2024

Afzali AM, Nirschl L, Sie C, Pfaller M, Ulianov O, Hassler T, Federle C, Petrozziello E, Kalluri SR, Chen HH, Tyystjärvi S, Muschaweckh A, Lammens K, Delbridge C, Büttner A, Steiger K, Seyhan G, Ottersen OP, Öllinger R, Rad R, Jarosch S, Straub A, Mühlbauer A, Grassmann S, Hemmer B, Böttcher JP, Wagner I, Kreutzfeldt M, Merkler D, Pardàs IB, Schmidt Supprian M, Buchholz VR, Heink S, Busch DH, Klein L, Korn T. 2024. B cells orchestrate tolerance to the neuromyelitis optica autoantigen AQP4. Nature. 627(8003):407-415.

Daguano Gastaldi V, Bh Wilke J, Weidinger CA, Walter C, Barnkothe N, Teegen B, Luessi F, Stöcker W, Lühder F, Begemann M, Zipp F, Nave KA, Ehrenreich H. 2024. Factors predisposing to humoral autoimmunity against brain-antigens in health and disease: Analysis of 49 autoantibodies in over 7000 subjects. Brain Behav Immun. 108:135-147.

Diddens J, Lepennetier G, Friedrich V, Schmidt M, Brand RM, Georgieva T, Hemmer B, Lehmann-Horn K. 2024. Single-Cell Profiling Indicates a Proinflammatory Role of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis. Neurol Neuroimmunol Neuroinflamm. 11(1):e200185.

Fleischer V°, Gonzalez-Escamilla G°, Pareto D, Rovira A, Sastre-Garriga J, Sowa P, Høgestøl EA, Harbo HF, Bellenberg B, Lukas C, Ruggieri S, Gasperini C, Uher T, Vaneckova M, Stefan Bittner S, Othman AE, Collorone S, Toosy AT, Meuth SG, Zipp F, Barkhof F, Ciccarelli O, Groppa S on behalf of the MAGNIMS study group. 2023. Prognostic value of single-subject grey matter networks in early multiple sclerosis. Brain 147: 135-146. (° = contributed equally)

Georgieva T°, Diddens J°, Friedrich V, Lepennetier G, Brand RM, Lehmann-Horn K. 2024. Single-cell profiling indicates a high similarity between immune cells in the cerebrospinal fluid and in meningeal ectopic lymphoid tissue in experimental autoimmune encephalomyelitis. Front Immunol. doi: 10.3389/fimmu.2024.1400641. (° = contributed equally)

Gross CC°* Schulte-Mecklenbeck A°, Steinberg OV°, Wirth T°, Lauks S°, Bittner S°, Schindler P, Baranzini SE, Groppa S, Bellmann-Strobl J, Bünger N, Chien C, Dawin E, Eveslage M, Fleischer V, Gonzalez-Escamilla G, Gisevius B, Haas J, Kerschensteiner M, Kirstein L, Korsukewitz C, Lohmann L, Lünemann JD, Luessi F, Meyer zu Hörste G, Motte J, Ruck T, Ruprecht K, Schwab N, Steffen F, Meuth SG, Paul F, Wildemann B, Kümpfel T, Gold R, Hahn T, Zipp F, Klotz L°*, Wiendl H°*, KKNMS. 2024. Multiple sclerosis endophenotypes identified by high-dimensional blood signatures are associated with distinct disease trajectories. Sci Transl Med. 16(740):eade8560. (° shared first/last authorship, * equal correspondence)

Howard JF Jr, Vu T, Mantegazza R, Kushlaf H, Suzuki S, Wiendl H, Beasley KN, Liao S, Meisel A; CHAMPION MG Study Group. 2024. Efficacy of ravulizumab in patients with generalized myasthenia gravis by time from diagnosis: A post hoc subgroup analysis of the CHAMPION MG study. Muscle Nerve. 69(5):556-565.

Kendirli A°, de la Rosa C°, Lämmle KF, Eglseer K, Bauer IJ, Kavaka V, Winklmeier S, Zhuo L, Wichmann C, Gerdes LA, Kümpfel T, Dornmair K, Beltrán E, Kerschensteiner M, Kawakami N. 2024. A genome-wide in vivo CRISPR screen identifies essential regulators of T cell migration to the CNS in a multiple sclerosis model. Nat Neurosci. 26(10):1713-1725.

Mezydlo A, Treiber N, Ullrich Gavilanes EM, Eichenseer K, Ancău M, Wens A, Ares Carral C, Schifferer M, Snaidero N, Misgeld T, Kerschensteiner M. 2024. Remyelination by surviving oligodendrocytes is inefficient in the inflamed mammalian cortex. Neuron 111(11):1748-1759.e8.

Oechtering J, Stein K, Schaedelin SA, Maceski AM, Orleth A, Meier S, Willemse E, Qureshi F, Heijnen I, Regeniter A, Derfuss T, Benkert P, D’Souza M, Limberg M, Fischer-Barnicol B, Achtnichts L, Mueller S, Salmen A, Lalive PH, Bridel C, Pot C, Du Pasquier RA, Gobbi C, Wiendl H, Granziera C, Kappos L, Trendelenburg M, Leppert D, Luenemann JD, Kuhle J; Swiss MS Cohort Study. 2024 Complement Activation Is Associated With Disease Severity in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 11(2):e200212.

Peters A, Gerdes LA, Wekerle H. 2024. Multiple sclerosis and the intestine: Chasing the microbial offender. Immunol Rev. doi: 10.1111/imr.13357 (Epub 2024 May 29).

Schaller-Paule MA, Maiworm M, Schäfer JH, Friedauer L, Hattingen E, Wenger KJ, Weber F, Jakob J, Steffen F, Bittner S, Yalachkov Y, Foerch C. 2024. Matching proposed clinical and MRI criteria of aggressive multiple sclerosis to serum and cerebrospinal fluid markers of neuroaxonal and glial injury. J Neurol. 271(6):3512-3526.

Schraad M, Runkel S, Hitzler W, Protopapa M, Bittner S, Uphaus T°, Zipp F°. 2024. Long-Term Observation of SARS-CoV-2 Vaccination Response upon High Efficacy Treatment in Multiple Sclerosis-A Real-World Scenario. Vaccines (Basel). 12(3):296. (°= contributed equally)

Vinnenberg L, Rychlik N, Oniani T, Williams B, White JA, Kovac S, Meuth SG, Budde T, Hundehege P. 2024. Assessing neuroprotective effects of diroximel fumarate and siponimod via modulation of pacemaker channels in an experimental model of remyelination. Exp Neurol.371:114572.

Wang AA°, Luessi F°, Neziraj T°, Pössnecker E°, Zuo M, Engel S, Hanuscheck N, Florescu A, Bugbee E, Ma XI, Rana F, Lee D, Ward LA, Kuhle J, Himbert J, Schraad M, Puijenbroek E, Klein C, Urich E, Ramaglia V, Pröbstel AK°, Zipp F°, Gommerman JL°. 2024. B cell depletion with anti-CD20 promotes neuroprotection in a BAFF-dependent manner in mice and humans. Sci Transl Med. 16(737):eadi0295.(° = contributed equally)

Wertheimer T°, Zwicky P°, Rindlisbacher L, Sparano C, Vermeer M, Silva de Melo BM, Haftmann C, Rückert T, Sethi A, Schärli S, Huber A, Ingelfinger F, Xu C, Kim D, Häne P, Fonseca da Silva A, Muschaweckh A, Nunez N, Krishnarajah S, Köhler N, Zeiser R, Oukka M, Korn T, Tugues S, Becher B. 2024. IL-23 stabilizes an effector Treg cell program in the tumor microenvironment. Nat Immunol. 25(3):512-524 (°= contributed equally)

Wicklein R, Kreitner L, Wild A, Aly L, Rueckert D, Hemmer B, Korn T, Menten MJ, Knier B. 2024. Retinal small vessel pathology is associated with disease burden in multiple sclerosis. Mult Scler. 30(7):812-819.

2023

Bauer IJ°, Fang P°, Lämmle KF, Tyystjärvi S, Alterauge D, Baumjohann D, Yoon H, Korn T, Wekerle H, Kawakami N. 2023. Visualizing the activation of encephalitogenic T cells in the ileal lamina propria by in vivo two-photon imaging. Proc Natl Acad Sci U S A doi: 10.1073/pnas.2302697120. (°= contributed equally)

Brahmer A, Geiß C, Lygeraki A, Neuberger E, Tzaridis T, Nguyen TT, Luessi F, Régnier-Vigouroux A, Hartmann G, Simon P, Endres K, Bittner S, Reiners KS, Krämer-Albers EM. 2023. Assessment of technical and clinical utility of a bead-based flow cytometry platform for multiparametric phenotyping of CNS-derived extracellular vesicles. Cell Commun Signal. 21(1):276.

Brummer T, Schillner M, Steffen F, Kneilmann F, Wasser B, Uphaus T, Zipp F, Bittner S. 2023. Spatial transcriptomics and neurofilament light chain reveal changes in lesion patterns in murine autoimmune neuroinflammation. J Neuroinflammation. 20(1):262.

Bittner S, Pape K, Klotz L, Zipp F. 2023. Implications of immunometabolism for smouldering MS pathology and therapy. Nat Rev Neurol. 19(8):477-488.

Boldrini VO, Mader S, Kümpfel T, Meinl E. 2023. Ublituximab: A new FDA-approved anti-CD20 mAb for relapsing forms of multiple sclerosis. Mult Scler Relat Disord. 75:104733.

Burmeister M°, Fraunenstein A°, Kahms M, Arends L, Gerwien H, Deshpande T, Kuhlmann T, Gross CC, Naik VN, Wiendl H, Klingauf J, Meissner F, Sorokin L. 2023. Secretomics reveals gelatinase substrates at the blood-brain barrier that are implicated in astroglial barrier function. Sci Adv. doi: 10.1126/sciadv.adg0686. (°= contributed equally)

Ciolac D, Gonzalez-Escamilla G, Winter Y, Fleischer V, Grothe M, Groppa S. 2023. Brain network correlates of epilepsy occurrence in multiple sclerosis and neuroinflammation. Neural Regen Res. 18(8):1717-1718.

Engel S, Halcour J, Ellwardt E, Uphaus T, Steffen F, Zipp F, Bittner S, Luessi F. 2023. Elevated neurofilament light chain CSF/serum ratio indicates impaired CSF outflow in idiopathic intracranial hypertension. Fluids Barriers CNS20(1):3.

Engel S, Klotz L, Wirth T, Fleck AK, Pickert G, Eschborn M, Kreuzburg S, Curella V, Bittner S, Zipp F, Schuppan D, Luessi F. 2023. Attenuation of immune activation in patients with multiple sclerosis on a wheat-reduced diet: a pilot crossover trial. Ther Adv Neurol Disord. 16:17562864231170928.

Gärtner Y, Bitar L, Zipp F, Vogelaar CF. 2023. Interleukin-4 as a therapeutic target. Pharmacol Ther. 242:108348.

Gonzalez-Escamilla G°, Chirumamilla VC°, Koirala N, Anwar AR, Tüscher O, Vogt J, Horstmann P, Meyer B, Bonanno GA, Groppa S°, Muthuraman M°. 2023. Modular segregation drives causality of the dynamic oscillatory network responses during threat processing. Brain Commun. 5(2):fcad035. (° = contributed equally)

Guedes JR*, Ferreira PA*, Costa J, Laranjo M, Pinto MJ, Reis T, Cardoso AM, Lebre C, Casquinha M, Gomes M, Shkatova V, Pereira M, Beltrão N, Hanuscheck N, Greenhalgh AD, Vogelaar CF, Carvalho AL, Zipp F, Cardoso AL, Peça J. 2023. IL-4 shapes microglia-dependent pruning of the cerebellum during postnatal development. Neuron 111(21):3435-3449.e8. (° = contributed equally)

Heming M, Wiendl H. 2023. Learning multiple sclerosis immunopathogenesis from anti-CD20 therapy. Proc Natl Acad Sci U S A. 120(6):e2221544120.2

Ho S, Oswald E, Wong HK, Vural A, Yilmaz V, Tüzün E, Türkoğlu R, Straub T, Meinl I, Thaler F, Kümpfel T, Meinl E°, Mader S°. 2023. Ocrelizumab Treatment Modulates B-Cell Regulating Factors in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 10(2):e200083. (° = contributed equally, share correspondence, co-senior authors)

Janoschka C, Lindner M, Koppers N, Starost L, Liebmann M, Eschborn M, Schneider-Hohendorf T, Windener F, Schafflick D, Fleck AK, Koch K, Deffner M, Schwarze AS, Schulte-Mecklenbeck A, Metz I, Meuth SG, Gross CC, Meyer Zu Hörste G, Schwab N, Kuhlmann T, Wiendl H, Stoll M, Klotz L. 2023. Enhanced pathogenicity of Th17 cells due to natalizumab treatment: Implications for MS disease rebound. Proc Natl Acad Sci U S A. 120(1):e2209944120.

Kapell H°, Fazio L°, DyckowJ°, SchwarzS, Cruz-Herranz A, Campos J, Mayer C, D´Este E, Möbius W, Cordano C, Pröbstel A-K, Gharagozloo M, Zulji A, Narayanan Naik V, Delank A, Cerina M, Müntefering T, Lerma-Martin C, Sonner JK, Hyung Sin J, Disse P, Rychlik N, Sabeur K, Chavali M, Srivastava R, Heidenreich M, Fitzgerald KC, Seebohm G, Stadelmann C, Hemmer B, Platten M, Jentsch TJ, Engelhardt M, Budde T, Nave K-A, Calabresi PA, Friese MA, Green AJ, Acuna C, Rowitch DH*, Meuth SG*, Schirmer L*. 2023. Neuron-oligodendrocyte potassium shuttling at nodes of Ranvier protects against inflammatory demyelination. J Clin Invest. 133(7):e164223. (° = contributed equally; * = share correspondence)

Klotz L, Antel J, Kuhlmann T. 2023. Inflammation in multiple sclerosis: consequences for remyelination and disease progression. Nat Rev Neurol. 19(5):305-320.

Konken CP, Beutel B, Schinor B, Song J, Gerwien H, Korpos E, Burmeister M, Riemann B, Schäfers M, Sorokin L, Haufe G. 2023. Influence of N-arylsulfonamido d-valine N-substituents on the selectivity and potency of matrix metalloproteinase inhibitors. Bioorg Med Chem. 90:117350.

Korn T. 2023. Foxp3+ regulatory T cells in the central nervous system and other nonlymphoid tissues. Eur J Immunol. 253(8):e2250227.

Krämer J, Bar-Or A, Wiendl H. 2023.Bruton tyrosine kinase inhibitors for multiple sclerosis. Nat Rev Neurol.19(5):289-304.

Kuhlmann T, Moccia M, Coetzee T, Cohen JA, Correale J, Graves J, Marrie RA, Montalban X, Yong VW Thompson AJ, Reich DS. 2023. Multiple sclerosis progression: time for a new mechanism-driven framework. Lancet Neurol. 22(1):78-88.

Lutfullin I , Eveslage M, Bittner S, Antony G, Flaskamp M, Luessi F, Salmen A, Gisevius B, Klotz L, Korsukewitz C, Berthele A, Groppa S, Then Bergh F, Wildemann B, Bayas A, Tumani H, Meuth SG, Trebst C, Zettl UK, Paul F, Heesen C, Kuempfel T, Gold R, Hemmer B, Zipp F, Wiendl H, Lünemann JD; German Competence Network Multiple Sclerosis (KKNMS). 2023. Association of obesity with disease outcome in multiple sclerosis. J Neurol Neurosurg Psychiatry 94(1):57-61.

Molina-Gonzalez I, Holloway RK, Jiwaji Z, Dando O, Kent SA, Emelianova K, Lloyd AF, Forbes LH, Mahmood A, Skripuletz T, Gudi V, Febery JA, Johnson JA, Fowler JH, Kuhlmann T, Williams A, Chandran S, Stangel M, Howden AJM, Hardingham GE, Miron VE. 2023. Astrocyte-oligodendrocyte interaction regulates central nervous system regeneration. Nat Commun. 14(1):3372.

Muthuraman M, Oshaghi M, Fleischer V, Ciolac D, Othman A, Meuth SG, Gonzalez-Escamilla G, Groppa S. 2023. Choroid plexus imaging to track neuroinflammation – a translational model for mouse and human studies. Neural Regen Res. 18(3):521-522.

Pape K, Protopapa M, Schraad M, Steffen F, Zipp F, Bittner S. 2023. Case Report: Balancing immune responses – multiple sclerosis disease exacerbation under BRAF/MEK treatment for malignant melanoma. Front Oncol. 13:1303141.

Schneider-Hohendorf T, Wiendl H. 2023. Targeting MCAM for next generation of leucocyte trafficking (commentary). Brain 146(4):1236-1237.

Schraad M, Uphaus T, Runkel S, Hitzler W, Bittner S, Zipp F. 2023. Predictors for insufficient SARS-CoV-2 vaccination response upon treatment in multiple sclerosis. EBioMedicine. 87:104411.

Spatola M°, Chuquisana O°, Jung W, Lopez JA, Wendel EM, Ramanathan S, Keller CW, Hahn T, Meinl E, Reindl M, Dale RC, Wiendl H, Lauffenburger DA, Rostásy K, Brilot F, Alter G°, Lünemann JD°. 2023. Humoral signatures of MOG-antibody-associated disease track with age and disease activity. Cell Rep Med. 4(2):100913. (° = contributed equally)

Stascheit F°, Chuquisana O°, Keller CW, Ambrose PA, Hoffmann S, Gross CC, Lehnerer S, Wiendl H, Willcox N°, Meisel A°, Lünemann JD°. 2023. Complement activation profiles in anti-acetylcholine receptor positive myasthenia gravis. Eur J Neurol. 30(5):1409-1416. (° = contributed equally, share first/last authorship)

Steffen F°, Uphaus T°, Ripfel N, Fleischer V, Schraad M, Gonzalez-Escamilla G, Engel S, Groppa S, Zipp F°, Bittner S°. 2023. Serum Neurofilament Identifies Patients With Multiple Sclerosis With Severe Focal Axonal Damage in a 6-Year Longitudinal Cohort. Neurol Neuroimmunol Neuroinflamm. 10(1):e200055. (° = contributed equally, share first/last authorship)

Tai YH, Engels D, Locatelli G, Emmanouilidis I, Fecher C, Theodorou D, Müller SA, Licht-Mayer S, Kreutzfeldt M, Wagner I, de Mello NP, Gkotzamani SN, Trovò L, Kendirli A, Aljović A, Breckwoldt MO, Naumann R, Bareyre FM, Perocchi F, Mahad D, Merkler D, Lichtenthaler SF, Kerschensteiner M°, Misgeld T°. 2023. Targeting the TCA cycle can ameliorate widespread axonal energy deficiency in neuroinflammatory lesions. Nat Metab. 5(8):1364-1381.

Thomann AS, McQuade CA, Pinjušić K, Kolz A, Schmitz R, Kitamura D, Wekerle H, Peters A. 2023. A B cell-driven EAE mouse model reveals the impact of B cell-derived cytokines on CNS autoimmunity. Proc Natl Acad Sci U S A. 120(47):e2300733120.

Vataman A, Ciolac D, Chiosa V, Aftene D, Leahu P, Winter Y, Groppa SA, Gonzalez-Escamilla G, Muthuraman M°, Groppa S°. 2023. Dynamic flexibility and controllability of network communities in juvenile myoclonic epilepsy. Neurobiol Dis. 179:106055. (° = contributed equally)

Windener F, Grewing L, Thomas C, Dorion MF, Otteken M, Kular L, Jagodic M, Antel J, Albrecht S, Kuhlmann T. 2024. Physiological aging and inflammation-induced cellular senescence may contribute to oligodendroglial dysfunction in MS. Acta Neuropathol. 147(1):82.

