News

Mon, 03/06/2019
Publication: Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects.
Muenster. For the first time scientists from the University of Münster could show that multiple sclerosis (MS) alters the energy metabolism of T cells during acute phases of disease exacerbation. Therapeutic interventions targeting the metabolism of activated T cells display new potential avenues for treatment of patients with MS affecting around 250,000 people in Germany. The […]...more
Mon, 29/04/2019
Publication: Calcium influx through plasma-membrane nanoruptures drives axon degeneration in a model of multiple sclerosis.
Munich.  Here SFB researchers from Munich use in vivo calcium imaging in a multiple sclerosis model to show that cytoplasmic calcium levels determine the choice between axon loss and survival. Calcium can enter the axon through nanoscale ruptures of the axonal plasma membrane that are induced in inflammatory lesions. Neuron doi: 10.1016/ j.neuron.2018.12.023...more
Tue, 04/12/2018
SFB 128 International Symposium
SFB 128. We are happy to announce the international Symposium of the Collaborative Research Centre 128 “Multiple Sclerosis” taking place from Sunday, September 15th, till Tuesday, September 17th, 2019 in the Rhine Main region. Full details of the event will follow....more


Fri, 04/03/2016 | Two young researchers from CRC TR128 awarded Helmut Bauer Prize 2015

Sarah Laurent und Franziska Thaler, scientists working on the B08 project of the CRC TR128, have been awarded the Helmut Bauer Prize 2015 for young researchers for their work on the survival, regulation and activation of B cells in multiple sclerosis (see publications below). More information on this prize can be found in this press release (in German).

Laurent et al. γ-Secretase directly sheds the survival receptor BCMA from plasma cells Nat Commun 2015 6:7333

Hoffmann et al. The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity J Immunol 2015 194(2):542-52