Publications

2017

Kyratsous NI, Bauer IJ, Zhang G, Pesic M, Bartholomäus I, Mues M, Fang P, Wörner M, Everts S, Ellwart JW, Watt JM, Potter BVL, Hohlfeld R, Wekerle H, Kawakami N.2017. Visualizing context-dependent calcium signaling in encephalitogenic T cells in vivo by two-photon microscopy. Proc Natl Acad Sci U S A. 114(31):E6381-E6389.

Righart R, Schmidt P, Dahnke R, Biberacher V, Beer A, Buck D, Hemmer B, Kirschke JS, Zimmer C, Gaser C, Mühlau M. 2017. Volume versus surface-based cortical thickness measurements: A comparative study with healthy controls and multiple sclerosis patients. PLoS One. 12(7):e0179590.

Fleck AK, Schuppan D, Wiendl H, Klotz L. 2017. Gut-CNS-Axis as Possibility to Modulate Inflammatory Disease Activity-Implications for Multiple Sclerosis. Int J Mol Sci. 14;18(7).

Schiffler P, Tenberge JG, Wiendl Hand Meuth SG. 2017. Cortex Parcellation Associated Whole White Matter Parcellation in Individual Subjects. Front. Hum. Neurosci. 11:352.

Strippel C, Mönig C, Golombeck KS, Dik A, Bönte K, Kovac S, Schulte-Mecklenbeck A, Wiendl H, Meuth SG, Johnen A, Gross CC, Melzer N. 2017. Treating refractory post-herpetic anti-N-methyl-d-aspartate receptor encephalitis with rituximab. Oxf Med Case Reports (7): omx034.

Schneider-Hohendorf T, Melzer N, Cutter G, Wiendl H. (2017) Natalizumab-associated PML: Challenges with incidence, resulting risk, and risk stratification. Neurology 88(12):1197-1205

Albrecht S, Fleck AK, Kirchberg I, Hucke S, Liebmann M, Klotz L, Kuhlmann T. 2017. Activation of FXR pathway does not alter glial cell function. J Neuroinflammation 14(1):66.

Mufazalov IA, Kuschmann J, Andruszewski D, Masri J, Gabriel LA, Adams P, Reissig S, Hövelmeyer N, Waisman A. 2017. Balanced Bcl-3 expression in murine CD4+ T cells is required for generation of encephalitogenic Th17 cells. Eur J Immunol.

Kitic M, Karram K, Israel N, Yogev N, Lacher SM, Tang Y, Yigit H, Bauer J, Wanke F, Knezovic A, Trotter J, Kurschus FC, Waisman A. 2017. NG2 plays a role in neuroinflammation but is not expressed by immune cells. Acta Neuropathol

Lacher SM, Bruttger J, Kalt B, Berthelet J, Rajalingam K, Wörtge S, Waisman A. 2017. HMG-CoA reductase promotes protein prenylation and therefore is indispensible for T-cell survival. Cell Death Dis 8(5):e2824

Biberacher V, Schmidt P, Selter RC, Pernpeinter V, Kowarik MC, Knier B, Buck D, Hoshi MM, Korn T, Berthele A, Kirschke JS, Zimmer C, Hemmer B, Mühlau M. 2017. Fatigue in multiple sclerosis: Associations with clinical, MRI and CSF parameters. Mult Scler

Bühler U, Fleischer V, Luessi F, Rezk A, Belikan P, Graetz C, Gollan R, Wolf C, Lutz J, Bar-Or A, Siffrin V, Zipp F. 2017. Role of IL-17-producing lymphocytes in severity of multiple sclerosis upon natalizumab treatment. Mult Scler 23(4):567-576

Kolber P°, Droby A°, Roebroeck A, Goebel R, Fleischer V, Groppa S°, Zipp F°. 2017. In-vivo 7T evidence of meningeal inflammation in early multiple sclerosis. Mult Scler 23(8):1167-1169 (°= equally contributing)

Fleischer V, Gröger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth SG, Zipp F, Groppa S. 2017. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Mult Scler23(3):432-441.

Fleischer V, Friedrich M, Rezk A, Bühler U, Witsch E, Uphaus T, Bittner S, Groppa S, Tackenberg B, Bar-Or A, Zipp F°, Luessi F°. 2017. Treatment response to dimethyl fumarate is characterized by disproportionate CD8+ T cell reduction in MS. Mult Scler (°= equally contributing)

Knier B, Leppenetier G, Wetzlmair C, Aly L, Hoshi MM, Pernpeintner V, Biberacher V, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T. 2017. Association of Retinal Architecture, Intrathecal Immunity, and Clinical Course in Multiple Sclerosis. JAMA Neurol

Franck S, Paterka M, Birkenstock J, Zipp F, Siffrin V, Witsch E. 2017. Phenotype of Antigen Unexperienced TH Cells in the Inflamed Central Nervous System in Experimental Autoimmune Encephalomyelitis. J Neuroimmune Pharmacol 12(2):305-313.

Schulte-Mecklenbeck A, Bhatia U, Schneider-Hohendorf T, Schwab N, Wiendl H°, Gross CC°. 2017. Analysis of Lymphocyte Extravasation Using an In Vitro Model of the Human Blood-brain Barrier. J Vis Exp 122.

Schuh E, Musumeci A, Thaler FS, Laurent S, Ellwart JW, Hohlfeld R, Krug A, Meinl E. 2017. Human Plasmacytoid Dendritic Cells Display and Shed B Cell Maturation Antigen upon TLR Engagement. J Immunol 198(8):3081-3088.

Gracien RM, Reitz SC, Wagner M, Mayer C, Volz S, Hof SM, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Klein JC, Deichmann R. 2017. Comparison of two quantitative proton density mapping methods in multiple sclerosis. MAGMA 30(1):75-83.