Yilmaz EN, Albrecht S, Groll K, Thomas C, Wallhorn L, Herold M, Hucke S, Klotz L, Kuhlmann T. 2023. Influx of T cells into corpus callosum increases axonal injury, but does not change the course of remyelination in toxic demyelination. Glia. 71(4):991-1001.

Zhao X, Jacob C. 2023. Mechanisms of Demyelination and Remyelination Strategies for Multiple Sclerosis. Int J Mol Sci. 24(7):6373.

Zipp F, Bittner S, Schafer DP. 2023. Cytokines as emerging regulators of central nervous system synapses. Immunity. 56(5):914-925.

2022

Afzali AM, Stüve L, Pfaller M, Aly L, Steiger K, Knier B, Korn K. 2022. Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation. J Mol Med (Berl)100(6):933-946.

Aly L°, Strauß EM°, Feucht N, Weiß I, Berthele A, Mitsdoerffer M, Haass C, Hemmer B, Maier M, Korn T°, Knier B°. 2022. Optical coherence tomography angiography indicates subclinical retinal disease in neuromyelitis optica spectrum disorders. Mult Scler. 28(4):522-531. (° = equally contributing, shared first/last authorship)

Benkhoucha M, Tran NL, Breville G, Senoner I, Bradfield PF, Papayannopoulou T, Merkler D, Korn T, Lalive PH. 2022. CD4+c-Met+Itgα4+ T cell subset promotes murine neuroinflammation. J Neuroinflammation 19(1):103.

Bitar L°, Uphaus T°, Thalman C°, Muthuraman M, Gyr L, Ji H, Domingues M, Endle H, Groppa S, Steffen F, Koirala N, Fan W, Ibanez L, Heitsch L, Cruchaga C, Lee J-M, Kloss F, Bittner S, Nitsch R*, Zipp F*, Vogt HJ*. 2022. Inhibition of the enzyme autotaxin reduces cortical excitability and ameliorates the outcome in stroke. Sci Transl Med. 14(641):eabk0135. (° = equal contribution, shared first authorship * = equal contribution, shared last authorship)

Bittner S, Zipp F 2022. Progression in multiple sclerosis – a long-term problem. Curr Opin Neurol. 35(3):293-298.

Brummer T, Muthuraman M, Steffen F, Uphaus T, Minch L, Person M, Zipp F, Groppa S, Bittner S, Fleischer V. 2022. Improved prediction of early cognitive impairment in multiple sclerosis combining blood and imaging biomarkers. Brain Commun. 4(4):fcac153.

Brummer T, Ruck T, Meuth SG, Zipp F, Bittner S. 2022. Treatment approaches to patients with multiple sclerosis and coexisting autoimmune disorders. Ther Adv Neurol Disord. 14:17562864211035542.

Cantuti-Castelvetri L, Gokce O, Simons M. 2022. Reparative inflammation in multiple sclerosis. Semin Immunol. 59:101630.

Chaudhary R, Albrecht S, Datunashvili M, Cerina M, Lüttjohann A, Han Y, Narayanan V, Chetkovich DM, Ruck T, Kuhlmann T, Pape HC, Meuth SG, Zobeiri M, Budde T. 2022. Modulation of Pacemaker Channel Function in a Model of Thalamocortical Hyperexcitability by Demyelination and Cytokines. Cereb Cortex 32(20):4397-4421.

Chuquisana O, Strippel C, Gross CC, Melzer N, Kühn J, Kovac S, Wiendl H, Lünemann JD. 2022. Antibody response to herpes simplex virus-1 is increased in autoimmune encephalitis. Eur J Immunol. 52(7):1198-1200.

Ciolac D°, Gonzalez-Escamilla G°, Winter Y, Melzer N, Luessi F, Radetz A, Fleischer V, Groppa SA, Kirsch M, Bittner S, Zipp F, Muthuraman M, Meuth SG, Grothe M, Groppa S. 2022. Altered grey matter integrity and network vulnerability relate to epilepsy occurrence in patients with multiple sclerosis. Eur J Neurol. 29(8):2309-2320. (° = equally contributing)

Coronel-Castello SP°, Lepennetier G°, Diddens J, Friedrich V, Pfaller M, Hemmer B, Lehmann-Horn K. 2022. Intrathecally Expanding B Cell Clones in Herpes Simplex Encephalitis: A Case Report. Neurol Ther. 11(2):905-913. (° = equally contributing)

Ding H, Groppa S, Muthuraman M. 2022. Toward future adaptive deep brain stimulation for Parkinson’s disease: the novel biomarker – narrowband gamma oscillation. Neural Regen Res. 17(3):557-558.

Ellwardt E°, Muthuraman M°, Gonzalez-Escamilla G, Chirumamilla VC, Luessi F, Bittner S, Zipp F, Groppa S, Fleischer V. 2022. Network alterations underlying anxiety symptoms in early multiple sclerosis. J Neuroinflammation. 24;19(1):119. (° = equally contributing, shared first authorship)

Engel S, Zipp F. 2022. Preventing disease progression in multiple sclerosis-insights from large real-world cohorts. Genome Med. 44(1):41.

Fleischer V, Ciolac D, Gonzalez-Escamilla G, Grothe M, Strauss S, Molina Galindo LS, Radetz A, Salmen A, Lukas C, Klotz L, Meuth SG, Bayas A, Paul F, Hartung HP, Heesen C, Stangel M, Wildemann B, Then Bergh F, Tackenberg B, Kümpfel T, Zettl UK, Knop M, Tumani H, Wiendl H, Gold R, Bittner S, Zipp F, Groppa S, Muthuraman M, German Competence Network Multiple Sclerosis (KKNMS). 2022. Subcortical Volumes as Early Predictors of Fatigue in Multiple Sclerosis. Ann Neurol. 91(2):192-202.

Gil-Pulido J, Amézaga N, Jorgacevic I, Manthey HD, Rösch M, Brand T, Cidlinsky P, Schäfer S, Beilhack A, Saliba AE, Lorenz K, Boon L, Prinz I, Waisman A, Korn T, Cochain C, Zernecke A. 2022. Interleukin-23 receptor expressing γδ T cells locally promote early atherosclerotic lesion formation and plaque necrosis in mice. Cardiovasc Res. 118(14):2932-2945.

Hanuscheck N°, Thalman C°, Domingues M°, Schmaul S, Muthuraman M, Hetsch F, Ecker M, Endle H, Oshaghi M, Martino G, Kuhlmann T, Bozek K, Beers T, Bittner S, Engelhardt J, Vogt J°, Vogelaar CF°, Zipp F°. 2022. Interleukin-4 receptor signaling modulates neuronal network activity. J Exp Med. 219(6):e20211887. (°=equally contributing)

Holm Hansen R, Talbot J, Højsgaard Chow H, Bredahl Hansen M, Buhelt S, Herich S, Schwab S, Nickelsen Hellem MN, Nielsen JE, Sellebjerg F, Rode von Essen M. 2022. Increased Intrathecal Activity of Follicular Helper T Cells in Patients With Relapsing-Remitting Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 9(5):e200009.

Hossen A, Anwar AR, Koirala N, Ding H, Budker D, Wickenbrock A, Heute U, Deuschl G, Groppa S, Muthuraman M. 2022. Machine learning aided classification of tremor in multiple sclerosis. EBioMedicine 82:104152.

Huntemann N, Bittner S, Bock S, Meuth SG, Ruck T. 2022. Mini-Review: Two Brothers in Crime – The Interplay of TRESK and TREK in Human Diseases. Neurosci Lett. 769:136376.

Keller CW, Chuquisana O, Derdelinckx J, Gross CC, Berger K, Robinson, Nimmerjahn, Wiendl, Willcox N Lünemann JD. 2022. Impaired B Cell Expression of the Inhibitory Fcγ Receptor IIB in Myasthenia Gravis. Ann Neurol. 92(6): 1046-1051.

Mader S, Kümpfel T, Meinl E. 2022. Pathomechanisms in demyelination and astrocytopathy: autoantibodies to AQP4, MOG, GFAP, GRP78 and beyond. Curr Opin Neurol. 35(3):427-435.

Maisam Afzali A, Stüve L, Pfaller M, Aly L, Steiger K, Knier B, Korn T. 2022. Aquaporin-4 prevents exaggerated astrocytosis and structural damage in retinal inflammation. J Mol Med (Berl). 100(6):933-946.

Mariottini A, Muraro PA, Lünemann JD. 2022. Antibody-mediated cell depletion therapies in multiple sclerosis. Curr Opin Neurol. 13:953649.

Oniani T°, Vinnenberg L°, Chaudhary R, Schreiber JA, Riske K, Williams B, Pape HC, White JA, Junker A, Seebohm G, Meuth SG, Hundehege P, Budde T°, Zobeiri M°. 2022. Effects of Axonal Demyelination, Inflammatory Cytokines and Divalent Cation Chelators on Thalamic HCN Channels and Oscillatory Bursting. Int J Mol Sci. 23(11):6285. (°=contributed equally)

Ostkamp P, Deffner M, Schulte-Mecklenbeck A, Wünsch C, Lu IN, Wu GF, Goelz S, De Jager PL, Kuhlmann T, Gross CC, Klotz L, Meyer Zu Hörste G, Wiendl H°, Schneider-Hohendorf T°, Schwab N°. 2022. a href=”http://dx.doi.org/10.1126/scitranslmed.adc9778″> A single-cell analysis framework allows for characterization of CSF leukocytes and their tissue of origin in multiple sclerosis. Sci Transl Med. 14(673):eadc9778. (° = contributed equally)

Ostkamp P, Schwab N. 2022. Effects of Latitude and Sunlight on Multiple Sclerosis Severity: Two Peas in a Pod? Neurology 98(24):997-998.

Ruck T°, Barman S°, Schulte-Mecklenbeck A°, Pfeuffer S, Steffen F, Nelke C, Schroeter CB, Willison A, Heming M, Müntefering T, Melzer N, Krämer J, Lindner M, Riepenhausen M, Gross CC, Klotz L, Bittner S, Muraro PA, Schneider-Hohendorf T, Schwab N, Meyer Zu Hörste G, Goebels N°, Meuth SG°, Wiendl H°. 2022. Alemtuzumab-induced immune phenotype and repertoire changes: implications for secondary autoimmunity. Brain. 145(5):1711-1725. (°= contributed equally)

Ruck T°, Bock S°, Pfeuffer S, Schroeter CB, Cengiz D, Marciniak P, Lindner M, Herrmann A, Liebmann M, Kovac S, Gola L, Rolfes L, Pawlitzki M, Opel N, Hahn T, Dannlowski U, Pap T, Luessi F, Schreiber JA, Wünsch B, Kuhlmann T, Seebohm G, Tackenberg B, Seja P, Döring F, Wischmeyer E, Chasan AI, Roth J, Klotz L, Meyer Zu Hörste G, Wiendl H, Marschall T, Floess S, Huehn J, Budde T, Bopp T, Bittner S, Meuth SG. 2022 K 2P 18.1 translates T cell receptor signals into thymic regulatory T cell development. Cell Res. 32(1):72-88.

Ruck T, Nimmerjahn F, Wiendl H, Lünemann JD. 2022. Next generation antibody-based therapies in neurology. Brain 145(4):1229-1241.

Trümpelmann S°, Schulte-Mecklenbeck A°, Steinberg OV, Wirth T, Fobker M, Lohmann L, Lünemann JD, Wiendl H, Gross CC°, Klotz L°. 2022. Impact of disease-modifying therapies on humoral and cellular immune-responses following SARS-CoV-2 vaccination in MS patients. Clin Transl Sci. 15(7):1606-1612.(°= contributed equally)

2021

Aulova KS, Urusov AA, Sedykh SE, Toporkova LB, Lopatnikova JA, Buneva VN, Sennikov SV, Budde T, Meuth SG, Popova NA, Orlovskaya IA, Nevinsky GA. 2021. The association between EAE development in mice and the production of autoantibodies and abzymes after immunization of mice with different antigens. J Cell Mol Med. 25(5):2493-2504.

Bahr K, Geisler V, Huppertz T, Groppa S, Matthias C, Gouveris H, Muthuraman M. 2021. Intensity of Respiratory Cortical Arousals Is a Distinct Pathophysiologic Feature and Is Associated with Disease Severity in Obstructive Sleep Apnea Patients. Brain Sci. 11(3):282.

Bange M, Groppa S, Muthuraman M. 2021. Nonlinear irregularities in Parkinson’s disease tremor and essential tremor. Clin Neurophysiol. 132(9):2255-2256.

Bellmann-Strobl J°, Paul F°, Wuerfel J, Dorr J, Infante-Duarte C, Heidrich E, Kortgen B, Brandt A, Pfuller C, Radbruch H, Rust R, Siffrin V, Aktas O, Heesen C, Faiss J, Hoffmann F, Lorenz M, Zimmermann B, Groppa S, Wernecke KD, Zipp F. Epigallocatechin Gallate in Relapsing-Remitting Multiple Sclerosis A Randomized, Placebo-Controlled Trial. Neurol Neuroimmunol Neuroinflamm. 8(3):e981. (° = contributed equally)

Bittner S, Oh J, Havrdová EK, Tintoré M, Zipp F. 2021. The potential of serum neurofilament as biomarker for multiple sclerosis. Brain 144(10):2954-2963.

Bittner S, Zipp F. 2021. A lymphocyte-glia connection sets the pace for smoldering inflammation. Cell184(23):5696-5698.

Bock M, Steffen F, Zipp F, Bittner S. 2021. Impact of Dietary Intervention on Serum Neurofilament Light Chain in Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 9(1):e1102.

Brand RM, Diddens J, Friedrich V, Pfaller M, Radbruch H, Hemmer B, Steiger K, Lehmann-Horn K. 2021. Siponimod Inhibits the Formation of Meningeal Ectopic Lymphoid Tissue in Experimental Autoimmune Encephalomyelitis. Neurol Neuroimmunol Neuroinflamm. 9(1):e1117.

Brand RM, Friedrich V, Diddens J, Pfaller M, Romana de Franchis F, Radbruch H, Hemmer B, Steiger K, Lehmann-Horn K. 2021. Anti-CD20 Depletes Meningeal B Cells but Does Not Halt the Formation of Meningeal Ectopic Lymphoid Tissue. Neurol Neuroimmunol Neuroinflamm. 8(4):e1012.

Brändle SM°, Cerina M°, Weber S°, Held K, Menke AF, Alcalá C, Gebert D, Herrmann AM, Pellkofer H, Gerdes LA, Bittner S, Leypoldt F, Teegen B, Komorowski L, Kümpfel T, Hohlfeld R, Meuth SG, Casanova B, Melzer N°, Beltrán E°, Dornmair K°. 2021. Cross-reactivity of a pathogenic autoantibody to a tumor antigen in GABA(A) receptor encephalitis. Proc Natl Acad Sci U S A. 118(9):e1916337118. (° = equally contributing)

Chanoumidou K, Hernandez-Rodriguez B, Windener F, Thomas C, Stehling M, Mozafari S, Albrecht S, Ottoboni L, Antel J, Kim KP, Velychko S, Cui QL, Xu YKT, Martino G, Winkler J, Scholer HR, Baron-Van Evercooren A, Boespflug-Tanguy O, Vaquerizas JM, Ehrlich M, Kuhlmann T. 2021. One-step Reprogramming of Human Fibroblasts into Oligodendrocyte-like Cells by SOX10, OLIG2, and NKX6.2. Stem Cell Reports 16(4):771-783.

Ciolac D, Gonzalez-Escamilla G, Radetz A, Fleischer V, Person M, Johnen A, Landmeyer NC, Kramer J, Muthuraman M, Meuth SG, Groppa S. 2021. Sex-specific signatures of intrinsic hippocampal networks and regional integrity underlying cognitive status in multiple sclerosis. Brain Commun. 3(3):fcab198.

Colombo E, Horta G, Roesler MK, Ihbe N, Chhabra S, Radyushkin K, Di Liberto G, Kreutzfeldt M, Schumann S, von Engelhardt J, Merkler D, Behl C, Mittmann T, Clement AM, Waisman A, Schmeisser MJ. 2021. The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling. Proc Natl Acad Sci U S A. 118(47):e2110755118.

Engel S, Boedecker S, Marczynski P, Bittner S, Steffen F, Weinmann A, Schwarting A, Zipp F, Weinmann-Menke J, Luessi F. 2021. Association of serum neurofilament light chain levels and neuropsychiatric manifestations in systemic lupus erythematosus. Ther Adv Neurol Disord. 14:17562864211051497.

Engel S°, Jolivel V°, Kraus SHP, Zayoud M, Rosenfeld K, Tumani H, Furlan R, Kurschus FC, Waisman A, Luessi F. 2021. Laquinimod dampens IL-1β signaling and Th17-polarizing capacity of monocytes in patients with MS. Neurol Neuroimmunol Neuroinflamm. 8(1):e908. (° = contributed equally)

Engel S°, Protopapa M°, Steffen F, Papanastasiou V, Nicolaou C, Protopapas M, Zipp F, Bittner S, Luessi F. 2021. Implications of extreme serum neurofilament light chain levels for the management of patients with relapsing multiple sclerosis. Ther Adv Neurol Disord. 14:17562864211001977.(° = contributed equally)

Eschborn M°, Pawlitzki M°, Wirth T, Nelke C, Pfeuffer S, Schulte-Mecklenbeck A, Lohmann L, Rolfes L, Pape K, Eveslage M, Bittner S, Gross CC, Ruck T, Wiendl H, Meuth SG°, Klotz L°. 2021. Evaluation of Age-Dependent Immune Signatures in Patients With Multiple Sclerosis. Neurol Neuroimmunol Neuroinflamm. 8(6):e1094. (° = equally contributing)

Fleck AK, Hucke S, Teipel F, Eschborn M, Janoschka C, Liebmann M, Wami H, Korn L, Pickert G, Hartwig M, Wirth T, Herold M, Koch K, Falk-Paulsen M, Dobrindt U, Kovac S, Gross CC, Rosenstiel P, Trautmann M, Wiendl H, Schuppan D, Kuhlmann T, Klotz L. 2021. Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity. Brain 144(4):1152-1166.

Fleischer V°, Gonzalez-Escamilla G°, Ciolac D, Albrecht P, Kury P, Gruchot J, Dietrich M, Hecker C, Muntefering T, Bock S, Oshaghi M, Radetz A, Cerina M, Kramer J, Wachsmuth L, Faber C, Lassmann H, Ruck T, Meuth SG, Muthuraman M, Groppa S. 2021. Translational value of choroid plexus imaging for tracking neuroinflammation in mice and humans. Proc Natl Acad Sci U S A. 118(36):e2025000118. (°= contributed equally)

Fransen NL, de Jong BA, Heß K, Kuhlmann T, Vincenten MCJ, Hamann J, Huitinga I, Smolders J. 2021. Absence of B Cells in Brainstem and White Matter Lesions Associates With Less Severe Disease and Absence of Oligoclonal Bands in MS. Neurol Neuroimmunol Neuroinflamm. 8(2):e955.

Gerhards R, Pfeffer LK, Lorenz J, Starost L, Nowack L, Thaler FS, Schlüter M, Rübsamen H, Macrini C, Winklmeier S, Mader S, Bronge M, Grönlund H, Feederle R, Hsia HE, Lichtenthaler SF, Merl-Pham J, Hauck SM, Kuhlmann T, Bauer IJ, Beltran E, Gerdes LA, Mezydlo A, Bar-Or A, Banwell B, Khademi M, Olsson T, Hohlfeld R, Lassmann H, Kümpfel T, Kawakami N, Meinl E. 2020. Oligodendrocyte myelin glycoprotein as a novel target for pathogenic autoimmunity in the CNS. Acta Neuropathol Commun. 8(1):207.

