Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Prof. Frauke Zipp Spokesperson Prof. Heinz Wiendl Co-spokesperson

Frauke Zipp


Heinz Wiendl



Mon, 19/09/2016
19-20 September 2016: EMBL/DFG Women in Science Network Conference
On the 19-20 September 2016, the EMBL/DFG Women in Science Network Conference “From Genes, Cells and the Immune System towards Therapies” will take place in Heidelberg and will be supported by the CRC-TR-128. For more information, you can download the flyer....more
Fri, 04/03/2016
Stipend for International Cooperation with Turkey (Project B08)
Dr. Atay Vural has been awarded a stipend by the Alexander von Humboldt Foundation to spend time in the group of Prof. Edgar Meinl to conduct research into MOG-Ak, which is part of the work done in the CRC-TR128 B08 project. After Dr. Vural’s stay in Prof. Meinl’s group, he will return to his home […]...more
Fri, 04/03/2016
Two young researchers from CRC TR128 awarded Helmut Bauer Prize 2015
Sarah Laurent und Franziska Thaler, scientists working on the B08 project of the CRC TR128, have been awarded the Helmut Bauer Prize 2015 for young researchers for their work on the survival, regulation and activation of B cells in multiple sclerosis (see publications below). More information on this prize can be found in this press release (in […]...more