Schwab N, Schneider-Hohendorf T, Melzer N, Cutter G, Wiendl H. 2017. Natalizumab-associated PML: Challenges with incidence, resulting risk, and risk stratification. Neurology 88(12):1197-1205.

Snaidero N, Velte C, Myllykoski M, Raasakka A, Ignatev A, Werner HB, Erwig MS, Möbius W, Kursula P, Nave KA, Simons M. 2017. Antagonistic Functions of MBP and CNP Establish Cytosolic Channels in CNS Myelin. Cell Rep 18(2):314-323.

Vogel AL, Knier B, Lammens K, Kalluri SR, Kuhlmann T, Bennett JL, Korn T. 2017. Deletional tolerance prevents AQP4-directed autoimmunity in mice. Eur J Immunol 47(3):458-469.

Korn T, Kallies A. 2017. T cell responses in the central nervous system. Nat Rev Immunol 17(3):179-194.

Ingrisch M, Sourbron S, Herberich S, Schneider MJ, Kümpfel T, Hohlfeld R, Reiser MF, Ertl-Wagner B. 2017. Dynamic Contrast-Enhanced Magnetic Resonance Imaging Suggests Normal Perfusion in Normal-Appearing White Matter in Multiple Sclerosis. Invest Radiol 52(3):135-141.

Hemmer B, Mühlau M. 2017. Multiple sclerosis in 2016: Immune-directed therapies in MS – efficacy and limitations. Nat Rev Neurol 13(2):72-74. 

Droby A, Yuen KS, Schänzer A, Spiwoks-Becker I, Acker T, Lienerth B, Zipp F, Deichmann R. 2017. An improved anatomical MRI technique with suppression of fixative fluid artifacts for the investigation of human postmortem brain phantoms. Magn Reson Med 77(3):1115-1123.

Wanke F, Moos S, Croxford AL, Heinen AP, Gräf S, Kalt B, Tischner D, Zhang J, Christen I, Bruttger J, Yogev N, Tang Y, Zayoud M, Israel N, Karram K, Reißig S, Lacher SM, Reichhold C, Mufazalov IA, Ben-Nun A, Kuhlmann T, Wettschureck N, Sailer AW, Rajewsky K, Casola S, Waisman A, Kurschus FC. 2017. EBI2 Is Highly Expressed in Multiple Sclerosis Lesions and Promotes Early CNS Migration of Encephalitogenic CD4 T Cells. Cell Rep 18(5):1270-1284.

Lukas D, Yogev N, Kel JM, Regen T, Mufazalov IA, Tang Y, Wanke F, Reizis B, Müller W, Kurschus FC, Prinz M, Kleiter I, Clausen BE, Waisman A. 2017. TGF-β inhibitor Smad7 regulates dendritic cell-induced autoimmunity. Proc Natl Acad Sci U S A 114(8):E1480-E1489. 

Gracien RM, Reitz SC, Hof SM, Fleischer V, Droby A, Wahl M, Steinmetz H, Groppa S, Deichmann R, Klein JC. 2017. Longitudinal quantitative MRI assessment of cortical damage in multiple sclerosis: A pilot study. J Magn Reson Imaging.

Ehrlich M, Mozafari S, Glatza M, Starost L, Velychko S, Hallmann AL, Cui QL, Schambach A, Kim KP, Bachelin C, Marteyn A, Hargus G, Johnson RM, Antel J, Sterneckert J, Zaehres H, Schöler HR, Baron-Van Evercooren A, Kuhlmann T. 2017. Rapid and efficient generation of oligodendrocytes from human induced pluripotent stem cells using transcription factors. Proc Natl Acad Sci U S A 114(11):E2243-E2252.

Hallmann AL, Araúzo-Bravo MJ, Mavrommatis L, Ehrlich M, Röpke A, Brockhaus J, Missler M, Sterneckert J, Schöler HR, Kuhlmann T, Zaehres H°, Hargus G.° 2017. Astrocyte pathology in a human neural stem cell model of frontotemporal dementia caused by mutant TAU protein. Sci Rep 7:42991. (°= equally contributing)

Paterka M°, Voss JO, Werr J, Reuter E, Franck S, Leuenberger T, Herz J, Radbruch H, Bopp T, Siffrin V, Zipp F°.2017. Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis. J Autoimmun 76:108-114.(°= equally contributing)

Song J, Zhang X, Buscher K, Wang Y, Wang H, Di Russo J, Li L, Lütke-Enking S, Zarbock A, Stadtmann A, Striewski P, Wirth B, Kuzmanov I, Wiendl H, Schulte D, Vestweber D, Sorokin L. 2017. Endothelial Basement Membrane Laminin 511 Contributes to Endothelial Junctional Tightness and Thereby Inhibits Leukocyte Transmigration. Cell Rep 18(5):1256-1269.

Gross CC°, Meyer zu Hörste G°, Schulte-Mecklenbeck A, Klotz L, Meuth SG, Wiendl H.2017. Reply to Liu et al.: Haplotypematters: CD226 polymorphism as a potential trigger for impaired immune regulation in multiple sclerosis. PNAS 114(6):E908-E909. (°= equally contributing)

Herold M, Klotz L. 2017. Repurposing multiple sclerosis drug dimethyl fumarate, a promising fast track candidate for systemic cutaneous T cell lymphoma treatment. Translational Cancer Research 5 (S7).

Miske R, Gross CC, Scharf M, Golombeck KS, Hartwig M, Bhatia U, Schulte-Mecklenbeck A, Bönte K, Strippel C, Schöls L, Synofzik M, Lohmann H, Dettmann IM, Deppe M, Mindorf S, Warnecke T, Denno Y, Teegen B, Probst C, Brakopp S, Wandinger KP, Wiendl H, Stöcker W, Meuth SG, Komorowski L, Melzer N. 2017. Neurochondrin is a neuronal target antigen in autoimmune cerebellar degeneration. Neurol Neuroimmunol Neuroinflamm 4(1):e307.