Gonzalez-Escamilla G°, Groppa S°. 2021. 7 Tesla MRI will soon be helpful to guide clinical practice in multiple sclerosis centres – No. Mult Scler. 27(3):362-363. (°= contributed equally)

Gouna G, Klose C, Bosch-Queralt M, Liu L, Gokce O, Schifferer M, Cantuti-Castelvetri L, Simons M. 2021. TREM2-dependent lipid droplet biogenesis in phagocytes is required for remyelination. J Exp Med. 218(10):e20210227.

Groppa S°, Gonzalez-Escamilla G°, Eshaghi A, Meuth SG, Ciccarelli O. Brain Commun. 2021. Linking immune-mediated damage to neurodegeneration in multiple sclerosis: could network-based MRI help? Brain Commun. 3(4):fcab237. (°= contributed equally)

Gross CC, Schulte-Mecklenbeck A, Madireddy L, Pawlitzki M, Strippel C, Räuber S, Krämer J, Rolfes L, Ruck T, Beuker C, Schmidt-Pogoda A, Lohmann L, Schneider-Hohendorf T, Hahn T, Schwab N, Minnerup J, Melzer N, Klotz L, Meuth SG, Hörste GMZ, Baranzini SE, Wiendl H. 2021. Classification of neurological diseases using multi-dimensional cerebrospinal fluid analysis. Brain 144(9):2625-2634.

Gurusamy M, Tischner D, Shao J, Klatt S, Zukunft S, Bonnavion R, Günther S, Siebenbrodt K, Kestner RI, Kuhlmann T, Fleming I, Offermanns S, Wettschureck N. 2021. G-protein-coupled receptor P2Y10 facilitates chemokine-induced CD4 T cell migration through autocrine/paracrine mediators. Nat Commun. 12(1):6798.

Haase S, Mäurer J, Duscha A, Lee DH, Balogh A, Gold R, Müller DN, Haghikia A, Linker RA. 2021. Propionic Acid Rescues High-Fat Diet Enhanced Immunopathology in Autoimmunity via Effects on Th17 Responses. Front Immunol. 12:701626.

Haftmann C, Zwicky P°, Ingelfinger F°, Mair F, Floess S, Riedel R, Durek P, Spalinger MR, Friebel E, Leung BP, Lutz M, Puertas N, Amorim A, Schärli S, Becher Be, Kisielow J, Waisman A, Mashreghi M-F, Huehn J, Becher B. 2021. Protection against autoimmunity is driven by thymic epithelial cell-mediated regulation of T reg development. Sci Immunol. 6(65):eabf3111.

Hartlehnert M, Börsch A-L, Li X, Burmeister M, Gerwien H, Schafflick D, Heming M, Lu I-N, Narayanan V, Strecker J-K, Kolz A, Peters, Wu GF, Wiendl H, Sorokin L, Meyer Zu Horste G. 2021. Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation. Proc Natl Acad Sci U S A 118(36):e2023174118.

Heming M, Li X, Räuber S, Mausberg AK, Börsch A-L, Hartlehnert M, Singhal A, Lu I-N, Fleischer M, Szepanowski F, Witzke O, Brenner T, Dittmer U, Yosef N, Kleinschnitz C, Wiendl H, Stettner M, Meyer zu Hörste G. 2021. Neurological Manifestations of COVID-19 Feature T Cell Exhaustion and Dedifferentiated Monocytes in Cerebrospinal Fluid. Immunity 54(1):164-175.e6.

Hiltensperger M, Beltraen E, Kant R, Tyystjaervi S, Lepennetier G, Moreno HD, Bauer IJ, Grassmann S, Jarosch S, Schober K, Buchholz VR, Kenet S, Gasperi C, Oellinger R, Rad R, Muschaweckh A, Sie C, Aly L, Knier B, Garg G, Afzali AM, Gerdes LA, Kuempfel T, Franzenburg S, Kawakami N, Hemmer B, Busch DH, Misgeld T, Dornmair K, Korn T. 2021. Skin and gut imprinted helper T cell subsets exhibit distinct functional phenotypes in central nervous system autoimmunity. Nat Immunol. 22(7):880-892.

Irani SR, Nath A, Zipp F. 2021. The neuroinflammation collection: a vision for expanding neuro-immune crosstalk in Brain. Brain 144(7):e59.

Jafari M, Schumacher AM, Snaidero N, Gavilanes EMU, Neziraj T, Kocsis-Jutka V, Engels D, Jurgens T, Wagner I, Weidinger JDF, Schmidt SS, Beltran E, Hagan N, Woodworth L, Ofengeim D, Gans J, Wolf F, Kreutzfeldt M, Portugues R, Merkler D, Misgeld T, Kerschensteiner M. 2021. Phagocyte-mediated synapse removal in cortical neuroinflammation is promoted by local calcium accumulation. Nat Neurosci. 24(3):355-367.

Karsdal MA, Kraus VB, Shevell D, Bay-Jensen AC, Schattenberg J, Surabattula RR, Schuppan D. 2021. Profiling and targeting connective tissue remodeling in autoimmunity – A novel paradigm for diagnosing and treating chronic diseases. Autoimmun Rev. 20(1):102706.

Keller CW, Lopez JA, Wendel EM, Ramanathan S, Gross CC, Klotz L, Reindl M, Dale RC, Wiendl H, Rostásy K, Brilot F, Lünemann JD. 2021. Complement Activation Is a Prominent Feature of MOGAD. Ann Neurol. 90(6):976-982.

Keller CW, Oechtering J, Wiendl H, Kappos L, Kuhle J, Lünemann JD. 2021. Impact of complement activation on clinical outcomes in multiple sclerosis. Ann Clin Transl Neurol. 8(4):944-950.

Korn T, Hiltensperger M. 2021. Role of IL-6 in the commitment of T cell subsets. Cytokine 146:155654.

Krienke C, Kolb L, Diken E, Streuber M, Kirchhoff S, Bukur T, Akilli-Öztürk Ö, Kranz LM, Berger H, Petschenka J, Diken M, Kreiter S, Yogev N, Waisman A, Karikó K, Türeci Ö, Sahin U. 2021. A noninflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis. Science371(6525):145-153.

Larochelle C, Wasser B, Jamann H, Löffel JT, Cui Q-L, Tastet O, Schillner M, Luchtman D, Birkenstock J, Stroh A, Antel J, Bittner S, Zipp F. 2021. Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation. Proc Natl Acad Sci U S A. 118(34):e2025813118.

Liebmann M, Korn L, Janoschka C, Albrecht S, Lauks S, Herrmann AM, Schulte-Mecklenbeck A, Schwab N, Schneider-Hohendorf T, Eveslage M, Wildemann B, Luessi F, Schmidt S, Diebold M, Bittner S, Gross CC, Kovac S, Zipp F, Derfuss T, Kuhlmann T, König S, Meuth SG, Wiendl H, Klotz L. 2021. Dimethyl fumarate treatment restrains the antioxidative capacity of T cells to control autoimmunity. Brain. 144(10):3126-3141.

Litvak V, Florin E, Tamas G, Groppa S, Muthuraman M. 2021. EEG and MEG primers for tracking DBS network effects. Neuroimage. 224: 117447.

Liu J, Mori M, Zimmermann H, Brandt A, Havla J, Tanaka S, Sugimoto K, Oji S, Uzawa A, Asseyer S, Cooper G, Jarius S, Bellmann-Strobl J, Ruprecht K, Siebert N, Masuda H, Uchida T, Ohtani R, Nomura K, Meinl E, Kuempfel T, Paul F, Kuwabara S. 2021. Anti-MOG antibody-associated disorders: differences in clinical profiles and prognosis in Japan and Germany. J Neurol Neurosurg Psychiatry. doi: 10.1136/jnnp-2020-324422

Lohmann L, Lammerskitten A, Korsen M, Dodel R, Gaul C, Hamer HM, Kleineberg NN, Ludolph AC, Mayer G, Poli S, Saur D, Steinhoff BJ, Timmermann L, Klotz L, Meuth SG. 2021. Status of clinical research in neurology in Germany-A national survey. Eur J Neurol. 28(5):1446-1452.

Macrini C, Gerhards R, Winklmeier S, Bergmann L, Mader S, Spadaro M, Vural A, Smolle M, Hohlfeld R, Kümpfel T, Lichtenthaler SF, Franquelim HG, Jenne D, Meinl E. 2021. Features of MOG required for recognition by patients with MOG antibody-associated disorders. Brain 144(8):2375-2389.

Mahler C, Schumacher AM, Unterrainer M, Kaiser L, Höllbacher T, Lindner S, Havla J, Ertl-Wagner B, Patzig M, Seelos K, Neitzel J, Mäurer M, Krumbholz M, Metz I, Brück W, Stadelmann C, Merkler D, Gass A, Milenkovic V, Bartenstein P, Albert NL, Kümpfel T, Kerschensteiner M. 2021. TSPO PET imaging of natalizumab-associated progressive multifocal leukoencephalopathy. Brain 144(9):2683-2695.

McMackin R, Dukic S, Costello E, Pinto-Grau M, McManus L, Broderick M, Chipika R, Iyer PM, Heverin M, Bede P, Muthuraman M, Pender N, Hardiman O, Nasseroleslami B. 2021. Cognitive network hyperactivation and motor cortex decline correlate with ALS prognosis. Neurobiol Aging 104:57-70.

Meinl E, Krumbholz M. 2021. Endogenous soluble receptors sBCMA and sTACI: biomarker, immunoregulator and hurdle for therapy in multiple myeloma. Curr Opin Immunol. 71:117-123.

Mitsdörffer M, Di Liberto G, Dötsch S, Sie C, Wagner I, Pfaller M, Kreutzfeldt M, Fräßle S, Aly L, Knier B, Busch DH, Merkler D, Korn T. 2021. Formation and immunomodulatory function of meningeal B-cell aggregates in progressive CNS autoimmunity. Brain 144(6):1697-1710.

Nikolouli E, Elfaki Y, Herppich S, Schelmbauer C, Delacher M, Falk C, Mufazalov IA, Waisman A, Feuerer M, Huehn J. 2021. Recirculating IL-1R2 + Tregs fine-tune intrathymic Treg development under inflammatory conditions. Cell Mol Immunol. 18(1):182-193.

Ostkamp P, Salmen A, Pignolet B, Görlich D, Andlauer TFM, Schulte-Mecklenbeck A, Gonzalez-Escamilla G, Bucciarelli F, Gennero I, Breuer J, Antony G, Schneider-Hohendorf T, Mykicki N, Bayas A, Then Bergh F, Bittner S, Hartung H-P, Friese MA, Linker RA, Luessi F, Lehmann-Horn K, Mühlau M, Paul F, Stangel M, Tackenberg B, Tumani H, Warnke C, Weber F, Wildemann B, Zettl UK, Ziemann U, Müller-Myhsok B, Kümpfel T, Klotz L, Meuth SG, Zipp F, Hemmer B, Hohlfeld R, Brassat D, Gold R, Gross CC, Lukas C, Groppa S, Loser K, Wiendl H, Schwab N, German Competence Network Multiple Sclerosis (KKNMS) and the BIONAT Network. 2021. Sunlight exposure exerts immunomodulatory effects to reduce multiple sclerosis severity. Proc Natl Acad Sci U S A. 118(1):e2018457118.

Penkert H, Bertrand A, Tiwari V, Breimann S, Müller SA, Jordan PM, Gerl MJ, Klose C, Cantuti-Castelvetri L, Bosch-Queralt M, Levental I, Lichtenthaler SF, Werz O, Simons M. 2021. Proteomic and lipidomic profiling of demyelinating lesions identifies fatty acids as modulators in lesion recovery. Cell Rep. 37(4):109898.

Robinson T, Abdelhak A, Bose T, Meinl E, Otto M, Zettl UK, Dersch R, Tumani H, Rauer S, Huss A. 2020. Cerebrospinal Fluid Biomarkers in Relation to MRZ Reaction Status in Primary Progressive Multiple Sclerosis. Cells 9(12):2543.

Radetz A, Mladenova K, Ciolac D, Gonzalez-Escamilla G, Fleischer V, Ellwardt E, Krämer J, Bittner S, Meuth SG, Muthuraman M°, Groppa S°. 2021. Linking Microstructural Integrity and Motor Cortex Excitability in Multiple Sclerosis. Front Immunol. 12:748357.

Schlüter M, Oswald E, Winklmeier S, Meinl I, Havla J, Eichhorn P, Meinl E, Kümpfel T. 2021. Effects of Natalizumab Therapy on Intrathecal Immunoglobulin G Production Indicate Targeting of Plasmablasts. Neurol Neuroimmunol Neuroinflamm. 8(5):e1030.

Schmaul S, Hanuscheck N, Bittner S. 2021. Astrocytic potassium and calcium channels as integrators of the inflammatory and ischemic CNS microenvironment. Biol Chem. 402(12):1519-1530.

Uchida Y, Gherardini J, Pappelbaum K, Cheret J, Schulte-Mecklenbeck A, Gross CC, Strbo N, Gilhar A, Rossi A, Funk W, Kanekura T, Almeida L, Bertolini M, Paus R. 2021. Resident human dermal gamma 6T-cells operate as stress-sentinels: Lessons from the hair follicle. J Autoimmun. 124:102711.

Uphaus T, Steffen F, Muthuraman M, Ripfel N, Fleischer V, Groppa S, Ruck T, Meuth SG, Puld R, Kleinschnitz C, Ellwardt E, Loos J, Engel S, Zipp F, Bittner S. 2021. NfL predicts relapse-free progression in a longitudinal multiple sclerosis cohort study.EBioMedicine. 72:103590.

Wang Q, Akram H, Muthuraman M, Gonzalez-Escamilla G, Sheth SA, Oxenford S, Yeh FC, Groppa S, Vanegas-Arroyave N, Zrinzo L, Li N, Kühn A, Horn A. 2021. Normative vs. patient-specific brain connectivity in deep brain stimulation. Neuroimage 224:117307.

Wiendl H, Gross CC, Bauer J, Merkler D, Prat A, Liblau R. 2021. Fundamental mechanistic insights from rare but paradigmatic neuroimmunological diseases. Nat Rev Neurol. 17(7):433-447.

2020

Aly L, Havla, J, Lepennetier G, Andlauer TFM, Sie C, Strauß EM, Hoshi MM, Kümpfel T, Hiltensperger M, Mittsdoerffer M, Mühlau M, Zimmer C, Hemmer, B, Korn T°, knier B°. 2020. Inner retinal layer thinning in radiologically isolated syndrome predicts conversion to multiple sclerosis. Eur J Neurol. 27(11):2217-2224. (°= equally contributing)

Arloth J°, Eraslan G°, Andlauer TFM, Martins J, Iurato S, Kühnel B, Waldenberger M, Frank J, Gold R, Hemmer B, Luessi F, Nischwitz S, Paul F, Wiendl H, Gieger C, Heilmann-Heimbach S, Kacprowski T, Laudes M, Meitinger T, Peters A, Rawal R, Strauch K, Lucae S, Müller-Myhsok B, Rietschel M, Theis FJ, Binder EB, Mueller NS. 2020. DeepWAS: Multivariate genotype-phenotype associations by directly integrating regulatory information using deep learning. PLoS Comput Biol. 16(2):e1007616.

Backhaus P, Roll W, Beuker C, Zinnhardt B, Seifert R, Wenning C, Eisenblätter M, Thomas C, Schmidt-Pogoda A, Strunk D, Wagner S, Faust A, Tüttelmann F, Röpke A, Jacobs AH, Stummer W, Wiendl H, Meuth SG, Schäfers M, Grauer O, Minnerup J. 2020. Initial experience with [18F]DPA-714 TSPO-PET to image inflammation in primary angiitis of the central nervous system. Eur J Nucl Med Mol Imaging 47:2131–2141.

Baumann T, Dunkel A, Schmid C, Schmitt S, Hiltensperger M, Lohr K, Laketa V, Donakonda S, Ahting U, Lorenz-Depiereux B, Heil JE, Schredelseker J, Simeoni L, Fecher C, Körber N, Bauer T, Hüser N, Hartmann D, Laschinger M, Eyerich K, Eyerich S, Anton M, Streeter M, Wang T, Schraven B, Spiegel D, Assaad F, Misgeld T, Zischka H, Murray PJ, Heine A, Heikenwälder M, Korn T, Dawid C, Hofmann T, Knolle PA, Höchst B. 2020. Regulatory myeloid cells paralyze T cells through cell-cell transfer of the metabolite methylglyoxal. Nat Immunol. 21(5):555-566.

Bittner S°, Steffen F°, Uphaus T, Muthuraman M, Fleischer V, Salmen A, Luessi F, Berthele A, Klotz L, Meuth SG, Bayas A, Paul F, Hartung HP, Linker R, Heesen C, Stangel M, Wildemann B, Then Bergh F, Tackenberg B, Kuempfel T, Weber F, Zettl UK, Ziemann U, Tumani H, Groppa S, Mühlau M, Lukas C, Hemmer B, Wiendl H, Gold R, Zipp F; KKNMS consortium. 2020. Clinical implications of serum neurofilament in newly diagnosed MS patients: A longitudinal multicentre cohort study. EBioMedicine 56:102807. (°= equally contributing)

Cerina M°, Muthuraman M°, Gallus M, Koirala N, Dik A, Wachsmuth L, Hundehege P, Schiffler P, Tenberge JG, Fleischer V, Gonzalez-Escamilla G, Narayanan V, Krämer J, Faber C, Budde T, Groppa S°, Meuth SG°. Myelination- and immune-mediated MR-based brain network correlates. J Neuroinflammation. 17(1):186. (°= equally contributing, shared first/last authorship)

Cunha MI°, Su M°, Cantuti-Castelvetri L, Müller SA, Schifferer M, Djannatian M, Alexopoulos I, van der Meer F, Winkler A, van Ham TJ, Schmid B, Lichtenthaler SF, Stadelmann C, Simons M. 2020. Pro-inflammatory activation following demyelination is required for myelin clearance and oligodendrogenesis. J Exp Med. 217(5):e20191390.

Duscha A°, Gisevius B°, Hirschberg S°, Yissachar N°, Stangl GI, Eilers E, Bader V, Haase S, Kaisler J, David C, Schneider R, Troisi R, Zent D, Hegelmaier T, Dokalis N, Gerstein S, Del Mare-Roumani S, Amidror S, Staszewski O, Poschmann G, Stühler K, Hirche F, Balogh A, Kempa S, Träger P, Zaiss MM, Holm JB, Massa MG, Nielsen HB, Faissner A, Lukas C, Gatermann SG, Scholz M, Przuntek H, Prinz M, Forslund SK, Winklhofer KF, Müller DN, Linker RA*, Gold R*, Haghikia A*. 2020. Propionic Acid Shapes the Multiple Sclerosis Disease Course by an Immunomodulatory Mechanism. Cell 180(6):1067-1080.e16. (° equally contributing, * shared senior authorship)

Ebering A, Waisman A. 2020. Time to activin on pathogenic T cells. Proc Natl Acad Sci U S A. 117(23):12513-12514.

Ellwardt E, Rolfes L, Klein J, Pape K, Ruck T, Wiendl H, Schroeter M, Zipp F, Meuth SG, Warnke C, Bittner S. 2020. Ocrelizumab initiation in patients with MS: A multicenter observational study. Neurol Neuroimmunol Neuroinflamm. 7(4):e719.

Engel S, Luessi F, Mueller A, Schopf RE, Zipp F, Bittner S. 2020. PPMS onset upon adalimumab treatment extends the spectrum of anti-TNF-α therapy-associated demyelinating disorders. Ther Adv Neurol Disord. 13:1756286419895155.

Engel S, Steffen F, Uphaus T, Scholz-Kreisel P, Zipp F, Bittner S, Luessi F. 2020. Association of intrathecal pleocytosis and IgG synthesis with axonal damage in early MS. Neurol Neuroimmunol Neuroinflamm. 7(3):e679.

