Molecular dissection of autoimmune lesion induction and resolution in the central nervous system

B10

The formation and resolution of neuroinflammatory lesions is determined by the balance of lesion-inducing signals derived from infiltrating auto-reactive T cells and lesion-resolving signals at least in part derived from CNS resident cells. Here we now want to use CRISPR gene editing screens to characterize the molecular architecture underlying these critical neuro-immune interactions and validate the disease relevance of emerging communication pathways in deeply phenotyped bi-osamples from MS patients. In detail, we will tackle these questions:

    1. What are the molecular regulators that enable or limit CNS-entry of encephalitogenic T cells and how do they work?
    2. Which molecules contribute to the T-cell-instructed phagocyte recruitment and polarization?
    3. What kind of molecules contribute to the CNS-instructed phagocyte re-polarization?

      Locatelli et al., Nat Neurosci. 2018

 

Principal Investigators:

Univ.-Prof. Dr. med. Martin Kerschensteiner
Institut für Klinische Neuroimmunologie
München
martin.kerschensteiner@med.uni-muenchen.de

Priv.-Doz. Dr. rer. nat. Naoto Kawakami
Institut für Klinische Neuroimmunologie
München
naoto.kawakami@med.uni-muenchen.de

News

Thu, 15/09/2022
Photo gallery: Inflammation & Imaging Symposium in the MIC building
Muenster. From September 12th to 14th scientists from Muenster University and their international guests discussed the latest developments in research on inflammation and the imaging of the immune system at the 2nd Inflammation & Imaging Symposium. The annual event is jointly organised by several research networks from Münster, among them the CRC/TRR 128 “Multiple Sclerosis”. […]...more
Tue, 28/06/2022
CRC Retreat in Münster
Muenster. After a long pause, more than 90 participants of the CRC joined in Muenster Factory Hotel to update on the latest developments. We heard the most recent on a selection of the CRC projects and there was also plenty of time for fruitful discussion and socializing in the evening....more
Mon, 23/05/2022
EU Research Council awards Lydia Sorokin Advanced Grant
Münster – The biochemist and Principal investigator of the CRC 128 Prof. Dr. Lydia Sorokin has received the coveted “Advanced Grant” awarded by the European Research Council (ERC). The funding of ca. 2.3 million euros enables the realisation of outstanding research projects. Lydia Sorokin heads the Institute for Physiological Chemistry and Pathobiochemistry at Muenster University. […]...more