Druzd D, Matveeva O, Ince L, Harrison U, He W, Schmal C, Herzel H, Tsang AH, Kawakami N, Leliavski A, Uhl O, Yao L, Sander LE, Chen CS, Kraus K, de Juan A, Hergenhan SM, Ehlers M, Koletzko B, Haas R, Solbach W, Oster H, Scheiermann C. 2017. Lymphocyte Circadian Clocks Control Lymph Node Trafficking and Adaptive Immune Responses. Immunity 46(1):120-132.

Kuhlmann T, Ludwin S, Prat A, Antel J, Brück W, Lassmann H.2017. An updated histological classification system for multiple sclerosis lesions. Acta Neuropathol 46(1):120-132.

Heink S, Yogev N, Garbers C, Herwerth M, Aly L, Gasperi C, Husterer V, Croxford AL, Möller-Hackbarth K, Bartsch HS, Sotlar K, Krebs S, Regen T, Blum H, Hemmer B, Misgeld T, Wunderlich TF, Hidalgo J, Oukka M, Rose-John S, Schmidt-Supprian M, Waisman A, Korn T. 2017. Trans-presentation of IL-6 by dendritic cells is required for the priming of pathogenic TH17 cells. Nat Immunol 18(1):74-85.

Waisman A, Lukas D, Clausen BE, Yogev N. 2017. Dendritic cells as gatekeepers of tolerance. Semin Immunopathol 39(2):153-163.

2016

Gross CC, Schulte-Mecklenbeck A, Wiendl H, Marcenaro E, Kerlero de Rosbo N, Uccelli A, Laroni A. 2016. Regulatory Functions of Natural Killer Cells in Multiple Sclerosis. Front. Immunol 7:606. 

Kuzmanov I, Herrmann AM, Galla HJ, Meuth SG, Wiendl H, Klotz L. 2016. An In Vitro Model of the Blood-brain Barrier Using Impedance Spectroscopy: A Focus on T Cell-endothelial Cell Interaction. J Vis Exp (118).

Göbel K, Kraft P, Pankratz S, Gross CC, Korsukewitz C, Kwiecien R, Mesters R, Kehrel B, Wiendl H, Kleinschnitz C, Meuth SG. 2016. Prothrombin and factor X are elevated in multiple sclerosis patients. Ann Neurol 80(6):946-951.

Mufazalov IA, Schelmbauer C, Regen T, Kuschmann J, Wanke F, Gabriel LA, Hauptmann J, Müller W, Pinteaux E, Kurschus FC, Waisman A. 2016. IL-1 signaling is critical for expansion but not generation of autoreactive GM-CSF+ Th17 cells. EMBO J 36(1):102-115.

Wasser B, Pramanik G, Hess M, Klein M, Luessi F, Dornmair K, Bopp T, Zipp F, Witsch E. 2016. Increase of Alternatively Activated Antigen Presenting Cells in Active Experimental Autoimmune Encephalomyelitis. J Neuroimmune Pharmacol 11(4):721-732.

Knier B, Schmidt P, Aly L, Buck D, Berthele A, Mühlau M, Zimmer C, Hemmer B, Korn T. 2016. Retinal inner nuclear layer volume reflects response to immunotherapy in multiple sclerosis. Brain 139 (11): 2855-2863.

Fleischer V, Kolb R, Groppa S, Zipp F, Klose U, Gröger A. 2016. Metabolic Patterns in Chronic Multiple Sclerosis Lesions and Normal-appearing White Matter: Intraindividual Comparison by Using 2D MR Spectroscopic Imaging. Radiology 281(2):536-543.

Paterka M°, Voss JO°, Werr J°, Reuter E, Franck S, Leuenberger T, Herz J, Radbruch H, Bopp T, Siffrin V°, Zipp F°. 2016. Dendritic cells tip the balance towards induction of regulatory T cells upon priming in experimental autoimmune encephalomyelitis. J Autoimmun 76:108-114. (°= equally contributing)

Albrecht S, Hagemeier K, Ehrlich M, Kemming C, Trotter J, Kuhlmann T. 2016. Recovery from Toxic-Induced Demyelination Does Not Require the NG2 Proteoglycan. PLoS One 11(10):e0163841.

Romanelli E, Merkler D, Mezydlo A, Weil MT, Weber MS, Nikić I, Potz S, Meinl E, Matznick FE, Kreutzfeldt M, Ghanem A, Conzelmann KK, Metz I, Brück W, Routh M, Simons M, Bishop D, Misgeld T, Kerschensteiner M. 2016. Myelinosome formation represents an early stage of oligodendrocyte damage in multiple sclerosis and its animal model. Nat Commun 7:13275.

Gerwien H°, Hermann S°, Zhang X, Korpos E, Song J, Kopka K, Faust A, Wenning C, Gross CC, Honold L, Melzer N, Opdenakker G, Wiendl H, Schäfers M°, Sorokin L.° 2016. Imaging Matrix Metalloproteinase Activity in Multiple Sclerosis as a Specific Marker of Leukocyte Penetration of the Blood-Brain Barrier. Sci Transl Med 8(364):364ra152. (°= equally contributing)

Mykicki N, Herrmann AM, Schwab N, Deenen R, Sparwasser T, Limmer A, Wachsmuth L, Klotz L, Köhrer K, Faber C, Wiendl H, Luger TA, Meuth SG°, Loser K.° 2016. Melanocortin-1 receptor activation is neuroprotective in mouse models of neuroinflammatory disease. Sci Transl Med 8(362):362ra146.(°= equally contributing)

Fleischer V, Groger A, Koirala N, Droby A, Muthuraman M, Kolber P, Reuter E, Meuth SG, Zipp F, Groppa S. 2016. Increased structural white and grey matter network connectivity compensates for functional decline in early multiple sclerosis. Mult Scler 23(3):432-441.