Engl C, Tiemann L, Grahl S, Bussas M, Schmidt P, Pongratz V, Berthele A, Beer A, Gaser C, Kirschke JS, Zimmer C, Hemmer B, Mühlau M. 2020. Cognitive impairment in early MS: contribution of white matter lesions, deep grey matter atrophy, and cortical atrophy. J Neurol. 267(8):2307-2318.

Eslami M, Meinl E, Eibel H, Willen L, Donzé O, Distl O, Schneider H, Speiser DE, Tsiantoulas D, Yalkinoglu Ö, Samy E, Schneider P. 2020. BAFF 60-mer, and Differential BAFF 60-mer Dissociating Activities in Human Serum, Cord Blood and Cerebrospinal Fluid. Front Cell Dev Biol. 8:577662.

Faber H°, Kurtoic D°, Krishnamoorthy G, Weber P, Pütz B, Müller-Myhsok B, Weber F°, Andlauer TFM°. 2020. Gene Expression in Spontaneous Experimental Autoimmune Encephalomyelitis Is Linked to Human Multiple Sclerosis Risk Genes. Front Immunol. 11:2165. (°= equally contributing)

Faissner S, Graz F, Reinehr S, Petrikowski L, Haupeltshofer S, Ceylan U, Stute G, Winklmeier S, Pache F, Paul F, Ruprecht K, Meinl E, Dick HB, Gold R, Kleiter I°, Joachim SC°. 2020. Binding patterns and functional properties of human antibodies to AQP4 and MOG on murine optic nerve and retina. J Neuroimmunol. 342:577194.

Fitzner D°, Bader JM, Penkert H, Bergner CG, Su M, Weil MT, Surma MA, Mann M, Klose C, Simons M°. 2020. Cell-Type- and Brain-Region-Resolved Mouse Brain Lipidome. Cell Rep 32(11):108132. (°=shared correspondence)

Fleischer V°, Muthuraman M°, Anwar AR, Gonzalez-Escamilla G, Radetz A, Gracien RM, Bittner S, Luessi F, Meuth SG, Zipp F°, Groppa S°. 2020. Continuous reorganization of cortical information flow in multiple sclerosis: A longitudinal fMRI effective connectivity study. Sci Rep.10(1):806.

Gasperi C, Andlauer T, Keating A, Knier B, Klein AK, Pernpeintner V, Lichtner P, Gold R, Zipp F, Then Bergh F, Stangel M, Tumani H, Wildemann BT, Wiendl H, Bayas A, Kümpfel T, Zettl UK, Linker RA, Ziemann U, Knop M, Warnke C, Friese MA, Paul F, Tackenberg B, Berthele A, Hemmer B. Genetic determinants of the humoral immune response in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm. 7(5):e827.

Gerdes LA°, Janoschka C°, Eveslage M, Mannig B, Wirth T, Schulte-Mecklenbeck A, Lauks S, Glau L, Gross CC, Tolosa E, Flierl-Hecht A, Ertl-Wagner B, Barkhof F, Meuth SG, Kümpfel T, Wiendl H°, Hohlfeld R°, Klotz L°. 2020. Immune signatures of prodromal multiple sclerosis in monozygotic twins. Proc Natl Acad Sci U S A 117(35):21546-21556.

Gold R, Montalban X, Haghikia A. 2020. Multiple sclerosis and nutrition: back to the future? Ther Adv Neurol Disord. 13:1756286420936165.

Gödel C, Kunkel B, Kashani A, Lassmann H, Arumugam M, Krishnamoorthy G. 2020. Perturbation of gut microbiota decreases susceptibility but does not modulate ongoing autoimmune neurological disease. J Neuroinflammation 17(1):79.

Gonzalez-Escamilla G, Ciolac D, De Santis S, Radetz A, Fleischer V, Droby A, Roebroeck A, Meuth SG, Muthuraman M°, Groppa S°. 2020. Gray matter network reorganization in multiple sclerosis from 7-Tesla and 3-Tesla MRI data. Ann Clin Transl Neurol. (4):543-553.

Gross CC°, Pawlitzki M°, Schulte-Mecklenbeck A, Rolfes L, Ruck T, Hundehege P, Wiendl H, Herty M°, Meuth SG°. 2020. Generation of a Model to Predict Differentiation and Migration of Lymphocyte Subsets under Homeostatic and CNS Autoinflammatory Conditions. Int J Mol Sci. 21(6). pii: E2046.

Herrmann A°, Cerina M°, Bittner S, Meuth SG°, Budde T°. 2020. Intracellular fluoride influences TASK mediated currents in human T cells. J Immunol Methods 487:112875.(°= equally contributing, shared first/last authorship)

Heß K, Starost L, Kieran NW, Thomas C, Vincenten MCJ, Antel J, Martino G, Huitinga I, Healy L, Kuhlmann T. 2020. Lesion stage-dependent causes for impaired remyelination in MS. Acta Neuropathol. 140(3):359-375.

Huang X, Gänzle M, Loponen J, Schuppan D. 2020. Reply to Comment on Sourdough Fermentation Degrades Wheat Alpha-Amylase/Trypsin Inhibitor (ATI) and Reduces Pro-Inflammatory Activity. Foods 9(10):E1405.

Inan B, Gocmen R, Vural A, Colpak AI, Meinl E, Karabudak R, Tuncer A. 2020. Myelin oligodendrocyte glycoprotein antibody associated central nervous system demyelinating disease: a tertiary center experience from Turkey. Mult Scler Relat Disord. 44:102376.

Lehmann-Horn K°, Irani SR°, Wang S, Palanichamy A, Jahn S, Greenfield AL, Dandekar R, Lepennetier G, Michael S, Gelfand JM, Geschwind MD, Wilson MR, Zamvil SS, von Büdingen HC. 2020 Intrathecal B-cell activation in LGI1 antibody encephalitis. Neurol Neuroimmunol Neuroinflamm. 7(2): e669.

Lichtenthaler SF, Meinl E. 2020. To cut or not to cut: New rules for proteolytic shedding of membrane proteins. J Biol Chem. 295(35):12353-12354.

Liu J, Mori M, Zimmermann H, Brandt A, Havla J, Tanaka S, Sugimoto K, Oji S, Uzawa A, Asseyer S, Cooper G, Jarius S, Bellmann-Strobl J, Ruprecht K, Siebert N, Masuda H, Uchida T, Ohtani R, Nomura K, Meinl E, Kuempfel T, Paul F, Kuwabara S. 2020. Anti-MOG antibody–associated disorders: differences in clinical profiles and prognosis in Japan and Germany.J Neurol Neurosurg Psychiatrydoi: 10.1136/jnnp-2020-324422.

Loos J, Pfeuffer S, Pape K, Ruck T, Luessi F, Spreer A, Zipp F, Meuth SG, Bittner S. 2020. MOG encephalomyelitis: distinct clinical, MRI and CSF features in patients with longitudinal extensive transverse myelitis as first clinical presentation. J Neurol. 267(6):1632-1642.

Lünemann JD°, Ruck T, Muraro PA, Bar-Or A, Wiendl H°. 2020. Immune reconstitution therapies: concepts for durable remission in multiple sclerosis. Nat Rev Neurol 16(1):56-62. (° equally contributing)

Mader S, Kümpfel T, Meinl E. 2020. Novel insights into pathophysiology and therapeutic possibilities reveal further differences between AQP4-IgG- and MOG-IgG-associated diseases. Curr Opin Neurol. 33(3):362-371.

Meyer Zu Hörste G, Gross CC, Klotz L, Schwab N, Wiendl H. 2020. Next-Generation Neuroimmunology: New Technologies to Understand Central Nervous System Autoimmunity. Trends Immunol. 41(4):341-354.

Mohebiany AN, Ramphal NS, Karram K, Di Liberto G, Novkovic T, Klein M, Marini F, Kreutzfeldt M, Härtner F, Lacher SM, Bopp T, Mittmann T, Merkler D, Waisman A. 2020. Microglial A20 Protects the Brain from CD8 T-Cell-Mediated Immunopathology. Cell Rep. 30(5):1585-1597.

Mozafari S, Starost L, Manot-Saillet B, Garcia-Diaz B, Xu YKT, Roussel D, Levy MJF, Ottoboni L, Kim KP, Schöler HR, Kennedy TE, Antel JP, Martino G, Angulo MC, Kuhlmann T, Baron-Van Evercooren A. 2020. Multiple sclerosis iPS-derived oligodendroglia conserve their properties to functionally interact with axons and glia in vivo. Sci Adv. 6(49):eabc6983.

Muthuraman M, Bange M, Groppa S. 2020. Advanced technologies for detecting tremor in Parkinson’s disease. Clin Neurophysiol. 131(1):241-242.

Muthuraman M°, Fleischer V°, Kroth J°, Ciolac D, Radetz A, Koirala N, Gonzalez-Escamilla G, Wiendl H, Meuth SG, Zipp F°, Groppa S°. 2020. Covarying patterns of white matter lesions and cortical atrophy predict progression in early MS. Neurol Neuroimmunol Neuroinflamm.7(3). pii: e681.

Pape K, Steffen F, Zipp F, Bittner S. 2020. Supplementary medication in multiple sclerosis: Real-world experience and potential interference with neurofilament light chain measurement. Mult Scler J Exp Transl Clin. 6(3):2055217320936318.

Pickert G, Wirtz S, Matzner J, Ashfaq-Khan M, Heck R, Rosigkeit S, Thies D, Surabattula R, Ehmann D, Wehkamp J, Aslam M, He G, Weigert A, Foerster F, Klotz L, Frick J-S, Becker C, Bockamp E, Schuppan D. 2020. Wheat Consumption Aggravates Colitis in Mice via Amylase Trypsin Inhibitormediated. Dysbiosis. Gastroenterology159(1):257-272.e17.

Pinteaux E, Abdulaal WH, Mufazalov IA, Humphreys NE, Simonsen-Jackson M, Francis S, Müller W, Waisman A. Cell-specific conditional deletion of interleukin-1 (IL-1) ligands and its receptors: a new toolbox to study the role of IL-1 in health and disease. J Mol Med (Berl). 98(7):923-930.

Radetz A, Koirala N, Krämer J, Johnen A, Fleischer V, Gonzalez-Escamilla G, Cerina M, Muthuraman M°, Meuth SG°, Groppa S°. 2020. Gray matter integrity predicts white matter network reorganization in multiple sclerosis. Hum Brain Mapp. 41(4):917-927.

Samus M, Li YT, Sorokin L, Rottner K, Vestweber D. 2020. Actin-binding protein cortactin promotes pathogenesis of experimental autoimmune encephalomyelitis by supporting leukocyte infiltration into the central nervous system. J Neurosci. 40(7):1389-1404.

Schafflick D°, Xu CA°, Hartlehnert M°, Cole M, Schulte-Mecklenbeck A, Lautwein T, Wolbert J, Heming M, Meuth SG, Kuhlmann T, Gross CC, Wiendl H, Yosef N°, Meyer Zu Horste G° . 2020. Integrated single cell analysis of blood and cerebrospinal fluid leukocytes in multiple sclerosis. Nat Commun. 11(1):247.

Snaidero N, Schifferer M, Mezydlo A, Zalc B, Kerschensteiner M°, Misgeld T°. 2020. Myelin replacement triggered by single-cell demyelination in mouse cortex. Nat Commun. 11(1):4901.(°= equally contributing)

Starost L, Lindner M, Herold M, Xu YKT, Drexler HCA, Heß K, Ehrlich M, Ottoboni L, Ruffini F, Stehling M, Röpke A, Thomas C, Schöler HR, Antel J, Winkler J, Martino G, Klotz L, Kuhlmann T. 2020. Extrinsic immune cell-derived, but not intrinsic oligodendroglial factors contribute to oligodendroglial differentiation block in multiple sclerosis. Acta Neuropathol. 140(5):715-736.

Tinkhauser G, Torrecillos F, Pogosyan A, Mostofi A, Bange M, Fischer P, Tan H, Hasegawa H, Glaser M, Muthuraman M, Groppa S, Ashkan K, Pereira EA, Brown P. 2020. The cumulative effect of transient synchrony states on motor performance in Parkinson’s disease. J Neurosci. 40(7):1571-1580.

Verdu EF, Schuppan D. 2020. The enemy within the gut: bacterial pathogens in celiac autoimmunity. Nat Struct Mol Biol 27(1):5-7.

Wolbert J°, Li X°, Heming M, Mausberg AK, Akkermann D, Frydrychowicz C, Fledrich R, Groeneweg L, Schulz C, Stettner M, Alonso Gonzalez N, Wiendl H, Stassart R°, Meyer Zu Hörste G°. 2020. Redefining the heterogeneity of peripheral nerve cells in health and autoimmunity. Proc Natl Acad Sci U S A. 117(17):9466-9476.

Zhang X, Wang Y, Song J, Gerwien H, Chuquisana O, Chashchina A, Denz C, Sorokin L. 2020. The endothelial basement membrane acts as a checkpoint for entry of pathogenic T cells into the brain. J Exp Med. 17(7):e20191339.

2019

Albrecht S°, Korr S°, Nowack L°, Narayanan V, Starost L, Stortz F, Araúzo-Bravo MJ, Meuth SG, Kuhlmann T, Hundehege P. 2019. The K2P -channel TASK1 affects Oligodendroglial differentiation but not myelin restoration. Glia 67(5):870-883. (°= equally contributing)

Beltran E°, Nguyen XH°, Queriault C, Barateau L, Dauvilliers Y, Dornmair K*, Liblau RS*. 2019. Shared T cell receptor chains in blood memory CD4(+) T cells of narcolepsy type 1 patients. J Autoimmun 100:1-6. (°= equally contributing, *= shared last autors)

Beltran E*, Gerdes LA*, Hansen J, Flierl-Hecht A, Krebs S, Blum H, Ertl-Wagner B, Barkhof F, Kümpfel T, Hohlfeld R, Dornmair K. 2019. Early adaptive immune activation detected in monozygotic twins with prodromal multiple sclerosis. J Clin Invest 129(11):4758-4768. (*= shared first autors)

Birkner K°, Loos J°, Gollan R, Steffen F, Wasser B, Ruck T, Meuth SG, Zipp F, Bittner S. 2019. Neuronal ICAM-5 Plays a Neuroprotective Role in Progressive Neurodegeneration. Front Neurol. 10:205. (°= equally contributing)

Birkner K, Wasser B, Ruck T, Thalman C, Luchtman D, Pape K, Schmaul S, Bitar L, Krämer-Albers EM, Stroh A, Meuth SG, Zipp F, Bittner S. 2019. T β1-integrin- and KV1.3 channel-dependent signaling stimulates glutamate release from Th17 cells. J Clin Invest. 130(2):715-732.

Blankenbach K, Schwab N, Hofner B, Adams O, Keller-Stanislawski B, Warnke C. Natalizumab-associated progressive multifocal leukoencephalopathy in Germany. Neurology 92(19):e2232-e2239.

Breuer J, Loser K, Mykicki N, Wiendl H, Schwab N. 2019. Does the environment influence multiple sclerosis pathogenesis via UVB light and/or induction of vitamin D? J Neuroimmunol. 329:1-8.

Breuer J, Schneider-Hohendorf T, Ostkamp P, Herich S, Rakhade S, Antonijevic I, Klotz L, Wiendl H, Schwab N. 2019. VLA-2 blockade in vivo by vatelizumab induces CD4+FoxP3+ regulatory T cells. International Immunology 31(6):407-12.

Chanoumidou K, Mozafari S, Baron-Van Evercooren A, Kuhlmann T. 2019. Stem cell derived oligodendrocytes to study myelin diseases. Glia. 68(4):705-720.

Ciolac, Luessi F, Gonzalez-Escamilla G, Koirala N, Riedel C, Fleischer V, Bittner S, Krämer J, Meuth SG, Muthuraman M, Groppa S. 2019. Selective Brain Network and Cellular Responses Upon Dimethyl Fumarate Immunomodulation in Multiple Sclerosis. Front Immunol 10:1779.

Engel S°, Friedrich M°, Muthuraman M, Steffen F, Poplawski A, Groppa S, Bittner S, Zipp F, Luessi F. 2019. Intrathecal B-cell accumulation and axonal damage distinguish MRI-based benign from ag-gressive onset in MS. Neurol Neuroimmunol Neuroinflamm 6(5). pii: e595. (°= equally contributing)

Fecher C, Trovò L, Müller SA, Snaidero N, Wettmarshausen J, Heink S, Ortiz O, Wagner I, Kühn R, Hartmann J, Karl RM, Konnerth A, Korn T, Wurst W, Merkler D, Lichtenthaler SF, Perocchi F, Misgeld T. 2019. Cell-type-specific profiling of brain mitochondria reveals functional and molecular diversity. Nat Neurosci 22(10):1731-1742.

Garg G, Muschaweckh A, Moreno H, Vasanthakumar A, Floess S, Lepennetier G, Oellinger R, Zhan Y, Regen T, Hiltensperger M, Peter C, Aly L, Knier B, Palam LR, Kapur R, Kaplan MH, Waisman A, Rad R, Schotta G, Huehn J, Kallies A, Korn T. 2019. Blimp1 Prevents Methylation of Foxp3 and Loss of Regulatory T Cell Identity at Sites of Inflammation. Cell reports 26:1854-1868.

Gross CC, Meyer C, Bhatia U, Yshii L, Kleffner I, Bauer J, Tröscher AR, Schulte-Mecklenbeck A, Herich S, Schneider-Hohendorf T, Plate H, Kuhlmann T, Schwaninger M, Brück W, Pawlitzki M, Laplaud DA, Loussouarn D, Parratt J, Barnett M, Buckland ME, Hardy TA, Reddel SW, Ringelstein M, Dörr J, Wildemann B, Kraemer M, Lassmann H, Höftberger R, Beltrán E, Dornmair K, Schwab N, Klotz L, Meuth SG, Martin-Blondel G, Wiendl H, Liblau R. 2019. CD8+ T cell-mediated endotheliopathy is a targetable mechanism of neuro-inflammation in Susac Syndrome. Nat Commun.10(1):5779.

Harnisch K, Teuber-Hanselmann S, Macha N, Mairinger F, Fritsche L, Soub D, Meinl E, Junker A. 2019. Myelination in Multiple Sclerosis Lesions Is Associated with Regulation of Bone Morphogenetic Protein 4 and Its Antagonist Noggin. Int J Mol Sci 20(1). pii: E154.

Herich S, Schneider-Hohendorf T, Rohlmann A, Khaleghi Ghadiri M, Schulte-Mecklenbeck A, Zondler L, Janoschka C, Ostkamp P, Richter J, Breuer J, Dimitrov S, Rammensee HG, Grauer OM, Klotz L, Gross CC, Stummer W, Missler M, Zarbock A, Vestweber D, Wiendl H, Schwab N. Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis. Brain.142(11):3411-3427.

Hirschberg S°, Gisevius B°, Duscha A, Haghikia A. 2019. Implications of Diet and The Gut Microbiome in Neuroinflammatory and Neurodegenerative Diseases. Int J Mol Sci 20 (12): E3109. (°= equally contributing)

Hoch-Kraft P, Trotter J, Gonsior C. 2019. Missing in Action: Dysfunctional RNA Metabolism in Oligodendroglial Cells as a Contributor to Neurodegenerative Diseases? Neurochem Res 45: 566–579.

Klein A, Selter RC, Hapfelmeier A, Berthele A, Müller-Myhsok B, Pongratz V, Gasperi C, Zimmer C, Mühlau M, Hemmer B. 2019. CSF parameters associated with early MRI activity in patients with MS. Neurol Neuroimmunol Neuroinflamm 6(4):e573.

