Molecular dissection of autoimmune lesion induction and resolution in the central nervous system

B10

The formation and resolution of neuroinflammatory lesions is determined by the balance of lesion-inducing signals derived from infiltrating auto-reactive T cells and lesion-resolving signals at least in part derived from CNS resident cells. Here we now want to use CRISPR gene editing screens to characterize the molecular architecture underlying these critical neuro-immune interactions and validate the disease relevance of emerging communication pathways in deeply phenotyped bi-osamples from MS patients. In detail, we will tackle these questions:

    1. What are the molecular regulators that enable or limit CNS-entry of encephalitogenic T cells and how do they work?
    2. Which molecules contribute to the T-cell-instructed phagocyte recruitment and polarization?
    3. What kind of molecules contribute to the CNS-instructed phagocyte re-polarization?

      Locatelli et al., Nat Neurosci. 2018

 

Principal Investigators:

Univ.-Prof. Dr. med. Martin Kerschensteiner
Institut für Klinische Neuroimmunologie
München
martin.kerschensteiner@med.uni-muenchen.de

Priv.-Doz. Dr. rer. nat. Naoto Kawakami
Institut für Klinische Neuroimmunologie
München
naoto.kawakami@med.uni-muenchen.de

News

Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
Neurology Webinar – How much gut needs the brain
Muenster. In December 2023, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, December 13, 5:15 p.m. Place: Online at […]...more
Thu, 02/02/2023
3rd Inflammation & Imaging Symposium in Münster, 11-13 September 2023
Application has opened! We cordially invite you to join this international conference and discuss the latest developments in research on inflammation and the imaging of the immune system with us. The symposium is organised by eight research networks from the University of Münster – CRU 342, CRC 1009, CRC 1450, CRC/TR 128, CRC/TR 332, InFlame, […]...more