Gross CC°, Ahmetspahic D, Ruck T°, Schulte-Mecklenbeck A, Schwarte K, Jörgens S, Scheu S, Windhagen S, Graefe B, Melzer N, Klotz L, Arolt V, Wiendl H, Meuth SG, Alferink J.2016. Alemtuzumab treatment alters circulating innate immune cells in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 3(6):e289. (°= equally contributing)

Klotz L, Kuzmanov I, Hucke S, Groß CC, Posevitz V, Dreykluft A, Schulte-Mecklenbeck A, Janoschka C, Lindner M, Herold M, Schwab N, Ludwig-Portugall I, Kurts C, Meuth S, Kuhlmann T, Wiendl H. 2016. B7-H1 shapes T-cell–mediated brain endothelial cell dysfunction and regional encephalitogenicity in spontaneous CNS autoimmunity. Proc Natl Acad Sci USA 113(41):E6182-E6191.

Brändle SM°, Obermeier B°, Senel M, Bruder J, Mentele R, Khademi M, Olsson T, Tumani H, Kristoferitsch W, Lottspeich F, Wekerle H, Hohlfeld R, Dornmair K. 2016. Distinct oligoclonal band antibodies in multiple sclerosis recognize ubiquitous self-proteins. Proc Natl Acad Sci USA 113(28):7864-9.(°= equally contributing)

Rühl G°, Niedl AG, Patronov A, Siewert K, Pinkert S, Kalemanov M, Friese MA, Attfield KE, Antes, I, Hohlfeld R, Dornmair K. 2016. Molecular mimicry of an anti-myelin HLA class-I restricted T cell receptor. Neurol. Neuroimmunol Neuroinflamm 3(4):e241. (°= equally contributing)

Gerdes LA°, Held K°, Beltrán E°, Berking C, Prinz JC, Junker A, Tietze J, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K°, Hohlfeld R°. 2016. TCTLA-4 as immunological checkpoint in the development of multiple sclerosis. Ann. Neurol 80(2):294-300. (°= equally contributing)

Cerina M, Narayanan V, Göbel K, Bittner S, Ruck T, Meuth P, Herrmann AM, Stangel M, Gudi V, Skripuletz T, Daldrup T, Wiendl H, Seidenbecher T, Ehling P, Kleinschnitz C, Pape HC, Budde T, Meuth SG. 2016 The quality of cortical network function recovery depends on localization and degree of axonal demyelination. Brain Behav Immun 59:103-117.

Gracien RM, Jurcoane A, Wagner M, Reitz SC, Mayer C, Voltz S, Hof SM, Fleischer V, DrobyA, Steinmetz H, Zipp F, Hattingen E, Deichmann R, Klein JC. 2016. The Relationship between Gray Matter Quantitative MRI and Disability in Secondary Progressive Multiple Sclerosis. PLoS One 11(8):e0161036.

Gracien RM, Nürnberger L, Hok P, Hof SM, Reitz SC, Rüb U, Steinmetz H, Hilker-Roggendorf R, Klein JC, Deichmann R, Baudrexel S. 2016. Evaluation of brain ageing: a quantitative longitudinal MRI study over 7 years. Eur Radiol 27(4):1568-1576.

Gross CC, Schulte-Mecklenbeck A, Hanning U, Posevitz-Fejfár A, Korsukewitz C, Schwab N, Meuth SG, Wiendl H, Klotz L. 2016. Distinct pattern of lesion distribution in multiple sclerosis is associated with different circulating T-helper and helper-like innate lymphoid cell subsets. Mult Scler 23(7):1025-1030.

Hucke S, Herold M, Liebmann M, Freise N, Lindner M, Fleck AK, Zenker S, Thiebes S, Fernandez-Orth J, Buck D, Luessi F, Meuth SG, Zipp F, Hemmer B, Engel DR, Roth J, Kuhlmann T, Wiendl H, Klotz L. 2016. The farnesoid-X-receptor in myeloid cells controls CNS autoimmunity in an IL-10-dependent fashion. Acta Neuropathol 132(3):413-31.

Gobel K, Pankratz S°, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C°, Meuth SG. 2016. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 7:11626. (°= equally contributing)

Deppe M°, Kramer J°, Tenberge JG, Marinell J, Schwindt W, Deppe K, Groppa S, Wiendl H, Meuth SG. 2016. Early silent microstructural degeneration and atrophy of the thalamocortical network in multiple sclerosis.. Hum Brain Mapp 37(5):1866-79. (°= equally contributing)

Andlauer TF°, Buck D°, Antony G, Bayas A, Bechmann L, Berthele A, Chan A, Gasperi C, Gold R, Graetz C, Haas J, Hecker M, Infante-Duarte C, Knop M, Kümpfel T, Limmroth V, Linker RA, Loleit V, Luessi F, Meuth SG, Mühlau M, Nischwitz S, Paul F, Pütz M, Ruck T, Salmen A, Stangel M, Stellmann JP, Stürner KH, Tackenberg B, Then Bergh F, Tumani H, Warnke C, Weber F, Wiendl H, Wildemann B, Zettl UK, Ziemann U, Zipp F, Arloth J, Weber P, Radivojkov-Blagojevic M, Scheinhardt MO, Dankowski T, Bettecken T, Lichtner P, Czamara D, Carrillo-Roa T, Binder EB, Berger K, Bertram L, Franke A, Gieger C, Herms S, Homuth G, Ising M, Jöckel KH, Kacprowski T, Kloiber S, Laudes M, Lieb W, Lill CM, Lucae S, Meitinger T, Moebus S, Müller-Nurasyid M, Nöthen MM, Petersmann A, Rawal R, Schminke U, Strauch K, Völzke H, Waldenberger M, Wellmann J, Porcu E, Mulas A, Pitzalis M, Sidore C, Zara I, Cucca F, Zoledziewska M, Ziegler A, Hemmer B°, Müller-Myhsok B°. 2016. Novel multiple sclerosis susceptibility loci implicated in epigenetic regulation. Sci Adv 2(6):e1501678. (°= equally contributing)

Schuh E, Berer K, Mulazzani M, Feil K, Meinl I, Lahm H, Krane M, Lange R, Pfannes K, Subklewe M, Gürkov R, Bradl M, Hohlfeld R, Kümpfel T, Meinl E, Krumbholz M. 2016. Features of Human CD3+CD20+ T Cells.. J Immunol 197(4):1111-7.

