Welcome

Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl
Spokesperson

Frauke Zipp
Co-Spokesperson

News

Tue, 12/09/2017
Genetically altered mice provide initial evidence that human gut bacteria can trigger multiple sclerosis
Munich. (LMU)  Multiple sclerosis (MS) is the most common inflammatory disease of the central nervous system. There are many indications that MS is an autoimmune disease in which immune cells “accidentally” attack the brain and spinal cord. However, as with other autoimmune diseases, the actual triggers of the autoimmune reaction are still unknown. A new […]...more
Sun, 10/09/2017
SFB researcher acquired Hertie foundation funding
Munich. SFB CRC 128 researcher Dr. Klaus Lehmann-Horn, Department of Neurology, has acquired 396.000€ of funding as part of the framework „MyLab“, which is sponsored by the Hertie foundation. The duration of the project „Antigen-driven affinity maturation of B lymphocytes in meningeal ectopic lymphoid tissue in a model of Multiple Sclerosis“ will be 5 years, […]...more
Mon, 14/08/2017
Lecture: Latest research on HIV-1
Mainz. HIV-1, the major causative agent of AIDS, has infected more than 60 million people and caused around 20 million deaths worldwide (WHO report 2009). Prof. Frank Kirchhoff, director of the Institute of Molecular Virology, Ulm, is one of Germany’s most recognized scientists investigating HIV-1. Kirchhoff has been honoured by numerous awards – among them […]...more