Rebalancing cortical neuronal hyperactivity as a new treatment strategy in neuroinflammation

B09

In the previous funding period we discovered a maladaptive cortical network dysregulation linked with anxiety behavior as a pathological mechanism in murine neuroinflammation contributing to initiation of neurodegeneration. We now aim at (1) dissecting the causal relation between brainstem pathology and cortical maladaptive hyperactivity, (2) unravelling the relation of local network dysregulation to brain-wide networks, and (3) pharmacologically modulating cortical hyperexcitability and translating our findings to MS patients. These research questions will be investigated:

    1. Does the modulation of AMPA receptors have an effect in neuroinflammatory disorders?
    2. Does the reversal of anxiety symptoms prevent neurodegeneration?
    3. What’s the relation between local nework dysregulation in relapsing-remitting MS with brain-wide networks?
    4. Is there a causal relation between brainstem pathology and cortical maladaptive hyperactivity?

 

 

 

 

 

Principal Investigators:

Dr. med. Erik Ellwardt
Klinik für Neurologie
Mainz
erik.ellwardt@unimedizin-mainz.de

Prof. Dr. rer. nat. Albrecht Stroh
Institut für Mikroskopische Anatomie und Neurobiologie
Mainz
albrecht.stroh@unimedizin-mainz.de

News

Thu, 15/09/2022
Photo gallery: Inflammation & Imaging Symposium in the MIC building
Muenster. From September 12th to 14th scientists from Muenster University and their international guests discussed the latest developments in research on inflammation and the imaging of the immune system at the 2nd Inflammation & Imaging Symposium. The annual event is jointly organised by several research networks from Münster, among them the CRC/TRR 128 “Multiple Sclerosis”. […]...more
Tue, 28/06/2022
CRC Retreat in Münster
Muenster. After a long pause, more than 90 participants of the CRC joined in Muenster Factory Hotel to update on the latest developments. We heard the most recent on a selection of the CRC projects and there was also plenty of time for fruitful discussion and socializing in the evening....more
Mon, 23/05/2022
EU Research Council awards Lydia Sorokin Advanced Grant
Münster – The biochemist and Principal investigator of the CRC 128 Prof. Dr. Lydia Sorokin has received the coveted “Advanced Grant” awarded by the European Research Council (ERC). The funding of ca. 2.3 million euros enables the realisation of outstanding research projects. Lydia Sorokin heads the Institute for Physiological Chemistry and Pathobiochemistry at Muenster University. […]...more