Ulges A*, Witsch E*, Pramanik G, Klein M, Birkner K, Bühler U, Wasser B, Luessi F, Stergiou S, Dietzen S, Brühl T-J, Bohn T, Bündgen G, Kunz H, Waisman A, Schild H, Schmitt E, Zipp F°, Bopp T°. 2016. Protein kinase CK2 governs the molecular decision between encephalitogenic TH17 cell and Treg cell development. PNAS. 113(36):10145-50. (*= shared first authorship, °= equally contributing)

Schneider-Hohendorf T°, Mohan H°, Bien CG, Breuer J, Becker A, Görlich D, Kuhlmann T, Widman G, Herich S, Elpers C, Melzer N, Dornmair K, Kurlemann G, Wiendl H, Schwab N. 2016. CD8(+) T-cell pathogenicity in Rasmussen encephalitis elucidated by large-scale T-cell receptor sequencing. Nat Commun. 7:11153. (°= equally contributing)

Göbel K, Pankratz S°, Asaridou CM, Herrmann AM, Bittner S, Merker M, Ruck T, Glumm S, Langhauser F, Kraft P, Krug TF, Breuer J, Herold M, Gross CC, Beckmann D, Korb-Pap A, Schuhmann MK, Kuerten S, Mitroulis I, Ruppert C, Nolte MW, Panousis C, Klotz L, Kehrel B, Korn T, Langer HF, Pap T, Nieswandt B, Wiendl H, Chavakis T, Kleinschnitz C°, Meuth SG. 2016. Blood coagulation factor XII drives adaptive immunity during neuroinflammation via CD87-mediated modulation of dendritic cells. Nat Commun 7:11626. (°= equally contributing)

Herwerth M, Kalluri SR, Srivastava R, Kleele T, Kenet S, Illes Z, Merkler D, Bennett JL, Misgeld T, Hemmer B. 2016. In vivo imaging reveals rapid astrocyte depletion and axon damage in a model of neuromyelitis optica-related pathology. Ann Neurol

Gerdes LA*, Held K, Beltran E*, Berking C, Prinz JC, Junker A, Tietze JK, Ertl-Wagner B, Straube A, Kümpfel T, Dornmair K, Hohlfeld R. 2016. CTLA-4 as immunological checkpoint in the development of multiple sclerosis. Ann Neurol 80(2):294-300.

Gracien RM, Jurcoane A, Wagner M, Reitz SC, Mayer C, Volz S, Hof SM, Fleischer V, Droby A, Steinmetz H, Groppa S, Hattingen E, Deichmann R, Klein JC. 2016. Multimodal quantitative MRI assessment of cortical damage in relapsing-remitting multiple sclerosis. J Magn Reson Imag 44(6):1600-1607.

Reitz SC, Hof SM, Fleischer V, Brodski A, Gröger A, Gracien RM, Droby A, Steinmetz H, Ziemann U, Zipp F, Deichmann R, Klein JC. 2016. Multi-parametric quantitative MRI of normal appearing white matter in Multiple Sclerosis, and the effect of disease activity on T2. Brain Imaging and Behavior 11(3):744-753.

Droby A, Yuen KSL, Schänzer A, Spiwoks-Becker I, Acker T, Lienerth B, Zipp F, Deichmann R. 2016. An improved anatomical MRI technique with suppression of fixative fluid artefacts for the investigation of human post-mortem brain phantoms. Magn Reson Med 77(3):1115-1123.

Gross CC, Schulte-Mecklenbeck A, Rünzi A, Kuhlmann T, Posevitz-Fejfár A, Schwab N, Schneider-Hohendorf T, Herich A, Held K, KonjeviM, Hartwig M, Dornmair K, Hohlfeld R, Ziemssen T, Klotz L, Meuth SG, and Wiendl H. 2016. Impaired NK-mediated regulation of T-cell activity in multiple sclerosis is reconstituted by IL-2 receptor modulation. PNAS 113(21):E2973-82.

Larochelle C, Uphaus T, Prat A, Zipp F. 2016. Secondary progression in multiple sclerosis: neuronal exhaustion or distinct pathology? Trends Neurosci 39(5): 325-339.

Ellwardt E, Walsh JT, Kipnis J, Zipp F. 2016. Understanding the Role of T Cells in CNS Homeostasis. Trends Immunol 37(2): 154-65.

Schwab N, Schneider-Hohendorf T, Pignolet B, Breuer J, Gross CC, Gobel K, Brassat D, and Wiendl H. 2016. Therapy with natalizumab is associated with high JCV seroconversion and rising JCV index values. Neurol Neuroimmunol Neuroinflamm 3: e195.

Paterka M, Siffrin V, Voss JO, Werr J, Hoppmann N, Gollan R, Belikan P, Bruttger J, Birkenstock J, Jung S, Esplugues E, Yogev N, Flavell RA, Bopp T, and Zipp F. 2016. Gatekeeper role of brain antigen-presenting CD11c+ cells in neuroinflammation. EMBO J 35: 89-101.

Muthuraman M, Fleischer V, Kolber P, Luessi F, Zipp F, and Groppa S. 2016. Structural Brain Network Characteristics Can Differentiate CIS from Early RRMS. Front Neurosci 10: 14.

Luchtman D, Gollan R, Ellwardt E, Birkenstock J, Robohm K, Siffrin V, and Zipp F. 2016. In vivo and in vitro effects of multiple sclerosis immunomodulatory therapeutics on glutamatergic excitotoxicity. J Neurochem 136: 971-980.

