A09

Innate immune-regulatory networks are crucial for controlling T-cell activation in MS. By combining access to unique samples with cutting-edge technologies, we aim to investigate immune-regulatory networks of peripheral (blood, lymph node) and CNS associated (cerebrospinal fluid) immune compartments to:

1. 1. understand alterations of these networks during disease initiation and progression in MS
   2. identifying parameters discriminating MS from other neuroinflammatory autoimmune diseases;
   3. exploring the impact of immune-modulating therapies on these networks; and
   4. generating an MS-specific immunological roadmap in distinct compartments as a path for diagnostic, prognostic, and therapeutic signatures.

Principal Investigators:

Univ.-Prof. Prof. h.c. Dr. med. Heinz Wiendl
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
heinz.wiendl@ukmuenster.de

Dr. rer. nat. Catharina Groß
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
catharina.gross@ukmuenster.de