Rebalancing cortical neuronal hyperactivity as a new treatment strategy in neuroinflammation

B09

In the previous funding period we discovered a maladaptive cortical network dysregulation linked with anxiety behavior as a pathological mechanism in murine neuroinflammation contributing to initiation of neurodegeneration. We now aim at (1) dissecting the causal relation between brainstem pathology and cortical maladaptive hyperactivity, (2) unravelling the relation of local network dysregulation to brain-wide networks, and (3) pharmacologically modulating cortical hyperexcitability and translating our findings to MS patients. These research questions will be investigated:

    1. Does the modulation of AMPA receptors have an effect in neuroinflammatory disorders?
    2. Does the reversal of anxiety symptoms prevent neurodegeneration?
    3. What’s the relation between local nework dysregulation in relapsing-remitting MS with brain-wide networks?
    4. Is there a causal relation between brainstem pathology and cortical maladaptive hyperactivity?

 

 

 

 

 

Principal Investigators:

Prof. Dr. rer. nat. Albrecht Stroh
Institut für Mikroskopische Anatomie und Neurobiologie
Mainz
albrecht.stroh@unimedizin-mainz.de

Univ.-Prof. Dr. med. Frauke Zipp
Klinik für Neurologie, Forschungszentrum Immuntherapie
Mainz
frauke.zipp@unimedizin-mainz.de

News

Wed, 22/11/2023
Hybrid seminar on ‘The origins and consequences of multiple slerosis’
Munich. Prof. Lars Fugger from the Nuffield Department of Clinical Neurosciences at the University of Oxford will give a hybrid seminar on ‘The origins and consequences of multiple slerosis’ in the large auditorium at the TranslaTUM in MUNICH. The talk is organized by the TRR 355 and will be streamed via the TRR 355 seminar […]...more
Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
New Date: Neurology Webinar – How much gut needs the brain
Muenster. In January 2024, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, January 24, 2024 Place: Online at zoom. […]...more