Analysis and therapeutic modifications of innate immune regulatory networks in controlling T-cell activation in MS

A09

Innate immune-regulatory networks are crucial for controlling T-cell activation in MS. By combining access to unique samples with cutting-edge technologies, we aim to investigate immune-regulatory networks of peripheral (blood, lymph node) and CNS associated (cerebrospinal fluid) immune compartments to:

    1. understand alterations of these networks during disease initiation and progression in MS
    2. identifying parameters discriminating MS from other neuroinflammatory autoimmune diseases;
    3. exploring the impact of immune-modulating therapies on these networks; and
    4. generating an MS-specific immunological roadmap in distinct compartments as a path for diagnostic, prognostic, and therapeutic signatures.

 

 

 

 

 

 

 

 

Principal Investigators:

Univ.-Prof. Prof. h.c. Dr. med. Heinz Wiendl
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
heinz.wiendl@ukmuenster.de

Dr. rer. nat. Catharina Groß
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
catharina.gross@ukmuenster.de

News

Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
Neurology Webinar – How much gut needs the brain
Muenster. In December 2023, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, December 13, 5:15 p.m. Place: Online at […]...more
Thu, 02/02/2023
3rd Inflammation & Imaging Symposium in Münster, 11-13 September 2023
Application has opened! We cordially invite you to join this international conference and discuss the latest developments in research on inflammation and the imaging of the immune system with us. The symposium is organised by eight research networks from the University of Münster – CRU 342, CRC 1009, CRC 1450, CRC/TR 128, CRC/TR 332, InFlame, […]...more