Huang C, Sakry D, Menzel L, Dangel L, Sebastiani A, Kramer T, Karram K, Engelhard K, Trotter J, and Schafer MK. 2016. Lack of NG2 exacerbates neurological outcome and modulates glial responses after traumatic brain injury. Glia 64: 507-523.

Hohlfeld R, Dornmair K, Meinl E, and Wekerle H. 2016. The search for the target antigens of multiple sclerosis, part 2: CD8+ T cells, B cells, and antibodies in the focus of reverse-translational research. Lancet Neurol 15: 317-331.

Gross CC, Schulte-Mecklenbeck A, Klinsing S, Posevitz-Fejfar A, Wiendl H, and Klotz L. 2016. Dimethyl fumarate treatment alters circulating T helper cell subsets in multiple sclerosis. Neurol Neuroimmunol Neuroinflamm 3: e183.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Zimmermann H, Droby A, Steinmetz H, Zipp F, Deichmann R, and Klein JC. 2016. Assessment of cortical damage in early multiple sclerosis with quantitative T relaxometry. NMR Biomed 29: 444-450.

Baudrexel S, Reitz SC, Hof S, Gracien RM, Fleischer V, Zimmermann H, Droby A, Klein JC, and Deichmann R. 2016. Quantitative T and proton density mapping with direct calculation of radiofrequency coil transmit and receive profiles from two-point variable flip angle data. NMR Biomed.

2015

Wuhrer M, Selman MH, McDonnell LA, Kumpfel T, Derfuss T, Khademi M, Olsson T, Hohlfeld R, Meinl E, and Krumbholz M. 2015. Pro-inflammatory pattern of IgG1 Fc glycosylation in multiple sclerosis cerebrospinal fluid. J Neuroinflammation 12: 235.

Schwab N, Schneider-Hohendorf T, and Wiendl H. 2015. Trafficking of lymphocytes into the CNS. Oncotarget 6: 17863-17864.

Schwab N, Schneider-Hohendorf T, Pignolet B, Spadaro M, Gorlich D, Meinl I, Windhagen S, Tackenberg B, Breuer J, Canto E, Kumpfel T, Hohlfeld R, Siffrin V, Luessi F, Posevitz-Fejfar A, Montalban X, Meuth SG, Zipp F, Gold R, Du Pasquier RA, Kleinschnitz C, Jacobi A, Comabella M, Bertolotto A, Brassat D, and Wiendl H. 2015. PML risk stratification using anti-JCV antibody index and L-selectin. Mult Scler22(8):1048-60.

Maus F, Sakry D, Biname F, Karram K, Rajalingam K, Watts C, Heywood R, Kruger R, Stegmuller J, Werner HB, Nave KA, Kramer-Albers EM, and Trotter J. 2015. The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2. PLoS ONE 10: e0137311.

Kramer J, Meuth SG, Tenberge JG, Schiffler P, Wiendl H, and Deppe M. 2015. Early and Degressive Putamen Atrophy in Multiple Sclerosis. Int J Mol Sci 16: 23195-23209.

Knier B, Berthele A, Buck D, Schmidt P, Zimmer C, Muhlau M, Hemmer B, and Korn T. 2015. Optical coherence tomography indicates disease activity prior to clinical onset of central nervous system demyelination. Mult Scler 22(7):893-900.

Hucke S, Wiendl H, and Klotz L. 2015. Implications of dietary salt intake for multiple sclerosis pathogenesis. Mult Scler 22(2):133-9

Hucke S, Eschborn M, Liebmann M, Herold M, Freise N, Engbers A, Ehling P, Meuth SG, Roth J, Kuhlmann T, Wiendl H, and Klotz L. 2015. Sodium chloride promotes pro-inflammatory macrophage polarization thereby aggravating CNS autoimmunity. J Autoimmun 67:90-101.

Hohlfeld R, and Wekerle H. 2015. [Multiple sclerosis and microbiota. From genome to metagenome?]. Nervenarzt 86: 925-933.

Hohlfeld R, Dornmair K, Meinl E, and Wekerle H. 2015. The search for the target antigens of multiple sclerosis, part 1: autoreactive CD4+ T lymphocytes as pathogenic effectors and therapeutic targets. Lancet Neurol 15(2):198-209.

Hoffmann FS, Hofereiter J, Rubsamen H, Melms J, Schwarz S, Faber H, Weber P, Putz B, Loleit V, Weber F, Hohlfeld R, Meinl E, and Krumbholz M. 2015. Fingolimod induces neuroprotective factors in human astrocytes. J Neuroinflammation 12: 184.

Herold M, Posevitz V, Chudyka D, Hucke S, Gross C, Kurth F, Leder C, Loser K, Kurts C, Knolle P, Klotz L, and Wiendl H. 2015. B7-H1 Selectively Controls TH17 Differentiation and Central Nervous System Autoimmunity via a Novel Non-PD-1-Mediated Pathway. J Immunol 195: 3584-3595.

Held K, Beltran E, Moser M, Hohlfeld R, and Dornmair K. 2015. T-cell receptor repertoire of human peripheral CD161hiTRAV1-2+ MAIT cells revealed by next generation sequencing and single cell analysis. Hum Immunol 76: 607-614.

Held K, Beltran E, Moser M, Hohlfeld R, and Dornmair K. 2015. T-cell receptor repertoire of human peripheral CD161(hi)TRAV1-2(+) MAIT cells revealed by next generation sequencing and single cell analysis. Hum Immunol 76: 607-614.

Haghikia A, Jorg S, Duscha A, Berg J, Manzel A, Waschbisch A, Hammer A, Lee DH, May C, Wilck N, Balogh A, Ostermann AI, Schebb NH, Akkad DA, Grohme DA, Kleinewietfeld M, Kempa S, Thone J, Demir S, Muller DN, Gold R, and Linker RA. 2015. Dietary Fatty Acids Directly Impact Central Nervous System Autoimmunity via the Small Intestine. Immunity 43: 817-829.

