The role of thr kallikrein-kinin system to functional and structural impairment if network activity in multiple sclerosis


Neuronal connectivity and network functions are important for the understanding of multiple sclerosis and its animal models – particularly ion channels play a key role. We established a combination of electrophysical and behavioural techniques to characterize neuronal properties in multiple sclerosis (MS) disease models in vitro and in vivo. We identified a transient period of increased excitability in the thalamocortical neuronal network in the course of inflammatory and demyelinating events. Preliminary data point to specific K+ channels, cytokines and components of the kallikrein-kinin system (KKS) as modulators of neuronal hyperexcitability in animal models of MS. In this funding period, we aim to investigate how the KKS influences MS pathophysiology and to identify the underlying cellular and neuronal network effects. In addition, we aim to establish components of the KKS as possible human biomarkers for different forms of MS and effector channels of KKS signaling as new potential therapeutic targets. Our central questions are::

    1. Can kininogen and KLKs influence MS pathophysiology and what are their cellular and neuronal network effect?
    2. Are serum kininogen levels influenced by neuronal network functions?
    3. Kininogen depositions are found in active MS lesions in close contact to neurons. Are these depositions influencing their function and thus modify the course of disease?













Principal Investigators:

Prof. Dr. rer. nat. Thomas Budde
Institut für Physiologie I

Dr. med. Kerstin Göbel
Klinik für Neurologie mit Institut für Translationale Neurologie

Univ.-Prof. Dr. med. Dr. rer. nat. Dr. h.c. Sven Meuth
Klinik für Neurologie


Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
Neurology Webinar – How much gut needs the brain
Muenster. In December 2023, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, December 13, 5:15 p.m. Place: Online at […]...more
Thu, 02/02/2023
3rd Inflammation & Imaging Symposium in Münster, 11-13 September 2023
Application has opened! We cordially invite you to join this international conference and discuss the latest developments in research on inflammation and the imaging of the immune system with us. The symposium is organised by eight research networks from the University of Münster – CRU 342, CRC 1009, CRC 1450, CRC/TR 128, CRC/TR 332, InFlame, […]...more