Project Area B

Transmigration, CNS damage and repair

 

B01

Immuneregulation at the CNS barriers and in the CNS: role of immune cell trafficking

Prof. Dr. Nicholas Schwab
Klinik für Allgemeine Neurologie
Münster

Prof. Dr. Alexander Zarbock
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerzmedizin
Münster

 

B03

Molecular mechanisms and in vivo tracking of leukocyte penetration of the blood–brain barrier (BBB) in autoimmune CNS inflammation

Prof. Lydia Sorokin
Institut für Physiologische Chemie und Pathobiochemie
Münster

Prof. Michael Schäfers
Europäisches Institut für Molekulare Bildgebung
Münster

 

B04

T helper cell balance in chronic neuroinflammation – influence by antigen-presenting cells

Prof. Dr. Frauke Zipp
Klinik für Neurologie
Mainz

Prof. Dr. Tobias Bopp
Insitut für Immunologie
Mainz

 

B05

Identifying distinct functional and structural connectivity patterns of network compensation and repair in early autoimmune neuroinflammation

Prof. Dr. Sergiu Groppa
Klinik für Neurologie
Mainz

Prof. Dr. Frauke Zipp
Klinik für Neurologie
Mainz

Prof. Dr. Dr. Sven Meuth
Klinik für Allgemeine Neurologie / Institut für Translationale Neurologie
Münster

 

B06

K+ channels of the K2P and Kv7 families contribute to functional and structural impairment of network activity in animal models of multiple sclerosis

Prof. Dr. Dr. Sven Meuth
Klinik für Neurologie / Institut für Translationale Neurologie
Münster

Prof. Dr. Thomas Budde
Institut für Physiologie I
Münster

Prof. Dr. Hans-Christian Pape
Institut für Physiologie I
Münster

 

B07

Oligodendrocyte progenitor cells in de- and remyelination: release of differentiation brakes in mouse and human cells

Prof. Dr. Jacqueline Trotter
Abteilung für Molekulare Zellbiologie
Mainz

Prof. Dr. Tanja Kuhlmann
Institut für Neuropathologie
Münster

 

B08

Humoral Immunity in Multiple Sclerosis

Prof. Dr. Edgar Meinl
Institut für Klinische Neuroimmunologie
LMU München

Prof. Dr. Reinhard Hohlfeld
Institut für Klinische Neuroimmunologie
LMU München

 

B09

Mechanisms underlying immune-mediated neuronal damage: neuronal hyperexcitability as starting point for neurodegeneration in Multiple Sclerosis

Prof. Dr. Albrecht Stroh
Institut für Mikroskopische Anatomie und Neurobiologie
Mainz

Prof. Dr. Frauke Zipp
Klinik für Neurologie
Mainz

 

B10

Dynamics, local specification and adaptive regulation of phagocyte phenotypes in the course of neuroinflammation

Prof. Dr. Martin Kerschensteiner
Institut für Klinische Neuroimmunologie
LMU München

PD Dr. Naoto Kawakami
Institut für Klinische Neuroimmunologie
LMU München

 

B11

A role for menningeal lymphatic vessels in the regulation of CNS inflammation

Prof. Dr. Jonathan Kipnis
Gutenberg-Forschungskolleg
Mainz

 

B12

Role of two pore domain potassium channel signalling in CNS immunity and inflammatory neuronal injury

Prof. Dr. Stefan Bittner
Klinik für Neurologie
Mainz

 

B13

Mechanisms of myelin clearance and repair in demyelinating diseases

Prof. Dr. Mikael Simons
Institut für Neuronale Zellbiologie
TU München

Prof. Dr. Martin Kerschensteiner
Institut für Klinische Neuroimmunologie
LMU München

News

Tue, 17/10/2017
Three new CRC associates
Muenster / Mainz / Munich. The CRC is proud to welcome three scientists as new associates: Muthuraman Muthuraman (Mainz), Anneli Peters (LMU) and Gerd Meyer zu Hörste (Münster). All three are reputable neuroimmunologists, who add their in-depth knowledge of techniques and concepts to the existing team. Dr. Muthuraman Muthuraman is head of the scientific working group […]...more
Tue, 12/09/2017
Genetically altered mice provide initial evidence that human gut bacteria can trigger multiple sclerosis
Munich. (LMU)  Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system. There are many indications that MS is an autoimmune disease in which immune cells “accidentally” attack the brain and spinal cord. However, as with other autoimmune diseases, the actual triggers of the autoimmune reaction are still unknown. A new […]...more
Sun, 10/09/2017
SFB researcher acquired Hertie foundation funding
Munich. SFB CRC 128 researcher Dr. Klaus Lehmann-Horn, Department of Neurology, has acquired 396.000€ of funding as part of the framework „MyLab“, which is sponsored by the Hertie foundation. The duration of the project „Antigen-driven affinity maturation of B lymphocytes in meningeal ectopic lymphoid tissue in a model of Multiple Sclerosis“ will be 5 years, […]...more