Gracien RM, Reitz SC, Hof SM, Fleischer V, Zimmermann H, Droby A, Steinmetz H, Zipp F, Deichmann R, and Klein JC. 2015. Changes and variability of proton density and T1 relaxation times in early multiple sclerosis: MRI markers of neuronal damage in the cerebral cortex. Eur Radiol26(8):2578-86

Gliem M, Klotz L, van Rooijen N, Hartung HP, and Jander S. 2015. Hyperglycemia and PPARgamma Antagonistically Influence Macrophage Polarization and Infarct Healing After Ischemic Stroke. Stroke 46: 2935-2942.

Droby A, Yuen KS, Muthuraman M, Reitz SC, Fleischer V, Klein J, Gracien RM, Ziemann U, Deichmann R, Zipp F, and Groppa S. 2015. Changes in brain functional connectivity patterns are driven by an individual lesion in MS: a resting-state fMRI study. Brain Imaging Behav 10(4):1117-1126

Maus F, Sakry D, Biname F, Karram K, Rajalingam K, Watts C, Heywood R, Kruger R, Stegmuller J, Werner HB, Nave KA, Kramer-Albers EM, and Trotter J. 2015. The NG2 Proteoglycan Protects Oligodendrocyte Precursor Cells against Oxidative Stress via Interaction with OMI/HtrA2. PLoS One 10: e0137311.

Wiendl H, Elger C, Forstl H, Hartung HP, Oertel W, Reichmann H, and Schwab S. 2015. Gaps Between Aims and Achievements in Therapeutic Modification of Neuronal Damage (“Neuroprotection”). Neurotherapeutics 12: 449-454.

Warnke C, Stettner M, Lehmensiek V, Dehmel T, Mausberg AK, von Geldern G, Gold R, Kumpfel T, Hohlfeld R, Maurer M, Stangel M, Straeten V, Limmroth V, Weber T, Kleinschnitz C, Wattjes MP, Svenningsson A, Olsson T, Hartung HP, Hermsen D, Tumani H, Adams O, and Kieseier BC. 2015. Natalizumab exerts a suppressive effect on surrogates of B cell function in blood and CSF. Mult Scler 21: 1036-1044.

Walsh JT, Hendrix S, Boato F, Smirnov I, Zheng J, Lukens JR, Gadani S, Hechler D, Golz G, Rosenberger K, Kammertons T, Vogt J, Vogelaar C, Siffrin V, Radjavi A, Fernandez-Castaneda A, Gaultier A, Gold R, Kanneganti TD, Nitsch R, Zipp F, and Kipnis J. 2015. MHCII-independent CD4+ T cells protect injured CNS neurons via IL-4. J Clin Invest 125: 699-714.

Waisman A, Liblau R, and Becher B. 2015. Innate and adaptive immune responses in the CNS. The Lancet Neurology 14: 945-955.

Waisman A, Hauptmann J, and Regen T. 2015. The role of IL-17 in CNS diseases. Acta Neuropathol 129: 625-637.

Vestweber D. 2015. Cadherins in tissue architecture and disease. J Mol Med (Berl) 93: 5-11.

Ulges A, Klein M, Reuter S, Gerlitzki B, Hoffmann M, Grebe N, Staudt V, Stergiou N, Bohn T, Bruhl TJ, Muth S, Yurugi H, Rajalingam K, Bellinghausen I, Tuettenberg A, Hahn S, Reissig S, Haben I, Zipp F, Waisman A, Probst HC, Beilhack A, Buchou T, Filhol-Cochet O, Boldyreff B, Breloer M, Jonuleit H, Schild H, Schmitt E, and Bopp T. 2015. Protein kinase CK2 enables regulatory T cells to suppress excessive TH2 responses in vivo. Nat Immunol 16: 267-275.

Spadaro M, Gerdes LA, Mayer MC, Ertl-Wagner B, Laurent S, Krumbholz M, Breithaupt C, Hogen T, Straube A, Giese A, Hohlfeld R, Lassmann H, Meinl E, and Kumpfel T. 2015. Histopathology and clinical course of MOG-antibody-associated encephalomyelitis. Ann Clin Transl Neurol 2: 295-301.

Song J, Wu C, Korpos E, Zhang X, Agrawal SM, Wang Y, Faber C, Schafers M, Korner H, Opdenakker G, Hallmann R, and Sorokin L. 2015. Focal MMP-2 and MMP-9 activity at the blood-brain barrier promotes chemokine-induced leukocyte migration. Cell Rep 10: 1040-1054.

Siffrin V, Birkenstock J, Luchtman DW, Gollan R, Baumgart J, Niesner RA, Griesbeck O, and Zipp F. 2015. FRET based ratiometric Ca(2+) imaging to investigate immune-mediated neuronal and axonal damage processes in experimental autoimmune encephalomyelitis. J Neurosci Methods 249: 8-15.

Schwab N, Schneider-Hohendorf T, and Wiendl H. 2015. Therapeutic uses of anti-alpha4-integrin (anti-VLA-4) antibodies in multiple sclerosis. Int Immunol 27: 47-53.

Sakry D, and Trotter J. 2015. The role of the NG2 proteoglycan in OPC and CNS network function. Brain Res.

Rumble JM, Huber AK, Krishnamoorthy G, Srinivasan A, Giles DA, Zhang X, Wang L, and Segal BM. 2015. Neutrophil-related factors as biomarkers in EAE and MS. J Exp Med 212: 23-35.

Reuter E, Gollan R, Grohmann N, Paterka M, Salmon H, Birkenstock J, Richers S, Leuenberger T, Brandt AU, Kuhlmann T, Zipp F, and Siffrin V. 2015. Cross-recognition of a myelin peptide by CD8+ T cells in the CNS is not sufficient to promote neuronal damage. J Neurosci 35: 4837-4850.

