The role of thr kallikrein-kinin system to functional and structural impairment if network activity in multiple sclerosis


Neuronal connectivity and network functions are important for the understanding of multiple sclerosis and its animal models – particularly ion channels play a key role. We established a combination of electrophysical and behavioural techniques to characterize neuronal properties in multiple sclerosis (MS) disease models in vitro and in vivo. We identified a transient period of increased excitability in the thalamocortical neuronal network in the course of inflammatory and demyelinating events. Preliminary data point to specific K+ channels, cytokines and components of the kallikrein-kinin system (KKS) as modulators of neuronal hyperexcitability in animal models of MS. In this funding period, we aim to investigate how the KKS influences MS pathophysiology and to identify the underlying cellular and neuronal network effects. In addition, we aim to establish components of the KKS as possible human biomarkers for different forms of MS and effector channels of KKS signaling as new potential therapeutic targets. Our central questions are::

    1. Can kininogen and KLKs influence MS pathophysiology and what are their cellular and neuronal network effect?
    2. Are serum kininogen levels influenced by neuronal network functions?
    3. Kininogen depositions are found in active MS lesions in close contact to neurons. Are these depositions influencing their function and thus modify the course of disease?













Principal Investigators:

Prof. Dr. rer. nat. Thomas Budde
Institut für Physiologie I

Dr. med. Kerstin Göbel
Klinik für Neurologie mit Institut für Translationale Neurologie

Univ.-Prof. Dr. med. Dr. rer. nat. Dr. h.c. Sven Meuth
Klinik für Neurologie


Tue, 14/12/2021
Save the date: 2nd Inflammation & Imaging Symposium
Münster. Save the date: 12-14 September 2022! We cordially invite you to join this international symposium, jointly organized by the research networks CRC 1450, CRC 1009, CRC 1348, CRU 342, CRC/TR 128 and the Cells in Motion Interfaculty Centre at the University of Münster. At the same time, we will officially open the new research […]...more
Mon, 09/08/2021
Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity
A close interaction between gut immune responses and distant organ-specific autoimmunity including the CNS in multiple sclerosis has been established in recent years. This so-called gut-CNS axis can be shaped by dietary factors, either directly or via indirect modulation of the gut microbiome and its metabolites. Here, SFB 128 PI Luisa Klotz and colleagues report […]...more
Thu, 28/01/2021
BioNTech Publishes Data on Novel mRNA Vaccine Approach to Treat Autoimmune Diseases in Science
BioNTech SE (Nasdaq: BNTX, “BioNTech” or “the Company”) announced the publication of preclinical data on its novel mRNA vaccine approach against autoimmune diseases in the peer-reviewed journal Science. The publication titled “A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis” co-authored by SFB principal investigator Ari Waisman summarizes the findings on the disease-suppressing effects […]...more