Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl

Frauke Zipp


Mon, 06/02/2017
The role of ubiquitin in immunity
Mainz. “Regulating Ubiquitination and Disease” is the topic of Averil Mas lecture on 9th February 17 in Mainz. When?: Thursday, 02.02.2017, 17:15 bis 19:00 Where?: University Medical Center, Langenbeckstr. 1, Mainz Room: SR2 Prof. Ma is head of a reseach lab at the Helen Diller Family Comprehensive Cancer Center in San Francisco, USA. His research […]...more
Tue, 31/01/2017
Hartmut Wekerle explains the initiation of MS
Mainz. The FZI/FTN lecture series welcomes MS researcher Prof. Dr. Hartmut Wekerle (Munich) giving a talk entitled “Genesis – on the initiation of MS”. As emeritus director at the Max Planck Institute (MPI) of Neurobiology in Munich Prof. Wekerle has been honored with a senior professorship donated by the Hertie foundation which enables him to […]...more
Mon, 23/01/2017
Imaging Multiple Sclerosis – Lecture of Prof. Sven Shippling
Muenster. The Department of Neurology proudly presents Prof. Dr. Sven Schippling’s lecture on “Multiple Sclerosis phenotyping using multimodal imaging (MRI and OCT)” Date: January 11th, 2016 Time: 6:15 p.m. Place: Conference Room (05.603), Western Tower, University Clinic Muenster, Albert-Schweitzer-Campus 1, Gebäude A 1, 48149 Münster Prof. Schippling is principal investigator and co-director of the Clinical […]...more