Topological patterns of damage and compensation in chronic neuroinflammation

B05

Although research has made significant progress, there are still mechanistic factors that markedly influence disease progression and compensation reserve, making an accurate prognosis of sub-group and individual disease courses in MS extremely challenging. We aim at elaborating the framework for the automatic stratification of disease courses and therapeutic responses. Using advanced magnetic resonance imaging (MRI) together with brain networks phenotyping and immune response analyses, we aim to early recognize patients at high risk for disease progression (i.e. evolving functional impairment) or with insufficient therapeutic responses to immunomodulation:

    1. Can the acute individual network response help to predict future relapses and long-term disease trajectories?
    2. What is the difference in chronic network responses between patients with continuous functional worsening compared to clinically stable patients?
    3. How do the predictive differences of grey matter (GM) and white matter (WM) lesion localization impact on network dynamics and disease progression?
    4. What is the role of cortical lesions and their corresponding dynamics (enlarging, smoldering lesions) for WM and GM network reorganization and evolving functional impairment?
    5. Can peripheral immunological markers be linked to data from MRI network analysis to improve the understanding of the pathomechanisms underlying network reorganization in MS?

 

 

 

 

 

 

 

 

 

 

 

Principal Investigators:

Prof. Dr. med. Sergiu Groppa
Klinik für Neurologie
Mainz
segroppa@uni-mainz.de

Prof. Dr.-Ing. Muthuraman Muthuraman
Klinik für Neurologie
Mainz
mmuthura@uni-mainz.de

Univ.-Prof. Dr. med. Dr. rer. nat. Dr. h.c. Sven G. Meuth
Klinik für Neurologie
Düsseldorf
sven.meuth@med.uni-duesseldorf.de

News

Wed, 22/11/2023
Hybrid seminar on ‘The origins and consequences of multiple slerosis’
Munich. Prof. Lars Fugger from the Nuffield Department of Clinical Neurosciences at the University of Oxford will give a hybrid seminar on ‘The origins and consequences of multiple slerosis’ in the large auditorium at the TranslaTUM in MUNICH. The talk is organized by the TRR 355 and will be streamed via the TRR 355 seminar […]...more
Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
New Date: Neurology Webinar – How much gut needs the brain
Muenster. In January 2024, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, January 24, 2024 Place: Online at zoom. […]...more