Klotz L, Eschborn M, Lindner M, Liebmann M, Herold M, Janoschka C, Torres Garrido B2, Schulte-Mecklenbeck A2, Gross CC, Breuer J, Hundehege P, Posevitz V, Pignolet B, Nebel G, Glander S, Freise N, Austermann J, Wirth T, Campbell GR7, Schneider-Hohendorf T, Eveslage M, Brassat D, Schwab N, Loser K, Roth J, Busch KB, Stoll M, Mahad DJ, Meuth SG, Turner T, Bar-Or A, Wiendl H. 2019. Teriflunomide treatment for multiple sclerosis modulates T cell mitochondrial respiration with affinity-dependent effects. Sci Transl Med 11(490). pii: eaao5563.

Klotz L, Havla J, Schwab N, Hohlfeld R, Barnett M, Reddel S, Wiendl H. 2019. Risks and risk management in modern multiple sclerosis immunotherapeutic treatment. Ther Adv Neurol Disord 12:1756286419836571.

Konjevic Sabolek M, Held K, Beltrán E, Niedl AG, Meinl E, Hohlfeld R, Lassmann H, Dornmair K. 2019. Communication of CD8+ T cells with mononuclear phagocytes in multiple sclerosis. Ann Clin Transl Neurol 6(7):1151-1164.

Korn T, Muschaweckh A. 2019. Stability and Maintenance of Foxp3+ Treg Cells in Non-lymphoid Microenvironments. Front Immunol 10:2634.

Kramer J, Bruck W, Zipp F, Cerina M, Groppa S, Meuth SG. 2020. Imaging in mice and men: Pathophysiological insights into multiple sclerosis from. Prog Neurobiol 182:101663.

Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth SG, Groppa S. 2019. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Mult Scler 25(3):338-343.

Lloyd AF, Davies CL, Holloway RK, Labrak Y, Ireland G, Carradori D, Dillenburg A, Borger E, Soong D, Richardson JC, Kuhlmann T, Williams A, Pollard JW, des Rieux A, Priller J, Miron VE. 2019. Central nervous system regeneration is driven by microglia necroptosis and repopulation. Nat Neurosci 22(7):1046-1052.

Lünemann JD, Ruck T, Muraro PA, Bar Or A, Wiendl H. 2019. Immune reconstitution therapies: concepts for durable remission in multiple sclerosis.Nat Rev Neurol. doi: 10.1038/s41582-019-0268-z.

Marti Fernandez I, Macrini C, Krumbholz M, Hensbergen PJ, Hipgrave Ederveen AL, Winklmeier S, Vural A, Kurne A, Jenne D, Kamp F, Gerdes LA, Hohlfeld R, Wuhrer M, Kümpfel T, Meinl E. 2019. The Glycosylation Site of Myelin Oligodendrocyte Glycoprotein Affects Autoantibody Recognition in a Large Proportion of Patients. J Front Immunol 10:1189.

Mues M, Krishnamoorthy G. 2019. BReDi mouse: A novel transgenic mouse strain to track and deplete B cells. Eur J Immunol 49(3):500-503.

Oertel FC, Outteryck O, Knier B, Zimmermann H, Borisow N, Bellmann-Strobl J, Blaschek A, Jarius S, Reindl M, Ruprecht K, Meinl E, Hohlfeld R, Paul F, Brandt AU, Kümpfel T, Havla J. 2019. Optical coherence tomography in myelin-oligodendrocyte-glycoprotein antibody-seropositive patients: a longitudinal study. J Neuroinflammation 16(1):154.

Pape K, Tamouza R, Leboyer M, Zipp F. 2019. Immunoneuropsychiatry – novel perspectives on brain disorders. Nat Rev Neurol 15: 317–328.

Rolfes L, Pawlitzki M, Pfeuffer S, Thomas C, Schmidt-Chanasit J, Gross CC, Schulte-Mecklenbeck A, Wiendl H, Meuth SG, M Grauer O, Ruck T. 2019. Fulminant MS Reactivation Following Combined Fingolimod Cessation and Yellow Fever Vaccination. Int J Mol Sci 20(23).

Ruck T, Schulte-Mecklenbeck A, Pfeuffer S, Heming M, Klotz L, Windhagen S, Kleinschnitz C, Gross CC, Wiendl H, Meuth SG. 2019. Pretreatment anti-thyroid autoantibodies indicate increased risk for thyroid autoimmunity secondary to alemtuzumab: A prospective cohort study. EBioMedicine 46:381-386.

Scheu S, Ali S, Mann-Nüttel R, Richter L, Arolt V, Dannlowski U, Kuhlmann T, Klotz L, Alferink J. 2019. Interferon β-Mediated Protective Functions of Microglia in Central Nervous System Autoimmunity. Int J Mol Sci 20(1). pii: E190.

Schlüter M, Oswald E, Winklmeier S, Meinl I, Havla J, Eichhorn P, Meinl E, Kümpfel T. 2021. Effects of Natalizumab Therapy on Intrathecal Immunoglobulin G Production Indicate Targeting of Plasmablasts. Neurol Neuroimmunol Neuroinflamm. 8(5):e1030.

Schmidt P, Pongratz V, Küster P, Meier D, Wuerfel J, Lukas C, Bellenberg B, Zipp F, Groppa S, Sämann PG, Weber F, Gaser C, Franke T, Bussas M, Kirschke J, Zimmer C, Hemmer B, Mühlau M. 2019. Automated segmentation of changes in FLAIR-hyperintense white matter lesions in multiple sclerosis on serial magnetic resonance imaging. Neuroimage Clin 23:101849.

Schulte-Mecklenbeck A°, Kleffner I°, Beuker C°, Wirth T, Hartwig M, Schmidt-Pogoda A, Klotz L, Hansen W, Wiendl H, Meuth SG, Gross CC, Minnerup J°. 2019. Immunophenotyping of cerebrospinal fluid cells in ischemic stroke. Eur J Neurol 26(6):919-926.

Sie C, Perez LG, Kreutzfeldt M, Potthast M, Ohnmacht C, Merkler D, Huber S, Krug A, Korn T. 2019. Dendritic Cell Accumulation in the Gut and Central Nervous System Is Differentially Dependent on α4 Integrins. J Immunol 203(6):1417-1427.

Souren NY, Gerdes LA, Lutsik P, Gasparoni G, Beltrán E, Salhab A, Kümpfel T, Weichenhan D, Plass C, Hohlfeld R, Walter J. 2019. DNA methylation signatures of monozygotic twins clinically discordant for multiple sclerosis. Nat Commun 10(1):2094.

Stadelmann C, Timmler S, Barrantes-Freer A, Simons M. 2019.Myelin in the Central Nervous System: Structure, Function, and Pathology. Physiol Rev 99(3):1381-1431

Stettner M°, Gross CC°, Mausberg AK, Pul R, Junker A, Baba HA, Schulte-Mecklenbeck A, Wiendl H, Kleinschnitz C°, Meuth SG.° 2019. A fatal case of daclizumab-induced liver failure in a patient with MS. Neurol Neuroimmunol Neuroinflamm e539.

Stork L, Brück W, von Gottberg P, Pulkowski U, Kirsten F, Glatzel M, Rauer S, Scheibe F, Radbruch H, Hammer E, Stürner KH, Kaulen B, Heesen C, Hoffmann F, Brock S, Pawlitzki M, Bopp T, Metz I. 2019. Severe meningo-/encephalitis after daclizumab therapy for multiple sclerosis. Mult Scler 25(12):1618-1632.

Tang Y°, Reissig S°, Glasmacher E, Regen T, Wanke F, Nikolaev A, Gerlach K, Popp V, Karram K, Fantini MC, Schattenberg JM, Galle PR, Neurath MF, Weigmann B, Kurschus FC, Hövelmeyer N, Waisman A. 2019. A lternative Splice Forms of CYLD Mediate Ubiquitination of SMAD7 to Prevent TGFB Signaling and Promote Colitis. Gastroenterology 156(3):692-707. (°=equally contributing)

Tangherlini G, Kalinin DV, Schepmann D, Che T, Mykicki N, Ständer S, Loser K, Wünsch B. 2019. Development of novel quinoxaline-based kappa-opioid receptor (KOR) agonists for the treatment of neuroinflammation. J Med Chem. 62(2):893-907.

Tanti GK, Srivastava R, Kalluri SR, Nowak C, Hemmer B. 2019. Isolation, Culture and Functional Characterization of Glia and Endothelial Cells From Adult Pig Brain. Front Cell Neurosci. 13:333.

Thaler FS, Thaller AL, Biljecki M, Schuh E, Winklmeier S, Mahler CF, Gerhards R, Völk S, Schnorfeil F, Subklewe M, Hohlfeld R, Kümpfel T, Meinl E. 2019. Abundant glutamic acid decarboxylase (GAD)-reactive B cells in gad-antibody-associated neurological disorders. Ann Neurol 85(3):448-454.

Timilshina M, You Z, Lacher SM, Acharya S, Jiang L, Kang Y, Kim JA, Chang HW, Kim KJ, Park B, Song JH, Ko HJ, Park YY, Ma MJ, Nepal MR, Jeong TC, Chung Y, Waisman A, Chang JH. 2019. Activation of Mevalonate Pathway via LKB1 Is Essential for Stability of Treg Cells. Cell Rep 27(10):2948-2961.e7.

Timmler S, Simons M. 2019. Grey matter myelination. Glia 67(11):2063-2070. Review

Trotter J, Mittmann T. 2019. Diversity in the Oligodendrocyte Lineage: Current Evidence. Neuron 101(3):356-357.

Uphaus T, Bittner S, Gröschel S, Steffen F, Muthuraman M, Wasser K, Weber-Krüger M, Zipp F, Wächter R°, Gröschel K°. 2019. Neurofilament light chain levels as a predictive marker for long-term outcome after ischemic stroke. Stroke 50(11): 3077-3084. (°=equally contributing)

Vaquie A, Sauvain A, Duman M, Nocera G, Egger B, Meyenhofer F, Falquet L, Bartesaghi L, Chrast R, Lamy CM, Bang S, Lee SR, Jeon NL, Ruff S, Jacob C. 2019. Injured Axons Instruct Schwann Cells to Build Constricting Actin Spheres to Accelerate Axonal Disintegration. Cell Rep 27 (11):3152-3166 e3157.

Waisman A, Ebering A. 2019. Unraveling the T-B tangle in anti-CD20 multiple sclerosis therapy. Proc Natl Acad Sci U S A 116(51):25376-25377.

Wiendl H, Carraro M, Comi G, Izquierdo G, Kim HJ, Sharrack B, Tornatore C, Daizadeh N, Chung L, Jacobs AK, Hogan RJ, Wychowski LV, Wijmeersch B, CARE-MS I, CARE-MS II, and CAMMS03409 Investigators. 2019. Lymphocyte pharmacodynamics are not associated with autoimmunity or efficacy after alemtuzumab. Neurol Neuroimmunol Neuroinflamm 7(1):e635.

Winklmeier S, Schlüter M, Spadaro M, Thaler FS, Vural A, Gerhards R, Macrini C, Mader S, Kurne A, Inan B, Karabudak R, Özbay FG, Esendagli G, Hohlfeld R, Kümpfel T, Meinl E. Identification of circulating MOG-specific B cells in patients with MOG antibodies. Neurol Neuroimmunol Neuroinflamm 6(6):625.

Witte ME, Schumacher AM, Mahler CF, Bewersdorf JP, Lehmitz J, Scheiter A, Sánchez P, Williams PR, Griesbeck O, Naumann R, Misgeld T, Kerschensteiner M. 2019. Calcium Influx through Plasma-Membrane Nanoruptures Drives Axon Degeneration in a Model of Multiple Sclerosis. Neuron 101(4):615-624.e5.

2018

Hundehege P, Fernandez-Orth J, Römer P, Ruck T, Müntefering T, Eichler S, Cerina M, Epping L, Albrecht S, Menke AF, Birkner K, Göbel K, Budde T, Zipp F, Wiendl H, Gorji A, Bittner S, Meuth SG. 2018.  Targeting Voltage-Dependent Calcium Channels with Pregabalin Exerts a Direct Neuroprotective Effect in an Animal Model of Multiple Sclerosis. Neurosignals 26(1):77-93.

Ruck T, Pfeuffer S, Schulte-Mecklenbeck A, Gross CC, Lindner M, Metze D, Ehrchen J, Sondermann W, Pul R, Kleinschnitz C, Wiendl H, Meuth SG, Klotz L. 2018.  Vitiligo after alemtuzumab treatment: Secondary autoimmunity is not all about B cells. Neurology 91(24):e2233-e2237.

Strunk D, Schulte-Mecklenbeck A, Golombeck KS, Meyer Zu Hörste G, Melzer N, Beuker C, Schmidt A, Wiendl H, Meuth SG, Gross CC, Minnerup J. 2018. Immune cell profiling in the cerebrospinal fluid of patients with primary angiitis of the central nervous system reflects the heterogeneity of the disease. J Neuroimmunol 321:109-116.

Ellwardt E°, Pramanik G°, Luchtman D, Novkovic T, Rosales Jubal E, Vogt J, Arnoux I, Vogelaar CF, Mandal S, Schmalz M, Barger Z, Ruiz de Azua I, Kuhlmann T, Lutz B, Mittmann T, Bittner S, Zipp F§, Stroh A§. 2018. Maladaptive cortical hyperactivity upon recovery from experimental autoimmune encephalomyelitis. Nat Neurosci 21:1392-1403. °equally contributing, §equally contributing and corresponding

International Multiple Sclerosis Genetics Consortium. 2018. Low-Frequency and Rare-Coding Variation Contributes to Multiple Sclerosis Risk. Cell. 175(6):1679-1687.

Louveau A, Herz J, Alme MN, Salvador AF, Dong MQ, Viar KE, Herod SG, Knopp J, Setliff JC, Lupi AL, Da Mesquita S, Frost EL, Gaultier A, Harris TH, Cao R, Hu S, Lukens JR, Smirnov I, Overall CC, Oliver G, Kipnis J. 2018. CNS lymphatic drainage and neuroinflammation are regulated by meningeal lymphatic vasculature. Nat Neurosci 21(10):1380-1391.

Janakiraman M, Krishnamoorthy G. 2018. Emerging Role of Diet and Microbiota Interactions in Neuroinflammation. Front Immunol 9:2067.

Häusler D, Häusser-Kinzel S, Feldmann L, Torke S, Lepennetier G, Bernard CCA, Zamvil SS, Brück W, Lehmann-Horn K, Weber MS. 2018. Functional characterization of reappearing B cells after anti-CD20 treatment of CNS autoimmune disease. Proc Natl Acad Sci U S A 115(39):9773-9778.

Narayanan V, Cerina M, Göbel K, Meuth P, Herrmann AM, Fernandez-Orth J, Stangel M, Gudi V, Skripuletz T, Daldrup T, Lesting J, Schiffler P, Wiendl H, Seidenbecher T, Meuth SG, Budde T, Pape HC. 2018. Impairment of frequency-specific responses associated with altered electrical activity patterns in auditory thalamus following focal and general demyelination. Exp Neurol 309:54-66.

Liebmann M, Hucke S, Koch K, Eschborn M, Ghelman J, Chasan AI, Glander S, Schädlich M, Kuhlencord M, Daber NM, Eveslage M, Beyer M, Dietrich M, Albrecht P, Stoll M, Busch KB, Wiendl H, Roth J, Kuhlmann T, Klotz L. 2018. Nur77 serves as a molecular brake of the metabolic switch during T cell activation to restrict autoimmunity. Proc Natl Acad Sci U S A 115(34):E8017-E8026.

Wanke F, Tang Y, Gronke K, Klebow S, Moos S, Hauptmann J, Shanmugavadivu A, Regen T, Mufazalov IA, Gabriel LA, Reißig S, Diefenbach A, Kurschus FC, Waisman A. 2018. Expression of IL-17F is associated with non-pathogenic Th17 cells. J Mol Med (Berl) 96(8):819-829.

Spadaro M, Winklmeier S, Beltrán E, Macrini C, Höftberger R, Schuh E, Thaler FS, Gerdes LA, Laurent S, Gerhards R, Brändle S, Dornmair K, Breithaupt C, Krumbholz M, Moser M, Kirshnamoorthy G, Kamp F, Jenne D, Hohlfeld R, Kümpfel T, Lassmann H, Kawakami N, Meinl E. 2018. Pathogenicity of human antibodies against myelin oligodendrocyte glycoprotein. Ann Neurol 84(2): 315-328.

Nayak T, Trotter J, Sakry D. 2018. The Intracellular Cleavage Product of the NG2 Proteoglycan Modulates Translation and Cell-Cycle Kinetics via Effects on mTORC1/FMRP Signaling. Front Cell Neurosci 12:231.

Meinl E, Thaler FS, Lichtenthaler SF. 2018. Shedding of BAFF/APRIL Receptors Controls B Cells. Trends Immunol 39(9):673-676.

Luessi F°, Engel S°, Spreer A, Bittner S, Zipp F. 2018.  GFAPα IgG-associated encephalitis upon daclizumab treatment of MS. Neurol Neuroimmunol Neuroinflamm 5(5):e481. °= equally contributing

Lohmann L, Janoschka C, Schulte-Mecklenbeck A, Klinsing S, Kirstein L, Hanning U, Wirth T, Schneider-Hohendorf T, Schwab N, Gross CC, Eveslage M, Meuth SG, Wiendl H, Klotz L. 2018. Immune Cell Profiling During Switching from Natalizumab to Fingolimod Reveals Differential Effects on Systemic Immune-Regulatory Networks and on Trafficking of Non-T Cell Populations into the Cerebrospinal Fluid-Results from the ToFingo Successor Study. Front Immunol 9:1560.

Locatelli G, Theodorou D, Kendirli A, Jordão MJC, Staszewski O, Phulphagar K, Cantuti-Castelvetri L, Dagkalis A, Bessis A, Simons M, Meissner F, Prinz M, Kerschensteiner M. 2018. Mononuclear phagocytes locally specify and adapt their phenotype in a multiple sclerosis model. Nat Neurosci 21(9):1196-1208.

Lindner M, Klotz L, Wiendl H. 2018. Mechanisms underlying lesion development and lesion distribution in CNS autoimmunity. J Neurochem 146(2):122-132.

Buehler U°, Schulenburg K°, Yurugi H°, Šolman M, Abankwa D, Ulges A, Tenzer S, Bopp T, Thiede B, Zipp F§, Rajalingam K§. 2018. Targeting Prohibitins at the cell surface prevents Th17-mediated autoimmunity. EMBO J 37(16).°equally contributing, §equally contributing and corresponding

Breuer J, Korpos E, Hannocks MJ, Schneider-Hohendorf T, Song J, Zondler L, Herich S, Flanagan K, Korn T, Zarbock A, Kuhlmann T, Sorokin L, Wiendl H, Schwab N. Blockade of MCAM/CD146 impedes CNS infiltration of T cells over the choroid plexus. J Neuroinflammation 15(1):236.

Berer K, Martinez I, Walker A, Kunkel B, Schmitt-Kopplin P, Walter J, Krishnamoorthy G. 2018.  Dietary non-fermentable fiber prevents autoimmune neurological disease by changing gut metabolic and immune status. Scientific reports 8: 10431.

Kular L, Liu Y, Ruhrmann S, Zheleznyakova G, Marabita F, Gomez-Cabrero D, James T, Ewing E, Lindén M, Górnikiewicz B, Aeinehband S, Stridh P, Link J, Andlauer TFM, Gasperi C, Wiendl H, Zipp F, Gold R, Tackenberg B, Weber F, Hemmer B, Strauch K, Heilmann-Heimbach S, Rawal R, Schminke U, Schmidt CO, Kacprowski T, Franke A, Laudes M, Dilthey AT, Celius EG, Søndergaard HB, Tegnér J, Harbo HF, Oturai AB, Olafsson S, Eggertsson HP, Halldorsson BV, Hjaltason H, Olafsson E, Jonsdottir I, Stefansson K, Olsson T, Piehl F, Ekström TJ, Kockum I, Feinberg AP, Jagodic M. 2018. DNA methylation as a mediator of HLA-DRB1*15:01 and a protective variant in multiple sclerosis. Nat Commun 9(1):2397.

