Rebalancing cortical neuronal hyperactivity as a new treatment strategy in neuroinflammation

B09

In the previous funding period we discovered a maladaptive cortical network dysregulation linked with anxiety behavior as a pathological mechanism in murine neuroinflammation contributing to initiation of neurodegeneration. We now aim at (1) dissecting the causal relation between brainstem pathology and cortical maladaptive hyperactivity, (2) unravelling the relation of local network dysregulation to brain-wide networks, and (3) pharmacologically modulating cortical hyperexcitability and translating our findings to MS patients. These research questions will be investigated:

    1. Does the modulation of AMPA receptors have an effect in neuroinflammatory disorders?
    2. Does the reversal of anxiety symptoms prevent neurodegeneration?
    3. What’s the relation between local nework dysregulation in relapsing-remitting MS with brain-wide networks?
    4. Is there a causal relation between brainstem pathology and cortical maladaptive hyperactivity?

 

 

 

 

 

Principal Investigators:

Dr. med. Erik Ellwardt
Klinik für Neurologie
Mainz
erik.ellwardt@unimedizin-mainz.de

Prof. Dr. rer. nat. Albrecht Stroh
Institut für Mikroskopische Anatomie und Neurobiologie
Mainz
albrecht.stroh@unimedizin-mainz.de

News

Tue, 28/06/2022
CRC Retreat in Münster
Muenster. After a long pause, more than 90 participants of the CRC joined in Muenster Factory Hotel to update on the latest developments. We heard the most recent on a selection of the CRC projects and there was also plenty of time for fruitful discussion and socializing in the evening....more
Mon, 23/05/2022
EU Research Council awards Lydia Sorokin Advanced Grant
Münster – The biochemist and Principal investigator of the CRC 128 Prof. Dr. Lydia Sorokin has received the coveted “Advanced Grant” awarded by the European Research Council (ERC). The funding of ca. 2.3 million euros enables the realisation of outstanding research projects. Lydia Sorokin heads the Institute for Physiological Chemistry and Pathobiochemistry at Muenster University. […]...more
Wed, 19/01/2022
One drug – different effects: Metabolism of immune cells influences mode of action and could be an indicator for side effects
Muenster – One person can eat large amounts of pasta and still be a small dress size while another looks at a piece of chocolate and puts on weight: metabolism varies between individuals – and this goes beyond a subjective feeling. What is apparent in the overall organism also applies to each cell: the metabolism […]...more