Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
Neurology Webinar – How much gut needs the brain
Muenster. In December 2023, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, December 13, 5:15 p.m. Place: Online at […]...more
Thu, 02/02/2023
3rd Inflammation & Imaging Symposium in Münster, 11-13 September 2023
Application has opened! We cordially invite you to join this international conference and discuss the latest developments in research on inflammation and the imaging of the immune system with us. The symposium is organised by eight research networks from the University of Münster – CRU 342, CRC 1009, CRC 1450, CRC/TR 128, CRC/TR 332, InFlame, […]...more

Mon, 23/05/2022 | EU Research Council awards Lydia Sorokin Advanced Grant

Münster – The biochemist and Principal investigator of the CRC 128 Prof. Dr. Lydia Sorokin has received the coveted “Advanced Grant” awarded by the European Research Council (ERC). The funding of ca. 2.3 million euros enables the realisation of outstanding research projects.
Lydia Sorokin heads the Institute for Physiological Chemistry and Pathobiochemistry at Muenster University. She investigates the extracellular matrix (ECM) of blood vessels, especially those of the brain. These vessels are impermeable to cells, toxins, and pathogens and are part of the blood-brain barrier (BBB). One of Lydia Sorokin’s most important projects deals with multiple sclerosis and the question of how leukocytes penetrate the brain via the BBB in this disease, thereby causing disease symptoms. The focus is on a particular space discovered by the Sorokin team that surrounds the cerebral blood vessels and is formed by structures of the ECM. This is a favourite residence of leukocytes before they enter the brain in inflammatory brain diseases. The aim of the ERC grant-funded project is to investigate the molecular processes that are required to maintain the BBB, but allow immune cells to penetrate this barrier. To this end, Lydia Sorokin and her team want to reproduce the essential components of the BBB in vitro in three dimensions. Combined with studies on genetically modified mice, the researchers want to find out how the leukocytes manage to penetrate the brain in inflammatory diseases. The replication of the BBB in the laboratory will allow for testing of different substances in order to develop novel drugs against inflammation or tumours in the brain.
The “Advanced Grants” funding line is aimed at established scientists, who have produced outstanding scientific work over the past ten years.