Analysis and therapeutic modifications of innate immune regulatory networks in controlling T-cell activation in MS

A09

Innate immune-regulatory networks are crucial for controlling T-cell activation in MS. By combining access to unique samples with cutting-edge technologies, we aim to investigate immune-regulatory networks of peripheral (blood, lymph node) and CNS associated (cerebrospinal fluid) immune compartments to:

    1. understand alterations of these networks during disease initiation and progression in MS
    2. identifying parameters discriminating MS from other neuroinflammatory autoimmune diseases;
    3. exploring the impact of immune-modulating therapies on these networks; and
    4. generating an MS-specific immunological roadmap in distinct compartments as a path for diagnostic, prognostic, and therapeutic signatures.

 

 

 

 

 

 

 

 

Principal Investigators:

Univ.-Prof. Prof. h.c. Dr. med. Heinz Wiendl
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
heinz.wiendl@ukmuenster.de

Dr. rer. nat. Catharina Groß
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
catharina.gross@ukmuenster.de

News

Thu, 15/09/2022
Photo gallery: Inflammation & Imaging Symposium in the MIC building
Muenster. From September 12th to 14th scientists from Muenster University and their international guests discussed the latest developments in research on inflammation and the imaging of the immune system at the 2nd Inflammation & Imaging Symposium. The annual event is jointly organised by several research networks from Münster, among them the CRC/TRR 128 “Multiple Sclerosis”. […]...more
Tue, 28/06/2022
CRC Retreat in Münster
Muenster. After a long pause, more than 90 participants of the CRC joined in Muenster Factory Hotel to update on the latest developments. We heard the most recent on a selection of the CRC projects and there was also plenty of time for fruitful discussion and socializing in the evening....more
Mon, 23/05/2022
EU Research Council awards Lydia Sorokin Advanced Grant
Münster – The biochemist and Principal investigator of the CRC 128 Prof. Dr. Lydia Sorokin has received the coveted “Advanced Grant” awarded by the European Research Council (ERC). The funding of ca. 2.3 million euros enables the realisation of outstanding research projects. Lydia Sorokin heads the Institute for Physiological Chemistry and Pathobiochemistry at Muenster University. […]...more