Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl

Frauke Zipp


Mon, 05/11/2018
Lecture “Foxp3+ Treg cells in autoimmune CNS inflammation”
Münster. SFB128-PI Thomas Korn is invited to present his work at the lecture series Pioneers in Cell Dynamics and Imaging, featured by the DFG-funded Cluster of Excellence Cells in Motion. There he will elaborate on the topic “Foxp3+ Treg cells in autoimmune CNS inflammation”. Venue: lecture hall of the Institute of Physiological Chemistry and Pathobiochemistry, […]...more
Mon, 05/11/2018
Winter Symposium on Neuroinflammation
Mainz. The Department of Neurology at Mainz University Medical Centre cordially invites scientists to attend its Winter Symposium. The one-day event on neuroinflammation will present the most interesting highlights in the field as well as new insights into pathogenesis, diagnostics and therapy management of neuroimmunological disorders. The organizers Prof. Frauke Zipp and Prof. Stefan Bittner […]...more
Fri, 26/10/2018
Featured publication: Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk
In a large multi-cohort study, performed by the International Multiple Sclerosis Genetics Consortium (IMSGC) and published in Cell Magazine, unexplained heritability for multiple sclerosis (MS) is detected in low-frequency coding variants that are missed by genome-wide association study (GWAS) analyses, further underscoring the role of immune genes in MS pathology. The IMSGC was formed in […]...more