Claire Jacob
Institut für Entwicklungsbiologie und Neurobiologie
Mainz
cjacob@uni-mainz.de

News

Wed, 22/11/2023
Hybrid seminar on ‘The origins and consequences of multiple slerosis’
Munich. Prof. Lars Fugger from the Nuffield Department of Clinical Neurosciences at the University of Oxford will give a hybrid seminar on ‘The origins and consequences of multiple slerosis’ in the large auditorium at the TranslaTUM in MUNICH. The talk is organized by the TRR 355 and will be streamed via the TRR 355 seminar […]...more
Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
New Date: Neurology Webinar – How much gut needs the brain
Muenster. In January 2024, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, January 24, 2024 Place: Online at zoom. […]...more