Analysis and therapeutic modifications of innate immune regulatory networks in controlling T-cell activation in MS

A09

Innate immune-regulatory networks are crucial for controlling T-cell activation in MS. By combining access to unique samples with cutting-edge technologies, we aim to investigate immune-regulatory networks of peripheral (blood, lymph node) and CNS associated (cerebrospinal fluid) immune compartments to:

    1. understand alterations of these networks during disease initiation and progression in MS
    2. identifying parameters discriminating MS from other neuroinflammatory autoimmune diseases;
    3. exploring the impact of immune-modulating therapies on these networks; and
    4. generating an MS-specific immunological roadmap in distinct compartments as a path for diagnostic, prognostic, and therapeutic signatures.

 

 

 

 

 

 

 

 

Principal Investigators:

Univ.-Prof. Prof. h.c. Dr. med. Heinz Wiendl
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
heinz.wiendl@ukmuenster.de

Dr. rer. nat. Catharina Groß
Klinik für Neurologie mit Institut für Translationale Neurologie
Münster
catharina.gross@ukmuenster.de

News

Wed, 19/01/2022
One drug – different effects: Metabolism of immune cells influences mode of action and could be an indicator for side effects
Muenster – One person can eat large amounts of pasta and still be a small dress size while another looks at a piece of chocolate and puts on weight: metabolism varies between individuals – and this goes beyond a subjective feeling. What is apparent in the overall organism also applies to each cell: the metabolism […]...more
Tue, 14/12/2021
Save the date: 2nd Inflammation & Imaging Symposium
Münster. Save the date: 12-14 September 2022! We cordially invite you to join this international symposium, jointly organized by the research networks CRC 1450, CRC 1009, CRC 1348, CRU 342, CRC/TR 128 and the Cells in Motion Interfaculty Centre at the University of Münster. At the same time, we will officially open the new research […]...more
Mon, 09/08/2021
Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity
A close interaction between gut immune responses and distant organ-specific autoimmunity including the CNS in multiple sclerosis has been established in recent years. This so-called gut-CNS axis can be shaped by dietary factors, either directly or via indirect modulation of the gut microbiome and its metabolites. Here, SFB 128 PI Luisa Klotz and colleagues report […]...more