Projects

Project area A focuses on the elucidation of innate and adaptive mechanisms related to the etiology, onset and course of chronic neuroinflammation.

While projects A1-A3 study principal processes of the immune response, projects A4-A6 mainly investigate the initiating (or perpetuating) adaptive immune factors in the disease, and A7-A9 focus on the balance of different adaptive immune responses. Important intracellular functions (A3) as well as antigen recognition (A4-A6) and differentiation or shaping of relevant pro-inflammatory or regulatory lymphocyte subpopulations (A7-A9) are in the center of these projects. Developing the human immune system, in particular the role of lymphocytes, in rodents (A9) will enable us to better achieve our goal of clinical translation.

To learn more about the individual projects, please visit the Project area A page.

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Project Area B addresses significant processes related to transmigration and infiltration of immune cells into the CNS as well as lesion development, lesion resolution and the impact for the overall functional outcome. These approaches often combine molecular and cellular mechanisms with innovative imaging tools, both in rodent experimental systems and in humans.

Projects B1-B3 investigate the routes of the immune cells and the involved processes at and beyond the blood brain barrier. From there project B4 goes on to the perivascular space and studies antigen-presenting cells (APC) and their capacity to shape the T cell response within the CNS. Project B5 and B6 study an inflammatory lesion and its impact on neuronal network and functional outcome. While project B5 examines this part of the pathology in patients with Multiple Sclerosis using a combination of imaging and advanced electrophysiology, project B6 investigates it in brain slices and rodent models. Projects B7 and B8 study processes of de- and remyelination, also analyzing underlying causes for demyelinated and remyelinated lesions in patients. Processes of neuronal injury as well as the regenerative capacity in the neuronal compartment are investigated in the projects B9 and B10.

To learn more about the individual projects, please visit the Project area B page.

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Project Area Z consists of a Clinical Translation Unit. The overall aim of this platform is to support various translational aspects of the CRC128. In particular, we pursue the following approaches:

  • Provide a platform for „proof-of-concept“ clinical studies (association with project A08)
  • Present a translational platform for support of single scientific projects in order to strengthen their translational aspects (examples are A01, A08, A09, B03, B07)
  • Provide a service platform in terms of infrastructure as well as biomaterial collection for use in individual scientific projects (examples are A08, A09, A10, B01, B08)

Schematic presentation of assays and methods provided within the CTU

To learn more about the individual projects, please visit the Project area Z page.

News

Tue, 05/06/2018
21st Meeting on T-Cells, Subsets and Functions
Marburg. SFB-PI Prof. Dr. Tobias Bopp & Prof. Dr. Magdalena Huber are chairing this year’s “21st Meeting on T-Cells, Subsets and Functions“ in Marburg. The two-day conference covers all recent aspects of T cell subsets, including Th1, Zh2, Th17, CD8 NKT and regulatory T cells When?: Thursday, June 21, 12.00 – 8.00 PM and Wednesday, […]...more
Fri, 25/05/2018
SFB/CRC-TR 128 retreat in Munich
Munich. The CRC-TR 128 “Multiple Sclerosis” cordially invites all its members – principal investigators as well as associated scientists and young investigators – to meet for a general scientific update, discussion and exchange at this year’s retreat. In addition to the PI meeting there will be a one-day conference especially for young investigators. When?: Thursday […]...more
Tue, 10/04/2018
Lecture: Environmental influence on the immune system
Mainz. The Research Center for Immunotherapy (FZI) and CRC 1292 are happy to welcome SFB 128 PI Prof. Karin Loser, MD, as a guest lecturer at their immunological seminar. Prof. Loser will talk about “Control of Immune responses by the environment”. When?: Thursday, April 26, 5:00 PM Where? University Medical Center Mainz, building 708, seminar […]...more