Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl

Frauke Zipp


Thu, 09/11/2017
Elisabeth Schuh received SEED funding
Munich. SFB 128 researcher Elisabeth Schuh, MD, has been honoured by a young scientist’s studentship within the KKNMS SEED program. In her project „The role of the NLRP3 inflammasome in multiple sclerosis and experimental autoimmune encephalomyelitis“, Dr. Schuh analyses the influence of the NLRP3in MS. NLRP is a cytosolic protein complex in monocytes, macrophages and […]...more
Mon, 06/11/2017
Prof. Linington: Who needs a lymphocyte?
Mainz. SFB 128 researchers Prof. Jacky Trotter and Prof. Ari Waisman are proud to host Prof. Christopher Linington from the Institute of Infection, Immunity & Inflammation at the University of Glasgow for his lecture entitled “Who needs a lymphocyte? Non-immune-mediated demyelination in a novel model of progressive Multiple Sclerosis” Where?: Small Lecture Hall, Bldg 102, […]...more
Sun, 05/11/2017
The role of RANK-RANKL signaling
Muenster. Within the SFB 1009 Jour fixe meeting Prof. Dr. Karin Loser, PI of the SFB 1009 as well as 128, presents her project “The role of RANK-RANKL signaling for skin homeostasis and barrier function during anti-microbial immune responses”. Where?: Lecture Hall, Department of Dermatology, Von-Esmarch-Straße 58, Muenster When?: Monday, November 20, 1 pm...more