Hümmert MW, Alvermann S, Gingele S, Gross CC, Wiendl H, Mirenska A, Hennig C, Stangel M. 2018. Immunophenotyping of cerebrospinal fluid cells by Chipcytometry. J Neuroinflammation 15(1):160.

Hoch-Kraft P, White R, Tenzer S, Krämer-Albers EM, Trotter J, Gonsior C. 2018. Dual role of the RNA helicase DDX5 in post-transcriptional regulation of myelin basic protein in oligodendrocytes. J Cell Sci 131(9): pii: jcs204750.

Cerina M, Narayanan V, Delank A, Meuth P, Graebenitz S, Göbel K, Herrmann AM, Albrecht S, Daldrup T, Seidenbecher T, Gorji A, Kuhlmann T, Wiendl H, Kleinschnitz C, Speckmann EJ, Pape HC, Meuth SG, Budde T. 2018.  Protective potential of dimethyl fumarate in a mouse model of thalamocortical demyelination. Brain Struct Funct. 223(7):3091-3106.

Müller K, Schnatz A, Schillner M, Woertge S, Müller C, von Graevenitz I, Waisman A, van Minnen J, Vogelaar CF. 2018. A predominantly glial origin of axonal ribosomes after nerve injury. Glia 66(8):1591-1610.

Garbers C, Heink S, Korn T, Rose-John S. 2018. Interleukin-6: designing specific therapeutics for a complex cytokine. Nat Rev Drug Discov 17(6):395-412.

Muthuraman M°, Raethjen J°, Koirala N, Anwar AR, Mideksa KG, Elble R, Groppa S°, Deuschl G°. 2018. Cerebello-cortical network fingerprints differ between essential, Parkinson’s and mimicked tremors. Brain 141(6):1770-1781. (° = equally contributing)

Schmidt A°, Marabita F, Kiani NA, Gross CC, Johansson HJ, Éliás S, Rautio S, Eriksson M, Fernandes SJ, Silberberg G, Ullah U, Bhatia U, Lähdesmäki H, Lehtiö J, Gomez-Cabrero D, Wiendl H, Lahesmaa R° Tegnér J°. 2018. Time-resolved transcriptome and proteome landscape of human regulatory T cell (Treg) differentiation reveals novel regulators of FOXP3. BMC Biology 16:47 (°= equally contributing)

De Santis S, Bastiani M, Droby A, Kolber P, Zipp F, Pracht E, Stoecker T, Groppa S, Roebroeck A. 2018. Characterizing Microstructural Tissue Properties in Multiple Sclerosis with Diffusion MRI at 7 T and 3 T: The Impact of the Experimental Design. Neuroscience 403:17-26.

Zimmermann HG, Knier B, Oberwahrenbrock T, Behrens J, Pfuhl C, Aly L, Kaminski M, Hoshi MM, Specovius S, Giess RM, Scheel M, Mühlau M, Bellmann-Strobl J, Ruprecht K, Hemmer B, Korn T, Paul F, Brandt AU. 2018. Association of Retinal Ganglion Cell Layer Thickness With Future Disease Activity in Patients With Clinically Isolated Syndrome. JAMA Neurol 75(9):1071-1079.

Ellwardt E, Ellwardt L, Bittner S, Zipp F. 2018. Monitoring B-cell repopulation after depletion therapy in neurologic patients. Neurol Neuroimmunol Neuroinflamm 25;5(4):e463.

Kawakami N. 2018. Intravital Imaging of T Cells Within the Spinal Cord. Methods Mol Biol1763:119-127.

Weider M, Starost L, Groll K, Küspert M, Sock E, Wedel M, Fröb F, Schmitt C, Baroti T, Hartwig AC, Hillgärtner S, Piefke S, Fadler T, Ehrlich M, Ehlert C, Stehling M, Albrecht S, Jabali A, Schöler HR, Winkler J, Kuhlmann T, Wegner M. 2018. Nfat/calcineurin signaling promotes oligodendrocyte differentiation and myelination by transcription factor network tuning. Nat Commun 9(1):899.

Fleischer V, Friedrich M, Rezk A, Bühler U, Witsch E, Uphaus T, Bittner S, Groppa S, Tackenberg B, Bar-Or A, Zipp F, Luessi F. 2018. Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS. Mult Scler 24(5):632-641.

Schneider-Hohendorf T, Görlich D, Savola P, Kelkka T, Mustjoki S, Gross CC, Owens GC, Klotz L, Dornmair K, Wiendl H, Schwab N. 2018. Sex bias in MHC I-associated shaping of the adaptive immune system. Proc Natl Acad Sci U S A 115(9):2168-2173.

Vogelaar CF°, Mandal S°, Lerch S°, Birkner K, Birkenstock J, Bühler U, Schnatz A, Raine CS, Bittner S, Vogt J, Kipnis J, Nitsch R, Zipp F. 2018. Fast direct neuronal signaling via the IL-4 receptor as therapeutic target in neuroinflammation. Sci Transl Med 10(430) (°=equally contributing)

Larochelle C°, Uphaus T°, Broux B, Gowing E, Paterka M, Michel L, Dudvarski Stankovic N, Bicker F, Lemaître F, Prat A°, Schmidt MHH°, Zipp F°. 2018. EGFL7 reduces CNS inflammation in mouse. Nat Commun 9: 819. (°=equally contributing)

Graetz C, Groppa S, Zipp F, Siller N. 2018. Preservation of neuronal function as measured by clinical and MRI endpoints in relapsing-remitting multiple sclerosis: how effective are current treatment strategies? Expert Rev Neurother 18:3, 203-219.

Ullah U, Andrabi SBA, Tripathi SK, Dirasanthi O, Kanduri K, Rautio S, Gross CC, Lehtimki S, Bala K, Tuomisto J, Bhatia U, Chakroborty D, Elo LL, Lähdesmäki H, Wiendl H, Rasool O, Lahesmaa R. 2018. Transcriptional Repressor HIC1 Contributes to Suppressive Function of Human Induced Regulatory T Cells. Cell Reports 22(8):2094-2106.

Siller N, Kuhle J, Muthuraman M, Barro C, Uphaus T, Groppa S, Kappos L, Zipp F, Bittner S. 2018. Serum neurofilament light chain is a biomarker of acute and chronic neuronal damage in early multiple sclerosis. Mult Scler 25(5):678-686.

Belikan P, Bühler U, Wolf C, Pramanik GK, Gollan R, Zipp F, Siffrin V. 2018. CCR7 on CD4+ T Cells Plays a Crucial Role in the Induction of Experimental Autoimmune Encephalomyelitis. J Immunol 200(8):2554-2562. 

Feucht N, Maier M, Lepennetier G, Pettenkofer M, Wetzlmair C, Daltrozzo T, Scherm P, Zimmer C, Hoshi MM, Hemmer B, Korn T, Knier B. 2018. Optical coherence tomography angiography indicates associations of the retinal vascular network and disease activity in multiple sclerosis. Mult Scler 25(2):224-234.

Kieser T, Santschi N, Nowack L, Kehr G, Kuhlmann T, Albrecht S, Gilmour R. 2018. Single Site Fluorination of the GM4 Ganglioside Epitope Upregulates Oligodendrocyte Differentiation. ACS Chem Neurosci 9(5):1159-1165.

Cantuti-Castelvetri L°, Fitzner D°, Bosch-Queralt M, Weil MT, Su M, Sen P, Ruhwedel T, Mitkovski M, Trendelenburg G, Lütjohann D, Möbius W, Simons M. 2018. Defective cholesterol clearance limits remyelination in the aged central nervous system. Science 359(6376):684-688. (°= equally contributing)

Gelderblom M, Gallizioli M, Ludewig P, Thom V, Arunachalam P, Rissiek B, Bernreuther C, Glatzel M, Korn T, Arumugam TV, Sedlacik J, Gerloff C, Tolosa E, Planas AM, Magnus T. 2018. IL-23 (Interleukin-23)-Producing Conventional Dendritic Cells Control the Detrimental IL-17 (Interleukin-17) Response in Stroke. Stroke 49(1):155-164.

Kroth J, Ciolac D, Fleischer V, Koirala N, Krämer J, Muthuraman M, Luessi F, Bittner S, Gonzalez-Escamilla G, Zipp F, Meuth SG, Groppa S. 2018. Increased cerebrospinal fluid albumin and immunoglobulin A fractions forecast cortical atrophy and longitudinal functional deterioration in relapsing-remitting multiple sclerosis. Mult Scler 25(3):338-343.

2017

Fard MK, Meer Fvd, Sánchez P, Cantuti-Castelvetri L, Mandad S, Jäkel S, Fornasiero ES, Schmitt S, Ehrlich M, Starost L, Kuhlmann T, Sergiou C, Schultz V, Wrzos C, Brück W, Urlaub H, Dimou L, Stadelmann C, Simons M. 2017. BCAS1 expression defines a population of early myelinating oligodendrocytes in multiple sclerosis lesions. Sci Transl Med 9(419).

Yshii LM, Hohlfeld R, Liblau RS. 2017. Inflammatory CNS disease caused by immune checkpoint inhibitors: status and perspectives. Nat Rev Neurol 13(12):755-763.

Fleischer V, Radetz A, Ciolac D, Muthuraman M, Gonzalez-Escamilla G, Zipp F, Groppa S. 2017. Graph Theoretical Framework of Brain Networks in Multiple Sclerosis: A Review of Concepts. Neuroscience 403:35-53

Hannocks MJ, Zhang X, Gerwien H, Chashchina A, Burmeister M, Korpos E, Song J, Sorokin L. 2017.  The gelatinases, MMP-2 and MMP-9, as fine tuners of neuroinflammatory processes. Matrix Biol 75-76:102-113.

Malviya M, Barman S, Golombeck KS, Planagumà J, Mannara F, Strutz-Seebohm N, Wrzos C, Demir F, Baksmeier C, Steckel J, Falk KK, Gross CC, Kovac S, Bönte K, Johnen A, Wandinger KP, Martín-García E, Becker AJ, Elger CE, Klöcker N, Wiendl H, Meuth SG, Hartung HP, Seebohm G, Leypoldt F, Maldonado R, Stadelmann C, Dalmau J, Melzer N, Goebels N. NMDAR encephalitis: passive transfer from man to mouse by a recombinant antibody. Ann Clin Transl Neurol 4(11):768-783.

Stangel M, Kuhlmann T, Matthews PM, Kilpatrick TJ. 2017. Achievements and obstacles of remyelinating therapies in multiple sclerosis. Nat Rev Neurol 13(12):742-754.

Prajeeth CK, Kronisch J, Khorooshi R, Knier B, Toft-Hansen H, Gudi V, Floess S, Huehn J, Owens T, Korn T, Stangel M. 2017. Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties. J Neuroinflammation 14(1):204.

Breuer J, Herich S, Schneider-Hohendorf T, Chasan AI, Wettschureck N, Gross CC, Loser K, Zarbock A, Roth J, Klotz L, Wiendl H, Schwab N. 2017. Dual action by fumaric acid esters synergistically reduces adhesion to human endothelium. Mult Scler

Lehmann-Horn K, Kinzel S, Weber M. 2017. Deciphering the Role of B Cells in Multiple Sclerosis-Towards Specific Targeting of Pathogenic Function. Int J Mol Sci 18(10): E2048.

Burg N, Bittner S, Ellwardt E. 2017. Role of the epigenetic factor Sirt7 in neuroinflammation and neurogenesis. Neurosci Res. 131:1-9.

Birkner K, Wasser B, Loos J, Plotnikov A, Seger R, Zipp F, Witsch E°, Bittner S°. 2017. The Role of ERK Signaling in Experimental Autoimmune Encephalomyelitis. Int J Mol Sci 18(9): 1990 (°= equally contributing)

Wiendl H. 2017. Cladribine – an old newcomer for pulsed immune reconstitution in MS. Nat Rev Neurol13 (10): 573–574.

Berer K, Gerdes LA, Cekanaviciute E, Jia X, Xiao L, Xia Z, Liu C, Klotz L, Stauffer U, Baranzini SE, Kümpfel T, Hohlfeld R, Krishnamoorthy G, Wekerle H. 2017. Gut microbiota from multiple sclerosis patients enables spontaneous autoimmune encephalomyelitis in mice. Proc Natl Acad Sci U S A 114(40):10719-10724.

Schwab N, Schneider-Hohendorf T, Hoyt T, Gross CC, Meuth SG, Klotz L, Foley JF, Wiendl H. 2017. Anti-JCV serology during natalizumab treatment: Review and meta-analysis of 17 independent patient cohorts analyzing anti-John Cunningham polyoma virus sero-conversion rates under natalizumab treatment and differences between technical and biological sero-converters. Mult Scler 24(5):563-573.

Leist M, Rinné S, Datunashvili M, Aissaoui A, Pape HC, Decher N, Meuth SG, Budde T. 2017. Acetylcholine-dependent upregulation of TASK-1 channels in thalamic interneurons by a smooth muscle-like signalling pathway. J Physiol 595(17):5875-5893.

Hohlfeld R. 2017. B-cells as therapeutic targets in neuro-inflammatory diseases. Clin Immunol 186:51-53.

Aulova KS, Toporkova LB, Lopatnikova JA, Alshevskaya AA, Sennikov SV, Buneva VN, Budde T, Meuth SG, Popova NA, Orlovskaya IA, Nevinsky GA. 2017. Changes in haematopoietic progenitor colony differentiation and proliferation and the production of different abzymes in EAE mice treated with DNA. J Cell Mol Med 21(12):3795-3809. 

Tischner D, Grimm M, Kaur H, Staudenraus D, Carvalho J, Looso M, Günther S, Wanke F, Moos S, Siller N, Breuer J, Schwab N, Zipp F, Waisman A, Kurschus FC, Offermanns S, Wettschureck N. 2017. Single-cell profiling reveals GPCR heterogeneity and functional patterning during neuroinflammation. JCI Insight 2(15). pii: 95063

Wiendl H, Bourdette D, Ciccarelli O. 2017. Can immune reprogramming with alemtuzumab induce permanent remission in multiple sclerosis? Neurology 89(11):1098-1100.

Herz J, Filiano AJ, Smith A, Yogev N, Kipnis J. 2017. Myeloid Cells in the Central Nervous System. Immunity 46(6):943-956.

Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N.2017. Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proc Natl Acad Sci U S A 114(31):E6381-E6389.

Righart R, Schmidt P, Dahnke R, Biberacher V, Beer A, Buck D, Hemmer B, Kirschke JS, Zimmer C, Gaser C, Mühlau M. 2017. Volume versus surface-based cortical thickness measurements: A comparative study with healthy controls and multiple sclerosis patients. PLoS One 12(7):e0179590.

Fleck AK, Schuppan D, Wiendl H, Klotz L. 2017. Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis. Int J Mol Sci 14:18(7).

Schiffler P, Tenberge JG, Wiendl H, Meuth SG. 2017. Cortex Parcellation Associated Whole White Matter Parcellation in Individual Subjects. Front Hum Neurosci 11:352.

Strippel C, Mönig C, Golombeck KS, Dik A, Bönte K, Kovac S, Schulte-Mecklenbeck A, Wiendl H, Meuth SG, Johnen A, Gross CC, Melzer N. 2017. Treating refractory post-herpetic anti-N-methyl-d-aspartate receptor encephalitis with rituximab. Oxf Med Case Reports (7): omx034.

Schwab N, Melzer N, Cutter G, Wiendl H. 2017. Natalizumab-associated PML: Challenges with incidence, resulting risk, and risk stratification. Neurology 88(12):1197-1205.

Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T. 2017. Activation of FXR pathway does not alter glial cell function. J Neuroinflammation 14(1):66.

Mufazalov IA, Kuschmann J, Andruszewski D, Masri J, Gabriel LA, Adams P, Reissig S, Hövelmeyer N, Waisman A. 2017. Balanced Bcl-3 expression in murine CD4+ T cells is required for generation of encephalitogenic Th17 cells. Eur J Immunol 47(8):1335-1341.

Kitic M, Karram K, Israel N, Yogev N, Lacher SM, Tang Y, Yigit H, Bauer J, Wanke F, Knezovic A, Trotter J, Kurschus FC, Waisman A. 2017. NG2 plays a role in neuroinflammation but is not expressed by immune cells. Acta Neuropathol 134(2):325-327.

Lacher SM, Bruttger J, Kalt B, Berthelet J, Rajalingam K, Wörtge S, Waisman A. 2017. HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival. Cell Death Dis 8(5):e2824.

Biberacher V, Schmidt P, Selter RC, Pernpeinter V, Kowarik MC, Knier B, Buck D, Hoshi MM, Korn T, Berthele A, Kirschke JS, Zimmer C, Hemmer B, Mühlau M. 2017. Fatigue in multiple sclerosis: Associations with clinical, MRI and CSF parameters. Mult Scler 24(8):1115-1125.

Bühler U, Fleischer V, Luessi F, Rezk A, Belikan P, Graetz C, Gollan R, Wolf C, Lutz J, Bar-Or A, Siffrin V, Zipp F. 2017. Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment. Mult Scler 23(4):567-576.

Kolber P°, Droby A°, Roebroeck A, Goebel R, Fleischer V, Groppa S°, Zipp F°. 2017. In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis. Mult Scler 23(8):1167-1169. (°= equally contributing)

Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth SG, Zipp F, Groppa S. 2017. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Mult Scler 23(3):432-441.

Fleischer V, Friedrich M, Rezk A, Bühler U, Witsch E, Uphaus T, Bittner S, Groppa S, Tackenberg B, Bar-Or A, Zipp F°, Luessi F°. 2017. Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS. Mult Scler 24(5):632-641. (°= equally contributing)

Knier B, Leppenetier G, Wetzlmair C, Aly L, Hoshi MM, Pernpeintner V, Biberacher V, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T. 2017. Association of Retinal Architecture, Intrathecal Immunity, and Clinical Course in Multiple Sclerosis. JAMA Neurol 74(7):847-856.

Franck S, Paterka M, Birkenstock J, Zipp F, Siffrin V, Witsch E. 2017. Phenotype of Antigen Unexperienced TH Cells in the Inflamed Central Nervous System in Experimental Autoimmune Encephalomyelitis. J Neuroimmune Pharmacol 12(2):305-313.

Schulte-Mecklenbeck A, Bhatia U, Schneider-Hohendorf T, Schwab N, Wiendl H°, Gross CC°. 2017. Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier. J Vis Exp 122.

Schuh E, Musumeci A, Thaler FS, Laurent S, Ellwart JW, Hohlfeld R, Krug A, Meinl E. 2017. Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement. J Immunol 198(8):3081-3088.

Gracien RM, Reitz SC, Wagner M, Mayer C, Volz S, Hof SM, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Klein JC, Deichmann R. 2017. Comparison of two quantitative proton density mapping methods in multiple sclerosis. MAGMA 30(1):75-83.

Schwab N, Schneider-Hohendorf T, Melzer N, Cutter G, Wiendl H. 2017. Natalizumab-associated PML: Challenges with incidence, resulting risk, and risk stratification. Neurology 88(12):1197-1205.

Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M. 2017. Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin. Cell Rep 18(2):314-323.

Vogel AL, Knier B, Lammens K, Kalluri SR, Kuhlmann T, Bennett JL, Korn T. 2017. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol 47(3):458-469.

Korn T, Kallies A. 2017. T cell responses in the central nervous system. Nat Rev Immunol 17(3):179-194.

Hemmer B, Mühlau M. 2017. Multiple sclerosis in 2016: Immune-directed therapies in MS – efficacy and limitations. Nat Rev Neurol 13(2):72-74.

Droby A, Yuen KS, Schänzer A, Spiwoks-Becker I, Acker T, Lienerth B, Zipp F, Deichmann R. 2017. An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms. Magn Reson Med 77(3):1115-1123.

Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S, Waisman A, Kurschus FC. 2017. EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. Cell Rep 18(5):1270-1284.

