Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl

Frauke Zipp


Fri, 02/12/2016
Lost in Translation?!
Münster – Prof. Mathias Bähr, Director of the Department of Neurology, University of Göttingen, is an expert on cellular and molecular mechanisms of neuronal dysfunction and neuronal cell death in animal models of the respective disorders; his ultimate goal is to detect new targets for therapeutic neuroprotective intervention. But how can research in this field […]...more
Fri, 02/12/2016
High ranking guests at the FTN and FZI lecture series in Mainz
Mainz – Within the FTN and FZI lecture series Mainz welcomes high-ranking experts in the field of neuroimmunology who will present their research in the upcoming months: Prof. Alexandre Prat, MD PhD, Head of Neuroscience, CHUM, Professor of Neuroscience, Université de Montréal – “Vascular Determinants of Lesion Formation in Multiple Sclerosis” Place: Seminar Room 2, […]...more
Fri, 02/12/2016
Idiopathic inflammatory Myopathies – Scientific and clinical update
Münster – The Department of Neurology Muenster welcomes one of its scientists for a lecture on 14th December: Tobias Ruck, MD from the working group of Profs. Heinz Wiendl and Sven Meuth will give a state of the art report on research and therapy of idiopathic inflammatory myopathies (lecture in German) Place: Conference Room 05.603, […]...more