The role of thr kallikrein-kinin system to functional and structural impairment if network activity in multiple sclerosis


Neuronal connectivity and network functions are important for the understanding of multiple sclerosis and its animal models – particularly ion channels play a key role. We established a combination of electrophysical and behavioural techniques to characterize neuronal properties in multiple sclerosis (MS) disease models in vitro and in vivo. We identified a transient period of increased excitability in the thalamocortical neuronal network in the course of inflammatory and demyelinating events. Preliminary data point to specific K+ channels, cytokines and components of the kallikrein-kinin system (KKS) as modulators of neuronal hyperexcitability in animal models of MS. In this funding period, we aim to investigate how the KKS influences MS pathophysiology and to identify the underlying cellular and neuronal network effects. In addition, we aim to establish components of the KKS as possible human biomarkers for different forms of MS and effector channels of KKS signaling as new potential therapeutic targets. Our central questions are::

    1. Can kininogen and KLKs influence MS pathophysiology and what are their cellular and neuronal network effect?
    2. Are serum kininogen levels influenced by neuronal network functions?
    3. Kininogen depositions are found in active MS lesions in close contact to neurons. Are these depositions influencing their function and thus modify the course of disease?













Principal Investigators:

Prof. Dr. rer. nat. Thomas Budde
Institut für Physiologie I

Dr. med. Kerstin Göbel
Klinik für Neurologie mit Institut für Translationale Neurologie

Univ.-Prof. Dr. med. Dr. rer. nat. Dr. h.c. Sven Meuth
Klinik für Neurologie


Thu, 28/03/2024
Looking back and ahead: SFB/CRC 128 symposium provides new perspectives on MS research
The SFB/CRC 128 Symposium, themed “Multiple sclerosis and related disorders – past, present, and future,” unfolded on April 29th and 30th, 2024, within the historic Castle of Münster University and thus at the center of the city. This symposium garnered significant attendance and served as an exemplary forum to discuss advances in the field, present […]...more
Thu, 15/09/2022
Photo gallery: Inflammation & Imaging Symposium in the MIC building
Muenster. From September 12th to 14th scientists from Muenster University and their international guests discussed the latest developments in research on inflammation and the imaging of the immune system at the 2nd Inflammation & Imaging Symposium. The annual event is jointly organised by several research networks from Münster, among them the CRC/TRR 128 “Multiple Sclerosis”. […]...more
Tue, 28/06/2022
CRC Retreat in Münster
Muenster. After a long pause, more than 90 participants of the CRC joined in Muenster Factory Hotel to update on the latest developments. We heard the most recent on a selection of the CRC projects and there was also plenty of time for fruitful discussion and socializing in the evening....more