Lukas D, Yogev N, Kel JM, Regen T, Mufazalov IA, Tang Y, Wanke F, Reizis B, Müller W, Kurschus FC, Prinz M, Kleiter I, Clausen BE, Waisman A. 2017. TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci U S A 114(8):E1480-E1489.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Droby A, Wahl M, Steinmetz H, Groppa S, Deichmann R, Klein JC. 2017. Longitudinal quantitative MRI assessment of cortical damage in multiple sclerosis: A pilot study. J Magn Reson Imaging 46(5):1485-1490.

Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Schöler HR, Baron-Van Evercooren A, Kuhlmann T. 2017. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proc Natl Acad Sci U S A 114(11):E2243-E2252.

Hallmann AL, Araúzo-Bravo MJ, Mavrommatis L, Ehrlich M, Röpke A, Brockhaus J, Missler M, Sterneckert J, Schöler HR, Kuhlmann T, Zaehres H°, Hargus G.° 2017. Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Sci Rep 7:42991. (°= equally contributing)

Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lütke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L. 2017. Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration. Cell Rep 18(5):1256-1269.

Gross CC°, Meyer zu Hörste G°, Schulte-Mecklenbeck A, Klotz L, Meuth SG, Wiendl H.2017. Reply to Liu et al.: Haplotypematters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis. PNAS 114(6):E908-E909. (°= equally contributing)

Herold M, Klotz L. 2017. Repurposing multiple sclerosis drug dimethyl fumarate, a promising fast track candidate for systemic cutaneous T cell lymphoma treatment. Translational Cancer Research 5 (S7).

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C. 2017. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity 46(1):120-132.

Kuhlmann T, Ludwin S, Prat A, Antel J, Brück W, Lassmann H.2017. An updated histological classification system for multiple sclerosis lesions. Acta Neuropathol 46(1):120-132.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. 2017. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol 18(1):74-85.

Waisman A, Lukas D, Clausen BE, Yogev N. 2017. Dendritic cells as gatekeepers of tolerance. Semin Immunopathol 39(2):153-163.

2016

Miske R, Gross CC, Scharf M, Golombeck KS, Hartwig M, Bhatia U, Schulte-Mecklenbeck A, Bönte K, Strippel C, Schöls L, Synofzik M, Lohmann H, Dettmann IM, Deppe M, Mindorf S, Warnecke T, Denno Y, Teegen B, Probst C, Brakopp S, Wandinger KP, Wiendl H, Stöcker W, Meuth SG, Komorowski L, Melzer N. 2016. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. Neurol Neuroimmunol Neuroinflamm 4(1):e307.

Gross CC, Schulte-Mecklenbeck A, Wiendl H, Marcenaro E, Kerlero de Rosbo N, Uccelli A, Laroni A. 2016. Regulatory Functions of Natural Killer Cells in Multiple Sclerosis. Front. Immunol 7:606.

Kuzmanov I, Herrmann AM, Galla HJ, Meuth SG, Wiendl H, Klotz L. 2016. An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction. J Vis Exp (118).

Göbel K, Kraft P, Pankratz S, Gross CC, Korsukewitz C, Kwiecien R, Mesters R, Kehrel B, Wiendl H, Kleinschnitz C, Meuth SG. 2016. Prothrombin and factor X are elevated in multiple sclerosis patients. Ann Neurol 80(6):946-951.

Mufazalov IA, Schelmbauer C, Regen T, Kuschmann J, Wanke F, Gabriel LA, Hauptmann J, Müller W, Pinteaux E, Kurschus FC, Waisman A. 2016. IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells. EMBO J 36(1):102-115.

Wasser B, Pramanik G, Hess M, Klein M, Luessi F, Dornmair K, Bopp T, Zipp F, Witsch E. 2016. Increase of Alternatively Activated Antigen Presenting Cells in Active Experimental Autoimmune Encephalomyelitis. J Neuroimmune Pharmacol 11(4):721-732.

Knier B, Schmidt P, Aly L, Buck D, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T. 2016. Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis. Brain 139 (11): 2855-2863.

Fleischer V, Kolb R, Groppa S, Zipp F, Klose U, Gröger A. 2016. Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging. Radiology 281(2):536-543.

Paterka M°, Voss JO°, Werr J°, Reuter E, Franck S, Leuenberger T, Herz J, Radbruch H, Bopp T, Siffrin V°, Zipp F°. 2016. Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis. J Autoimmun 76:108-114. (°= equally contributing)

Albrecht S, Hagemeier K, Ehrlich M, Kemming C, Trotter J, Kuhlmann T. 2016. Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan. PLoS One 11(10):e0163841.

Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M. 2016. Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun 7:13275.

Gerwien H°, Hermann S°, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer N, Opdenakker G, Wiendl H, Schäfers M°, Sorokin L.° 2016. Imaging Matrix Metalloproteinase Activity in Multiple Sclerosis as a Specific Marker of Leukocyte Penetration of the Blood-Brain Barrier. Sci Transl Med 8(364):364ra152. (°= equally contributing)

Schwab N, Schneider-Hohendorf T, Pignolet B, Spadaro M, Görlich D, Meinl I, Windhagen S, Tackenberg B, Breuer J, Cantó E, Kümpfel T, Hohlfeld R, Siffrin V, Luessi F, Posevitz-Fejfár A, Montalban X, Meuth SG, Zipp F, Gold R, Du Pasquier RA, Kleinschnitz C, Jacobi A, Comabella M, Bertolotto A, Brassat D, Wiendl H. 2016. PML risk stratification using anti-JCV antibody index and L-selectin.. Mult Scler 22(8):1048-60.

Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG°, Loser K.° 2016. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 8(362):362ra146.(°= equally contributing)

Fleischer V, Groger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth SG, Zipp F, Groppa S. 2016. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Mult Scler 23(3):432-441.

Gross CC°, Ahmetspahic D, Ruck T°, Schulte-Mecklenbeck A, Schwarte K, Jörgens S, Scheu S, Windhagen S, Graefe B, Melzer N, Klotz L, Arolt V, Wiendl H, Meuth SG, Alferink J.2016. Alemtuzumab treatment alters circulating innate immune cells in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 3(6):e289.(°= equally contributing)

Klotz L, Kuzmanov I, Hucke S, Groß CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth S, Kuhlmann T, Wiendl H. 2016. B7-H1 shapes T-cell–mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci USA 113(41):E6182-E6191.

Brändle SM°, Obermeier B°, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch W, Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K. 2016. Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proc Natl Acad Sci USA 113(28):7864-9.(°= equally contributing)

Rühl G°, Niedl AG, Patronov A, Siewert K, Pinkert S, Kalemanov M, Friese MA, Attfield KE, Antes, I, Hohlfeld R, Dornmair K. 2016. Molecular mimicry of an anti-myelin HLA class-I restricted T cell receptor. Neurol. Neuroimmunol Neuroinflamm 3(4):e241. (°= equally contributing)

Gerdes LA°, Held K°, Beltrán E°, Berking C, Prinz JC, Junker A, Tietze J, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K°, Hohlfeld R°. 2016. TCTLA-4 as immunological checkpoint in the development of multiple sclerosis. Ann. Neurol 80(2):294-300. (°= equally contributing)

Cerina M, Narayanan V, Göbel K, Bittner S, Ruck T, Meuth P, Herrmann AM, Stangel M, Gudi V, Skripuletz T, Daldrup T, Wiendl H, Seidenbecher T, Ehling P, Kleinschnitz C, Pape HC, Budde T, Meuth SG. 2016 The quality of cortical network function recovery depends on localization and degree of axonal demyelination. Brain Behav Immun 59:103-117.

Gracien RM, Jurcoane A, Wagner M, Reitz SC, Mayer C, Voltz S, Hof SM, Fleischer V, DrobyA, Steinmetz H, Zipp F, Hattingen E, Deichmann R, Klein JC. 2016. The Relationship between Gray Matter Quantitative MRI and Disability in Secondary Progressive Multiple Sclerosis. PLoS One 11(8):e0161036.

Gracien RM, Nürnberger L, Hok P, Hof SM, Reitz SC, Rüb U, Steinmetz H, Hilker-Roggendorf R, Klein JC, Deichmann R, Baudrexel S. 2016. Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years. Eur Radiol 27(4):1568-1576.

Gross CC, Schulte-Mecklenbeck A, Hanning U, Posevitz-Fejfár A, Korsukewitz C, Schwab N, Meuth SG, Wiendl H, Klotz L. 2016. Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets. Mult Scler 23(7):1025-1030.

Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck AK, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L. 2016. The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion. Acta Neuropathol 132(3):413-31.

Gobel K, Pankratz S°, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C°, Meuth SG. 2016. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 7:11626. (°= equally contributing)

Deppe M°, Kramer J°, Tenberge JG, Marinell J, Schwindt W, Deppe K, Groppa S, Wiendl H, Meuth SG. 2016. Early silent microstructural degeneration and atrophy of the thalamocortical network in multiple sclerosis.. Hum Brain Mapp 37(5):1866-79.(°= equally contributing)

Andlauer TF°, Buck D°, Antony G, Bayas A, Bechmann L, Berthele A, Chan A, Gasperi C, Gold R, Graetz C, Haas J, Hecker M, Infante-Duarte C, Knop M, Kümpfel T, Limmroth V, Linker RA, Loleit V, Luessi F, Meuth SG, Mühlau M, Nischwitz S, Paul F, Pütz M, Ruck T, Salmen A, Stangel M, Stellmann JP, Stürner KH, Tackenberg B, Then Bergh F, Tumani H, Warnke C, Weber F, Wiendl H, Wildemann B, Zettl UK, Ziemann U, Zipp F, Arloth J, Weber P, Radivojkov-Blagojevic M, Scheinhardt MO, Dankowski T, Bettecken T, Lichtner P, Czamara D, Carrillo-Roa T, Binder EB, Berger K, Bertram L, Franke A, Gieger C, Herms S, Homuth G, Ising M, Jöckel KH, Kacprowski T, Kloiber S, Laudes M, Lieb W, Lill CM, Lucae S, Meitinger T, Moebus S, Müller-Nurasyid M, Nöthen MM, Petersmann A, Rawal R, Schminke U, Strauch K, Völzke H, Waldenberger M, Wellmann J, Porcu E, Mulas A, Pitzalis M, Sidore C, Zara I, Cucca F, Zoledziewska M, Ziegler A, Hemmer B°, Müller-Myhsok B°. 2016. Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. Sci Adv 2(6):e1501678. (°= equally contributing)

Schuh E, Berer K, Mulazzani M, Feil K, Meinl I, Lahm H, Krane M, Lange R, Pfannes K, Subklewe M, Gürkov R, Bradl M, Hohlfeld R, Kümpfel T, Meinl E, Krumbholz M. 2016. Features of Human CD3+CD20+ T Cells.. J Immunol 197(4):1111-7.

Ulges A*, Witsch E*, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, Luessi F, Stergiou S, Dietzen S, Brühl T-J, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F°, Bopp T°. 2016. Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. PNAS. 113(36):10145-50. (*= shared first authorship, °= equally contributing)

Göbel K, Pankratz S°, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C°, Meuth SG. 2016. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 7:11626. (°= equally contributing)

Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B. 2016. In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol 79(5):794-805.

Gerdes LA*, Held K, Beltran E*, Berking C, Prinz JC, Junker A, Tietze JK, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K, Hohlfeld R. 2016. CTLA-4 as immunological checkpoint in the development of multiple sclerosis. Ann Neurol 80(2):294-300.

Gracien RM, Jurcoane A, Wagner M, Reitz SC, Mayer C, Volz S, Hof SM, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Deichmann R, Klein JC. 2016. Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis. J Magn Reson Imag 44(6):1600-1607.

Reitz SC, Hof SM, Fleischer V, Brodski A, Gröger A, Gracien RM, Droby A, Steinmetz H, Ziemann U, Zipp F, Deichmann R, Klein JC. 2016. Multi-parametric quantitative MRI of normal appearing white matter in Multiple Sclerosis, and the effect of disease activity on T2. Brain Imaging and Behavior 11(3):744-753.

Droby A, Yuen KSL, Schänzer A, Spiwoks-Becker I, Acker T, Lienerth B, Zipp F, Deichmann R. 2016. An improved anatomical MRI technique with suppression of fixative fluid artefacts for the investigation of human post-mortem brain phantoms. Magn Reson Med 77(3):1115-1123.

Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich A, Held K, KonjeviM, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, and Wiendl H. 2016. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. PNAS 113(21):E2973-82.

Larochelle C, Uphaus T, Prat A, Zipp F. 2016. Secondary progression in multiple sclerosis: neuronal exhaustion or distinct pathology? Trends Neurosci 39(5): 325-339.

Ellwardt E, Walsh JT, Kipnis J, Zipp F. 2016. Understanding the Role of T Cells in CNS Homeostasis. Trends Immunol 37(2): 154-65.

Schwab N, Schneider-Hohendorf T, Pignolet B, Breuer J, Gross CC, Gobel K, Brassat D, and Wiendl H. 2016. Therapy with natalizumab is associated with high JCV seroconversion and rising JCV index values. Neurol Neuroimmunol Neuroinflamm 3: e195.

Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, and Zipp F. 2016. Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation. EMBO J 35: 89-101.

Schneider-Hohendorf T, Mohan H, Bien CG, Breuer J, Becker A, Görlich D, Kuhlmann T, Widman G, Herich S, Elpers C, Melzer N, Dornmair K, Kurlemann G, Wiendl H, Schwab N. 2016. CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing. Nat Commun 7:11153.

Muthuraman M, Fleischer V, Kolber P, Luessi F, Zipp F, and Groppa S. 2016. Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS. Front Neurosci 10: 14.

Luchtman D, Gollan R, Ellwardt E, Birkenstock J, Robohm K, Siffrin V, and Zipp F. 2016. In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity. J Neurochem 136: 971-980.

Huang C, Sakry D, Menzel L, Dangel L, Sebastiani A, Kramer T, Karram K, Engelhard K, Trotter J, and Schafer MK. 2016. Lack of NG2 exacerbates neurological outcome and modulates glial responses after traumatic brain injury. Glia 64: 507-523.

Hohlfeld R, Dornmair K, Meinl E, and Wekerle H. 2016. The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research. Lancet Neurol 15: 317-331.

Gross CC, Schulte-Mecklenbeck A, Klinsing S, Posevitz-Fejfar A, Wiendl H, and Klotz L. 2016. Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 3: e183.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Zimmermann H, Droby A, Steinmetz H, Zipp F, Deichmann R, and Klein JC. 2016. Assessment of cortical damage in early multiple sclerosis with quantitative T relaxometry. NMR Biomed 29: 444-450.

Baudrexel S, Reitz SC, Hof S, Gracien RM, Fleischer V, Zimmermann H, Droby A, Klein JC, and Deichmann R. 2016. Quantitative T and proton density mapping with direct calculation of radiofrequency coil transmit and receive profiles from two-point variable flip angle data. NMR Biomed 29(3): 349-360.

Gross CC°, Schulte-Mecklenbeck A°, Rünzi A, Kuhlmann T, Posevitz-Fejfar A, Schwab N, Schneider-Hohendorf T, Herich S, Held K, Konjevic M, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, Wiendl H.2016. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. Proc Natl Acad Sci U S A 113:E2973-2982. (°= equally contributing)

2015

Wuhrer M, Selman MH, McDonnell LA, Kumpfel T, Derfuss T, Khademi M, Olsson T, Hohlfeld R, Meinl E, and Krumbholz M. 2015. Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid. J Neuroinflammation 12: 235.

Schwab N, Schneider-Hohendorf T, and Wiendl H. 2015. Trafficking of lymphocytes into the CNS. Oncotarget 6: 17863-17864.

Schwab N, Schneider-Hohendorf T, Pignolet B, Spadaro M, Gorlich D, Meinl I, Windhagen S, Tackenberg B, Breuer J, Canto E, Kumpfel T, Hohlfeld R, Siffrin V, Luessi F, Posevitz-Fejfar A, Montalban X, Meuth SG, Zipp F, Gold R, Du Pasquier RA, Kleinschnitz C, Jacobi A, Comabella M, Bertolotto A, Brassat D, and Wiendl H. 2015. PML risk stratification using anti-JCV antibody index and L-selectin. Mult Scler 22(8):1048-60.

Maus F, Sakry D, Biname F, Karram K, Rajalingam K, Watts C, Heywood R, Kruger R, Stegmuller J, Werner HB, Nave KA, Kramer-Albers EM, and Trotter J. 2015. The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2. PLoS ONE 10: e0137311.

Kramer J, Meuth SG, Tenberge JG, Schiffler P, Wiendl H, and Deppe M. 2015. Early and Degressive Putamen Atrophy in Multiple Sclerosis. Int J Mol Sci 16: 23195-23209.

Knier B, Berthele A, Buck D, Schmidt P, Zimmer C, Muhlau M, Hemmer B, and Korn T. 2015. Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination. Mult Scler 22(7):893-900.

Hucke S, Wiendl H, and Klotz L. 2015. Implications of dietary salt intake for multiple sclerosis pathogenesis. Mult Scler 22(2):133-9

Hucke S, Eschborn M, Liebmann M, Herold M, Freise N, Engbers A, Ehling P, Meuth SG, Roth J, Kuhlmann T, Wiendl H, and Klotz L. 2015. Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity. J Autoimmun 67:90-101.

Hohlfeld R, and Wekerle H. 2015. [Multiple sclerosis and microbiota. From genome to metagenome?]. Nervenarzt 86: 925-933.

Hohlfeld R, Dornmair K, Meinl E, and Wekerle H. 2015. The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurol 15(2):198-209.

Hoffmann FS, Hofereiter J, Rubsamen H, Melms J, Schwarz S, Faber H, Weber P, Putz B, Loleit V, Weber F, Hohlfeld R, Meinl E, and Krumbholz M. 2015. Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12: 184.

Herold M, Posevitz V, Chudyka D, Hucke S, Gross C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, and Wiendl H. 2015. B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway. J Immunol 195: 3584-3595.

Held K, Beltran E, Moser M, Hohlfeld R, and Dornmair K. 2015. T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis. Hum Immunol 76: 607-614.

Haghikia A, Jorg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thone J, Demir S, Muller DN, Gold R, and Linker RA. 2015. Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. Immunity 43: 817-829.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Zimmermann H, Droby A, Steinmetz H, Zipp F, Deichmann R, and Klein JC. 2015. Changes and variability of proton density and T1 relaxation times in early multiple sclerosis: MRI markers of neuronal damage in the cerebral cortex. Eur Radiol 26(8):2578-86

Gliem M, Klotz L, van Rooijen N, Hartung HP, and Jander S. 2015. Hyperglycemia and PPARgamma Antagonistically Influence Macrophage Polarization and Infarct Healing After Ischemic Stroke. Stroke 46: 2935-2942.

Droby A, Yuen KS, Muthuraman M, Reitz SC, Fleischer V, Klein J, Gracien RM, Ziemann U, Deichmann R, Zipp F, and Groppa S. 2015. Changes in brain functional connectivity patterns are driven by an individual lesion in MS: a resting-state fMRI study. Brain Imaging Behav 10(4):1117-1126

Wiendl H, Elger C, Forstl H, Hartung HP, Oertel W, Reichmann H, and Schwab S. 2015. Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage (“Neuroprotection”). Neurotherapeutics 12: 449-454.

Warnke C, Stettner M, Lehmensiek V, Dehmel T, Mausberg AK, von Geldern G, Gold R, Kumpfel T, Hohlfeld R, Maurer M, Stangel M, Straeten V, Limmroth V, Weber T, Kleinschnitz C, Wattjes MP, Svenningsson A, Olsson T, Hartung HP, Hermsen D, Tumani H, Adams O, and Kieseier BC. 2015. Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF. Mult Scler 21: 1036-1044.

Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Golz G, Rosenberger K, Kammertons T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, and Kipnis J. 2015. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest 125: 699-714.

