Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl

Frauke Zipp


Wed, 17/05/2017
Swedish Data on Rituximab – Presentation by Fredrik Piehl
Munich. Sweden is the only country where the MS treatment Rituximab is frequently used even if it has not been formally approved. The neuroimmunologist mainly responsible for this fact is MS researcher Fredrik Piehl from Karolinska Institutet in Stockholm/Sweden. His research group provided observational data on Rituximab therapy and will now start a large clinical […]...more
Wed, 17/05/2017
Hematopoietic Stem Cell Niche and Cell Signaling
Mainz. Borhane Guezguez (Mainz/Frankfurt/Heidelberg) has recently become head of a scientific working group at UCI. He will present his work in a lecture on “Hematopoietic Stem Cell Niche and Cell Signaling: From Biological Aspects To Therapeutic Perspectives” Time: Wednesday, 17th of May,5:15pm Place: Building 708, SR2, University Medical Center, Langenbeckstr. 1, Mainz...more
Wed, 17/05/2017
Lecture: MS: Can we develop therapies?
Muenster. The Department of Neurology is happy to announce that Dr. Susan Goelz will give a lecture as part of the Neurological Seminar. Time: Wednesday, 17th of May, 6:15pm Place: Large conference room, Level 05 West in the central clinics building, Albert-Scweitzer-Campus 1, Building A 1, 48149 Muenster Title of her talk: „Putative pathways leading […]...more