Project Area B

Transmigration, CNS damage and repair

 

B01

Immuneregulation at the CNS barriers and in the CNS: role of immune cell trafficking

Prof. Dr. Nicholas Schwab
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster

Prof. Dr. Alexander Zarbock
Klinik für Anästhesiologie, operative Intensivmedizin und Schmerzmedizin
Münster

 

B03

Molecular mechanisms and in vivo tracking of leukocyte penetration of the blood–brain barrier (BBB) in autoimmune CNS inflammation

Prof. Lydia Sorokin
Institut für Physiologische Chemie und Pathobiochemie
Münster

Prof. Michael Schäfers
Europäisches Institut für Molekulare Bildgebung
Münster

 

B04

T helper cell balance in chronic neuroinflammation – influence by antigen-presenting cells

Prof. Dr. Frauke Zipp
Klinik für Neurologie
Mainz

Prof. Dr. Tobias Bopp
Insitut für Immunologie
Mainz

 

B05

Identifying distinct functional and structural connectivity patterns of network compensation and repair in early autoimmune neuroinflammation

Prof. Dr. Sergiu Groppa
Klinik für Neurologie
Mainz

Prof. Dr. Frauke Zipp
Klinik für Neurologie
Mainz

Prof. Dr. Dr. Sven Meuth
Klinik für Allgemeine Neurologie mit Institut für Translationale Neurologie
Münster

 

B06

K+ channels of the K2P and Kv7 families contribute to functional and structural impairment of network activity in animal models of multiple sclerosis

Prof. Dr. Dr. Sven Meuth
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster

Prof. Dr. Thomas Budde
Institut für Physiologie I
Münster

Prof. Dr. Hans-Christian Pape
Institut für Physiologie I
Münster

 

B07

Oligodendrocyte progenitor cells in de- and remyelination: release of differentiation brakes in mouse and human cells

Prof. Dr. Jacqueline Trotter
Abteilung für Molekulare Zellbiologie
Mainz

Prof. Dr. Tanja Kuhlmann
Institut für Neuropathologie
Münster

 

B08

Humoral Immunity in Multiple Sclerosis

Prof. Dr. Edgar Meinl
Institut für Klinische Neuroimmunologie
LMU München

Prof. Dr. Reinhard Hohlfeld
Institut für Klinische Neuroimmunologie
LMU München

 

B09

Mechanisms underlying immune-mediated neuronal damage: neuronal hyperexcitability as starting point for neurodegeneration in Multiple Sclerosis

Prof. Dr. Albrecht Stroh
Institut für Mikroskopische Anatomie und Neurobiologie
Mainz

Prof. Dr. Frauke Zipp
Klinik für Neurologie
Mainz

 

B10

Dynamics, local specification and adaptive regulation of phagocyte phenotypes in the course of neuroinflammation

Prof. Dr. Martin Kerschensteiner
Institut für Klinische Neuroimmunologie
LMU München

PD Dr. Naoto Kawakami
Institut für Klinische Neuroimmunologie
LMU München

 

B11

A role for menningeal lymphatic vessels in the regulation of CNS inflammation

Prof. Dr. Jonathan Kipnis
Gutenberg-Forschungskolleg
Mainz

 

B12

Role of two pore domain potassium channel signalling in CNS immunity and inflammatory neuronal injury

Prof. Dr. Stefan Bittner
Klinik für Neurologie
Mainz

 

B13

Mechanisms of myelin clearance and repair in demyelinating diseases

Prof. Dr. Mikael Simons
Institut für Neuronale Zellbiologie
TU München

Prof. Dr. Martin Kerschensteiner
Institut für Klinische Neuroimmunologie
LMU München

News

Thu, 28/01/2021
BioNTech Publishes Data on Novel mRNA Vaccine Approach to Treat Autoimmune Diseases in Science
BioNTech SE (Nasdaq: BNTX, “BioNTech” or “the Company”) announced the publication of preclinical data on its novel mRNA vaccine approach against autoimmune diseases in the peer-reviewed journal Science. The publication titled “A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis” co-authored by SFB principal investigator Ari Waisman summarizes the findings on the disease-suppressing effects […]...more
Wed, 20/01/2021
A new study on neurological manifestations of severe COVID-19 reveals nervous system immune deficiency
Patients suffering from COVID-19 can develop concomitant and long-term symptoms in their nervous system. The most common symptom in this context is the loss of the sense of smell and taste, while more severe symptoms such as stroke, cerebral seizures, or meningitis are possible. A team of scientists from the medical faculties at the Universities […]...more
Fri, 15/01/2021
Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity
It has long been acknowledged that multiple sclerosis disease risk is associated with reduced sun-exposure, and subsequent low vitamin D levels. The study by Ostkamp et al. now assessed the relationship between measures of sun exposure and MS severity. For this, the researchers analyzed data of around 2,000 patients from the German NationMS- and the […]...more