Waisman A, Liblau R, and Becher B. 2015. Innate and adaptive immune responses in the CNS. The Lancet Neurology 14: 945-955.

Waisman A, Hauptmann J, and Regen T. 2015. The role of IL-17 in CNS diseases. Acta Neuropathol 129: 625-637.

Vestweber D. 2015. Cadherins in tissue architecture and disease. J Mol Med (Berl) 93: 5-11.

Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Bruhl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reissig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, and Bopp T. 2015. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat Immunol 16: 267-275.

Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S, Krumbholz M, Breithaupt C, Hogen T, Straube A, Giese A, Hohlfeld R, Lassmann H, Meinl E, and Kumpfel T. 2015. Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. Ann Clin Transl Neurol 2: 295-301.

Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schafers M, Korner H, Opdenakker G, Hallmann R, and Sorokin L. 2015. Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration. Cell Rep 10: 1040-1054.

Siffrin V, Birkenstock J, Luchtman DW, Gollan R, Baumgart J, Niesner RA, Griesbeck O, and Zipp F. 2015. FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis. J Neurosci Methods 249: 8-15.

Schwab N, Schneider-Hohendorf T, and Wiendl H. 2015. Therapeutic uses of anti-alpha4-integrin (anti-VLA-4) antibodies in multiple sclerosis. Int Immunol 27: 47-53.

Sakry D, and Trotter J. 2015. The role of the NG2 proteoglycan in OPC and CNS network function. Brain Res 1638(Pt B):161-166.

Rumble JM, Huber AK, Krishnamoorthy G, Srinivasan A, Giles DA, Zhang X, Wang L, and Segal BM. 2015. Neutrophil-related factors as biomarkers in EAE and MS. J Exp Med 212: 23-35.

Reuter E, Gollan R, Grohmann N, Paterka M, Salmon H, Birkenstock J, Richers S, Leuenberger T, Brandt AU, Kuhlmann T, Zipp F, and Siffrin V. 2015. Cross-recognition of a myelin peptide by CD8+ T cells in the CNS is not sufficient to promote neuronal damage. J Neurosci 35: 4837-4850.

Reissig S, Hovelmeyer N, Tang Y, Weih D, Nikolaev A, Riemann M, Weih F, and Waisman A. 2015. The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells. Immunol Cell Biol 93: 558-566.

Preisner A, Albrecht S, Cui QL, Hucke S, Ghelman J, Hartmann C, Taketo MM, Antel J, Klotz L, and Kuhlmann T. 2015. Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination. Acta Neuropathol 130: 247-261.

Nemecek A, Zimmermann H, Rubenthaler J, Fleischer V, Paterka M, Luessi F, Muller-Forell W, Zipp F, and Siffrin V. 2015. Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression. Mult Scler 22(4):483-93.

Luessi F, Kraus S, Trinschek B, Lerch S, Ploen R, Paterka M, Roberg T, Poisa-Beiro L, Klotz L, Wiendl H, Bopp T, Jonuleit H, Jolivel V, Zipp F, and Witsch E. 2015. FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis. Mult Scler 21(14):1811-22

Lindner M, Thummler K, Arthur A, Brunner S, Elliott C, McElroy D, Mohan H, Williams A, Edgar JM, Schuh C, Stadelmann C, Barnett SC, Lassmann H, Mucklisch S, Mudaliar M, Schaeren-Wiemers N, Meinl E, and Linington C. 2015. Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9. Brain 138: 1875-1893.

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rubsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, and Meinl E. 2015. gamma-Secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun 6: 7333.

Kurschus FC. 2015. T cell mediated pathogenesis in EAE: Molecular mechanisms. Biomed J 38: 183-193.

Kramer J, Deppe M, Gobel K, Tabelow K, Wiendl H, and Meuth SG. 2015. Recovery of thalamic microstructural damage after Shiga toxin 2-associated hemolytic-uremic syndrome. J Neurol Sci 356: 175-183.

Kowarik MC, Dzieciatkowska M, Wemlinger S, Ritchie AM, Hemmer B, Owens GP, and Bennett JL. 2015. The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations. J Neuroinflammation 12: 19.

Knier B, Rothhammer V, Heink S, Puk O, Graw J, Hemmer B, and Korn T. 2015. Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis. J Autoimmun 56: 34-44.

Hoppmann N, Graetz C, Paterka M, Poisa-Beiro L, Larochelle C, Hasan M, Lill CM, Zipp F, and Siffrin V. 2015. New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis. Brain 138: 902-917.

Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kumpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, and Meinl E. 2015. The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. J Immunol 194: 542-552.

Hemmer B, Kerschensteiner M, and Korn T. 2015. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol 14: 406-419.

Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltran E, Schmidt S, Ruhl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, and Dornmair K. 2015. alphabeta T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm 2: e107.

Hallmann R, Zhang X, Di Russo J, Li L, Song J, Hannocks MJ, and Sorokin L. 2015. The regulation of immune cell trafficking by the extracellular matrix. Curr Opin Cell Biol 36: 54-61.

Grutzke B, Hucke S, Gross CC, Herold MV, Posevitz-Fejfar A, Wildemann BT, Kieseier BC, Dehmel T, Wiendl H, and Klotz L. 2015. Fingolimod treatment promotes regulatory phenotype and function of B cells. Ann Clin Transl Neurol 2: 119-130.

Gobel K, Bittner S, Cerina M, Herrmann AM, Wiendl H, and Meuth SG. 2015. An ex vivo model of an oligodendrocyte-directed T-cell attack in acute brain slices. J Vis Exp.

Ehrlich M, Hallmann AL, Reinhardt P, Arauzo-Bravo MJ, Korr S, Ropke A, Psathaki OE, Ehling P, Meuth SG, Oblak AL, Murrell JR, Ghetti B, Zaehres H, Scholer HR, Sterneckert J, Kuhlmann T, and Hargus G. 2015. Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein. Stem Cell Reports 5: 83-96.

Droby A, Lukas C, Schanzer A, Spiwoks-Becker I, Giorgio A, Gold R, De Stefano N, Kugel H, Deppe M, Wiendl H, Meuth SG, Acker T, Zipp F, and Deichmann R. 2015. A human post-mortem brain model for the standardization of multi-centre MRI studies. Neuroimage 110: 11-21.

Droby A, Fleischer V, Carnini M, Zimmermann H, Siffrin V, Gawehn J, Erb M, Hildebrandt A, Baier B, and Zipp F. 2015. The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients. Neuroimage Clin 8: 110-116.

Deppe M, Tabelow K, Kramer J, Tenberge JG, Schiffler P, Bittner S, Schwindt W, Zipp F, Wiendl H, and Meuth SG. 2015. Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration. Mult Scler 22(1):73-84

Bruttger J, Karram K, Wortge S, Regen T, Marini F, Hoppmann N, Klein M, Blank T, Yona S, Wolf Y, Mack M, Pinteaux E, Muller W, Zipp F, Binder H, Bopp T, Prinz M, Jung S, and Waisman A. 2015. Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. Immunity 43: 92-106.

Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HC, Oliver D, Meuth SG, and Budde T. 2015. Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. J Physiol 593: 127-144.

2014

Luessi F, Kuhlmann T, and Zipp F. 2014. Remyelinating strategies in multiple sclerosis. Expert Rev Neurother 14: 1315-1334.

Warnke C, von Geldern G, Markwerth P, Dehmel T, Hoepner R, Gold R, Pawlita M, Kumpfel T, Maurer M, Stangel M, Wegner F, Hohlfeld R, Straeten V, Limmroth V, Weber T, Hermsen D, Kleinschnitz C, Hartung HP, Wattjes MP, Svenningson A, Major E, Olsson T, Kieseier BC, and Adams O. 2014. Cerebrospinal fluid JC virus antibody index for diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy. Ann Neurol 76: 792-801.

Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, and Rajalingam K. 2014. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J 33: 1784-1801.

Sie C, Korn T, and Mitsdoerffer M. 2014. Th17 cells in central nervous system autoimmunity. Exp Neurol 262 Pt A: 18-27.

Shen P, Roch T, Lampropoulou V, O’Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grutzkau A, Grun JR, Horn K, Kuhl AA, Dorner T, Bar-Or A, Kaufmann SH, Anderton SM, and Fillatreau S. 2014. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature 507: 366-370.

Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross C, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, and Wiendl H. 2014. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. Journal of Clinical Investigation 9: 1833-1846.

Schneider-Hohendorf T, Philipp K, Husstedt IW, Wiendl H, and Schwab N. 2014. Specific loss of cellular L-selectin on CD4(+) T cells is associated with progressive multifocal leukoencephalopathy development during HIV infection. AIDS 28: 793-795.

Schmitt E, Klein M, and Bopp T. 2014. Th9 cells, new players in adaptive immunity. Trends Immunol 35: 61-68.

Schirmer L, Srivastava R, Kalluri SR, Bottinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, and Hemmer B. 2014. Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol 75: 810-828.

Schirmer L, Srivastava R, and Hemmer B. 2014. To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis. Mult Scler 20: 271-279.

Sakry D, Neitz A, Singh J, Frischknecht R, Marongiu D, Biname F, Perera SS, Endres K, Lutz B, Radyushkin K, Trotter J, and Mittmann T. 2014. Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2. PLoS Biol 12: e1001993.

Rothhammer V, Muschaweckh A, Gasteiger G, Petermann F, Heink S, Busch DH, Heikenwalder M, Hemmer B, Drexler I, and Korn T. 2014. alpha4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets. Acta Neuropathol Commun 2: 27.

Posevitz-Fejfar A, and Wiendl H. 2014. The neuroinflammation biobank in the Department of Neurology, University Hospital Muenster, Germany. Biopreserv Biobank 12: 74-75.

Posevitz-Fejfar A, Posevitz V, Gross CC, Bhatia U, Kurth F, Schutte V, Bar-Or A, Meuth SG, and Wiendl H. 2014. Effects of blood transportation on human peripheral mononuclear cell yield, phenotype and function: implications for immune cell biobanking. PLoS One 9: e115920.

Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, Kuhlmann T, Linington C, and Meinl E. 2014. Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathol Commun 2: 168.

Luchtman DW, Ellwardt E, Larochelle C, and Zipp F. 2014. IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments. Cytokine Growth Factor Rev 25: 403-413.

Kraus SH, Luessi F, Trinschek B, Lerch S, Hubo M, Poisa-Beiro L, Paterka M, Jonuleit H, Zipp F, and Jolivel V. 2014. Cladribine exerts an immunomodulatory effect on human and murine dendritic cells. Int Immunopharmacol 18: 347-357.

Korn T. 2014. How do Th17 cells mediate autoimmune inflammation in the central nervous system?. Clinical and Experimental Neuroimmunology 5: 120-131.

Hovelmeyer N, Worns MA, Reissig S, Adams-Quack P, Leclaire J, Hahn M, Wortge S, Nikolaev A, Galle PR, and Waisman A. 2014. Overexpression of Bcl-3 inhibits the development of marginal zone B cells. Eur J Immunol 44: 545-552.

Hoffmann F, and Meinl E. 2014. B cells in multiple sclerosis: good or bad guys?: An article for 28 May 2014 – World MS Day 2014. Eur J Immunol 44: 1247-1250.

Heinen AP, Wanke F, Moos S, Attig S, Luche H, Pal PP, Budisa N, Fehling HJ, Waisman A, and Kurschus FC. 2014. Improved method to retain cytosolic reporter protein fluorescence while staining for nuclear proteins. Cytometry A 85: 621-627.

Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, and Korn T. 2014. IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1. Nat Commun 5: 3770.

Hargus G, Ehrlich M, Arauzo-Bravo MJ, Hemmer K, Hallmann AL, Reinhardt P, Kim KP, Adachi K, Santourlidis S, Ghanjati F, Fauser M, Ossig C, Storch A, Kim JB, Schwamborn JC, Sterneckert J, Scholer HR, Kuhlmann T, and Zaehres H. 2014. Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain. Cell Rep 8: 1697-1703.

Gritsch S, Lu J, Thilemann S, Wortge S, Mobius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, and Kuner R. 2014. Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice. Nat Commun 5: 5472.

Gonsior C, Biname F, Fruhbeis C, Bauer NM, Hoch-Kraft P, Luhmann HJ, Trotter J, and White R. 2014. Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival. PLoS One 9: e89423.

Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, and Ruland J. 2014. Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep 9: 1292-1305.

Deppe M, Marinell J, Kramer J, Duning T, Ruck T, Simon OJ, Zipp F, Wiendl H, and Meuth SG. 2014. Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis. Neuroimage Clin 6: 475-487.

Croxford AL, Karbach S, Kurschus FC, Wortge S, Nikolaev A, Yogev N, Klebow S, Schuler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Munzel T, von Stebut E, and Waisman A. 2014. IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions. J Invest Dermatol 134: 728-735.

Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Kohl J, Offermanns S, Wettschureck N, and Schwaninger M. 2014. Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE. J Clin Invest 124: 2188-2192.

Bittner S, Ruck T, Fernandez-Orth J, and Meuth SG. 2014. TREK-king the blood-brain-barrier. J Neuroimmune Pharmacol 9: 293-301.

Berer K, and Krishnamoorthy G. 2014. Microbial view of central nervous system autoimmunity. FEBS Lett 588: 4207-4213.

Berer K, Boziki M, and Krishnamoorthy G. 2014. Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS One 9: e87876.

Beltran E, Obermeier B, Moser M, Coret F, Simo-Castello M, Bosca I, Perez-Miralles F, Villar LM, Senel M, Tumani H, Hohlfeld R, Casanova B, and Dornmair K. 2014. Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation. Brain 137: 2703-2714.

2013

Zipp F, Gold R, and Wiendl H. 2013. Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies?. JAMA Neurol 70: 1569-1574.

Zayoud M, El Malki K, Frauenknecht K, Trinschek B, Kloos L, Karram K, Wanke F, Georgescu J, Hartwig UF, Sommer C, Jonuleit H, Waisman A, and Kurschus FC. 2013. Subclinical CNS inflammation as response to a myelin antigen in humanized mice. J Neuroimmune Pharmacol 8: 1037-1047.

Wiendl H, and Gross CC. 2013. Modulation of IL-2Ralpha with daclizumab for treatment of multiple sclerosis. Nat Rev Neurol 9: 394-404.

Wekerle H, Berer K, and Krishnamoorthy G. 2013. Remote control-triggering of brain autoimmune disease in the gut. Curr Opin Immunol 25: 683-689.

Stangel M, Fredrikson S, Meinl E, Petzold A, Stuve O, and Tumani H. 2013. The utility of cerebrospinal fluid analysis in patients with multiple sclerosis. Nat Rev Neurol 9: 267-276.

Schwab N, Schneider-Hohendorf T, Posevitz V, Breuer J, Gobel K, Windhagen S, Brochet B, Vermersch P, Lebrun-Frenay C, Posevitz-Fejfar A, Capra R, Imberti L, Straeten V, Haas J, Wildemann B, Havla J, Kumpfel T, Meinl I, Niessen K, Goelz S, Kleinschnitz C, Warnke C, Buck D, Gold R, Kieseier BC, Meuth SG, Foley J, Chan A, Brassat D, and Wiendl H. 2013. L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients. Neurology 81: 865-871.

Romanelli E, Sorbara CD, Nikic I, Dagkalis A, Misgeld T, and Kerschensteiner M. 2013. Cellular, subcellular and functional in vivo labeling of the spinal cord using vital dyes. Nat Protoc 8: 481-490.

Mitsdoerffer M, Kuchroo V, and Korn T. 2013. Immunology of neuromyelitis optica: a T cell-B cell collaboration. Ann N Y Acad Sci 1283: 57-66.

Mayer MC, Breithaupt C, Reindl M, Schanda K, Rostasy K, Berger T, Dale RC, Brilot F, Olsson T, Jenne D, Probstel AK, Dornmair K, Wekerle H, Hohlfeld R, Banwell B, Bar-Or A, and Meinl E. 2013. Distinction and temporal stability of conformational epitopes on myelin oligodendrocyte glycoprotein recognized by patients with different inflammatory central nervous system diseases. J Immunol 191: 3594-3604.

Lurbke A, Hagemeier K, Cui QL, Metz I, Bruck W, Antel J, and Kuhlmann T. 2013. Limited TCF7L2 expression in MS lesions. PLoS One 8: e72822.

Lindner M, Ng JK, Hochmeister S, Meinl E, and Linington C. 2013. Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis. Exp Neurol 247: 259-266.

Liblau RS, Gonzalez-Dunia D, Wiendl H, and Zipp F. 2013. Neurons as targets for T cells in the nervous system. Trends Neurosci 36: 315-324.

Leuenberger T, Paterka M, Reuter E, Herz J, Niesner RA, Radbruch H, Bopp T, Zipp F, and Siffrin V. 2013. The role of CD8+ T cells and their local interaction with CD4+ T cells in myelin oligodendrocyte glycoprotein35-55-induced experimental autoimmune encephalomyelitis. J Immunol 191: 4960-4968.

Lang C, Bradley PM, Jacobi A, Kerschensteiner M, and Bareyre FM. 2013. STAT3 promotes corticospinal remodelling and functional recovery after spinal cord injury. EMBO Rep 14: 931-937.

Jolivel V, Luessi F, Masri J, Kraus SH, Hubo M, Poisa-Beiro L, Klebow S, Paterka M, Yogev N, Tumani H, Furlan R, Siffrin V, Jonuleit H, Zipp F, and Waisman A. 2013. Modulation of dendritic cell properties by laquinimod as a mechanism for modulating multiple sclerosis. Brain 136: 1048-1066.

Hucke S, Wiendl H, Knolle P, and Klotz L. 2013. Nuclear receptor control of myeloid cell responses—implications for CNS autoimmunity. Rheumatology 3: 1-12.

Havla J, Tackenberg B, Hellwig K, Meinl I, Krumbholz M, Seitz F, Eienbroker C, Gold R, Hohlfeld R, Kleiter I, and Kumpfel T. 2013. Fingolimod reduces recurrence of disease activity after natalizumab withdrawal in multiple sclerosis. J Neurol 260: 1382-1387.

Havla J, Berthele A, Kumpfel T, Krumbholz M, Jochim A, Kronsbein H, Ryschkewitsch C, Jensen P, Lippmann K, Hemmer B, Major E, and Hohlfeld R. 2013. Co-occurrence of two cases of progressive multifocal leukoencephalopathy in a natalizumab “infusion group”. Mult Scler 19: 1213-1215.

Gross CC, and Wiendl H. 2013. Dendritic cell vaccination in autoimmune disease. Curr Opin Rheumatol 25: 268-274.

Gobel K, Wedell JH, Herrmann AM, Wachsmuth L, Pankratz S, Bittner S, Budde T, Kleinschnitz C, Faber C, Wiendl H, and Meuth SG. 2013. 4-Aminopyridine ameliorates mobility but not disease course in an animal model of multiple sclerosis. Exp Neurol 248: 62-71.

Cravens PD, Kieseier BC, Hussain R, Herndon E, Arellano B, Ben LH, Timmons BC, Castro-Rojas C, Hartung HP, Hemmer B, Weber MS, Zamvil SS, and Stuve O. 2013. The neonatal CNS is not conducive for encephalitogenic Th1 T cells and B cells during experimental autoimmune encephalomyelitis. J Neuroinflammation 10: 67.

Bittner S, Ruck T, Schuhmann MK, Herrmann AM, Moha ou Maati H, Bobak N, Gobel K, Langhauser F, Stegner D, Ehling P, Borsotto M, Pape HC, Nieswandt B, Kleinschnitz C, Heurteaux C, Galla HJ, Budde T, Wiendl H, and Meuth SG. 2013. Endothelial TWIK-related potassium channel-1 (TREK1) regulates immune-cell trafficking into the CNS. Nat Med 19: 1161-1165.

2012

Krumbholz M, Derfuss T, Hohlfeld R, and Meinl E. 2012. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol 8: 613-623.