Project Area A

Innate and adaptive immune mechanisms outside of the CNS

 

A01

The impact of nutrition and the gut microbiome in the pathogenesis of multiple sclerosis and its therapeutic implications

PD Dr. Gurumoorthy Krishnamoorthy
MPI für Biochemie
Martinsried

Prof. Dr. Aiden Haghikia
Klinikum der Ruhr-Universität
Bochum

Prof. Dr. Ralf Gold
Klinikum der Ruhr-Universität
Bochum

 

A03

G-protein-coupled receptor signaling in immune cells and endothelial cells: implications for neuroinflammation

Prof. Dr. Nina Wettschureck
Institut für Molekulare Medizin / MPI für Herz- und Lungenforschung
Frankfurt / Bad Nauheim

Prof. Dr. Ari Waisman
Institut für Molekulare Medizin
Mainz

 

A04

Tissue specific regulation of ion channels and immunological responses in multiple sclerosis

Prof. Dr. Bernhard Hemmer
Klinik für Neurologie
TU München

Dr. Klaus Lehmann-Horn
Klinik für Neurologie
TU München

 

A05

Synoptic analysis of adaptive immune reactions in very early multiple sclerosis: Repertoires and target antigens of B and T cells

PD Dr. Klaus Dornmair
Institut für Klinische Neuroimmunologie
LMU München

Prof. Dr. Reinhard Hohlfeld
Institut für Klinische Neuroimmunologie
LMU München

 

A07

A novel IL-6 signaling modality in the direct interaction of immune cells

Prof. Dr. Ari Waisman
Institut für Molekulare Medizin
Mainz

Prof. Dr. Thomas Korn
Neurologische Klinik
TU München

 

A08

Impact of dietary factors on the gut-CNS-axis – implications for CNS autoimmunity

Prof. Dr. Luisa Klotz
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster

Prof. Dr. Dr. Detlef Schuppan
Institut für Translationale Immunologie
Mainz

 

A09

Analysis and therapeutic modification of innate immune regulatory networks controlling T cell responses in multiple sclerosis

Prof. Prof. h.c. Dr. Heinz Wiendl
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster

Dr. Catharina Groß
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster

 

A10

Skin-sensing of environmental factors and ther impact on the development of multiple sclerosis

Prof. Prof. h.c. Dr. Heinz Wiendl
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster

Prof. Dr. Karin Loser
Klinik für Dermatologie
Münster

News

Thu, 29/08/2019
Symposium: Multiple Sclerosis: balancing effector and regenerative pathways
The International Symposium of the Collaborative Research Centre 128 “Multiple Sclerosis” will take place from 08:30 on Monday 16th until 14:00 on Tuesday 17th September, 2019 at the University Medical Center in Mainz and will end with a general assembly for SFB members. A full program for the meeting can be found here....more
Mon, 03/06/2019
Publication: Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.
Muenster. For the first time scientists from the University of Münster could show that multiple sclerosis (MS) alters the energy metabolism of T cells during acute phases of disease exacerbation. Therapeutic interventions targeting the metabolism of activated T cells display new potential avenues for treatment of patients with MS affecting around 250,000 people in Germany. The […]...more
Mon, 29/04/2019
Publication: Calcium influx through plasma-membrane nanoruptures drives axon degeneration in a model of multiple sclerosis.
Munich.  Here SFB researchers from Munich use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. Calcium can enter the axon through nanoscale ruptures of the axonal plasma membrane that are induced in inflammatory lesions. Neuron doi: 10.1016/ j.neuron.2018.12.023...more