Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl

Frauke Zipp


Fri, 16/03/2018
Lecture on Cell Interactions at the Blood-Brain-barrier
Muenster. The DFG-funded Comprehensive Research Centre “Breaking Barriers” cordially invites everyone interested in neuroimmunology to its upcoming Jour-Fixe Meeting where Luisa Klotz and Heinz Wiendl – both acting as PIs in the DFG-funded CRC “Multiple Sclerosis” (128) as well as “Breaking Barriers” (1009) – will hold a lecture on “Immune Cell Interactions with Endothelial Cells […]...more
Fri, 16/03/2018
Exposition on scientific co-operation with Iran
Muenster. From March 21-23 the exposition „A History of Scientific co-operation between Germany and Iran“ will be shown at the Medical Faculty Muenster. Instigated by a cooperation between the University of Muenster and Masshad Medical School, the national ministries of education in both countries signed a common declaration with the aim of fostering cooperation and […]...more
Fri, 16/02/2018
Introduction into Histopathology of MS
Muenster, The CRC-128 „Multiple Sclerosis“ offers an histopathology course for its members. The two-day seminar is open for nine selected participants who will get the chance to learn neuropathology techniques and join a microscopy session. Where?: Institute of Neuropathology, Pottkamp 2, 48149 Muenster When?: April 26-27, 2018 flyer histopathology muenster 2018  ...more