Welcome to the website for Transregional Collaborative Research Center (CRC) SFB TR-128 Initiating/effector versus regulatory mechanisms in Multiple Sclerosis – progress towards tackling the disease. On this site you will find general information regarding the CRC as well as more specific information about its individual research projects.

Multiple Sclerosis (MS) is the most common chronic inflammatory disease of the central nervous system (CNS) in the western world and it leads to devastating disability in young adults, with only limited treatment options currently available. The socioeconomic burden of this disease is tremendous, since healthcare costs are very high and it affects decisions young patients must make for the rest of their lives. Findings in patients are a complex composite of inflammation (with demyelination, remyelination, axonal/neuronal damage) typically in subcortical, but also cortical, disseminated lesions as well as neurodegeneration. Remissions of clinical relapses point to repair capacities of the CNS, which exhibits strong interindividual and course dependent differences.

Heinz Wiendl

Frauke Zipp


Fri, 12/08/2016
Symposium on Microbiota in Mainz on 05 Sep 2016
The Center for Thrombosis and Hemostasis (CTH) and the Research Center for Immunotherapy (FZI) Mainz have organized a symposium entitled “The indigenous microbiota Impact on immunity, vascular physiology & cardiovascular disease” taking place at Mainz University on September 5th – 6th, 2016. The conference brings together leading experts in the field of host microbial interactions […]...more
Fri, 12/08/2016
Joint SFB Meeting: Autoinflammation Breaks Barriers, Münster 20-22 Nov 2016
After a successful conference in 2014, we are pleased to announce that there will be a second international symposium on “Autoinflammation Breaks Barriers” taking place in Muenster. Scientists are cordially invited to listen to scientific lectures and to present their abstracts in the Max Planck Institute for Molecular Biomedicine, Münster, on November 20-22, 2016. This […]...more
Mon, 18/07/2016
18 July 2016: Nir Gov speaks about cell motility
On the 18 July 2016, Nir Gov from the Faculty of Chemistry in Revohot/Israel will come to Muenster to give a lecture on a “Theoretical model for persistant and oscillatory cell motility”. More information can be found here....more