Reissig S, Hovelmeyer N, Tang Y, Weih D, Nikolaev A, Riemann M, Weih F, and Waisman A. 2015. The deubiquitinating enzyme CYLD regulates the differentiation and maturation of thymic medullary epithelial cells. Immunol Cell Biol 93: 558-566.

Preisner A, Albrecht S, Cui QL, Hucke S, Ghelman J, Hartmann C, Taketo MM, Antel J, Klotz L, and Kuhlmann T. 2015. Non-steroidal anti-inflammatory drug indometacin enhances endogenous remyelination. Acta Neuropathol 130: 247-261.

Nemecek A, Zimmermann H, Rubenthaler J, Fleischer V, Paterka M, Luessi F, Muller-Forell W, Zipp F, and Siffrin V. 2015. Flow cytometric analysis of T cell/monocyte ratio in clinically isolated syndrome identifies patients at risk of rapid disease progression. Mult Scler.

Luessi F, Kraus S, Trinschek B, Lerch S, Ploen R, Paterka M, Roberg T, Poisa-Beiro L, Klotz L, Wiendl H, Bopp T, Jonuleit H, Jolivel V, Zipp F, and Witsch E. 2015. FTY720 (fingolimod) treatment tips the balance towards less immunogenic antigen-presenting cells in patients with multiple sclerosis. Mult Scler.

Lindner M, Thummler K, Arthur A, Brunner S, Elliott C, McElroy D, Mohan H, Williams A, Edgar JM, Schuh C, Stadelmann C, Barnett SC, Lassmann H, Mucklisch S, Mudaliar M, Schaeren-Wiemers N, Meinl E, and Linington C. 2015. Fibroblast growth factor signalling in multiple sclerosis: inhibition of myelination and induction of pro-inflammatory environment by FGF9. Brain 138: 1875-1893.

Laurent SA, Hoffmann FS, Kuhn PH, Cheng Q, Chu Y, Schmidt-Supprian M, Hauck SM, Schuh E, Krumbholz M, Rubsamen H, Wanngren J, Khademi M, Olsson T, Alexander T, Hiepe F, Pfister HW, Weber F, Jenne D, Wekerle H, Hohlfeld R, Lichtenthaler SF, and Meinl E. 2015. gamma-Secretase directly sheds the survival receptor BCMA from plasma cells. Nat Commun 6: 7333.

Kurschus FC. 2015. T cell mediated pathogenesis in EAE: Molecular mechanisms. Biomed J 38: 183-193.

Kramer J, Deppe M, Gobel K, Tabelow K, Wiendl H, and Meuth SG. 2015. Recovery of thalamic microstructural damage after Shiga toxin 2-associated hemolytic-uremic syndrome. J Neurol Sci 356: 175-183.

Kowarik MC, Dzieciatkowska M, Wemlinger S, Ritchie AM, Hemmer B, Owens GP, and Bennett JL. 2015. The cerebrospinal fluid immunoglobulin transcriptome and proteome in neuromyelitis optica reveals central nervous system-specific B cell populations. J Neuroinflammation 12: 19.

Knier B, Rothhammer V, Heink S, Puk O, Graw J, Hemmer B, and Korn T. 2015. Neutralizing IL-17 protects the optic nerve from autoimmune pathology and prevents retinal nerve fiber layer atrophy during experimental autoimmune encephalomyelitis. J Autoimmun 56: 34-44.

Hoppmann N, Graetz C, Paterka M, Poisa-Beiro L, Larochelle C, Hasan M, Lill CM, Zipp F, and Siffrin V. 2015. New candidates for CD4 T cell pathogenicity in experimental neuroinflammation and multiple sclerosis. Brain 138: 902-917.

Hohlfeld R, and Wekerle H. 2015. [Multiple sclerosis and microbiota : From genome to metagenome?]. Nervenarzt 86: 925-933.

Hoffmann FS, Kuhn PH, Laurent SA, Hauck SM, Berer K, Wendlinger SA, Krumbholz M, Khademi M, Olsson T, Dreyling M, Pfister HW, Alexander T, Hiepe F, Kumpfel T, Crawford HC, Wekerle H, Hohlfeld R, Lichtenthaler SF, and Meinl E. 2015. The immunoregulator soluble TACI is released by ADAM10 and reflects B cell activation in autoimmunity. J Immunol 194: 542-552.

Hemmer B, Kerschensteiner M, and Korn T. 2015. Role of the innate and adaptive immune responses in the course of multiple sclerosis. Lancet Neurol 14: 406-419.

Held K, Bhonsle-Deeng L, Siewert K, Sato W, Beltran E, Schmidt S, Ruhl G, Ng JK, Engerer P, Moser M, Klinkert WE, Babbe H, Misgeld T, Wekerle H, Laplaud DA, Hohlfeld R, and Dornmair K. 2015. alphabeta T-cell receptors from multiple sclerosis brain lesions show MAIT cell-related features. Neurol Neuroimmunol Neuroinflamm 2: e107.

Hallmann R, Zhang X, Di Russo J, Li L, Song J, Hannocks MJ, and Sorokin L. 2015. The regulation of immune cell trafficking by the extracellular matrix. Curr Opin Cell Biol 36: 54-61.

Grutzke B, Hucke S, Gross CC, Herold MV, Posevitz-Fejfar A, Wildemann BT, Kieseier BC, Dehmel T, Wiendl H, and Klotz L. 2015. Fingolimod treatment promotes regulatory phenotype and function of B cells. Ann Clin Transl Neurol 2: 119-130.

Gobel K, Bittner S, Cerina M, Herrmann AM, Wiendl H, and Meuth SG. 2015. An ex vivo model of an oligodendrocyte-directed T-cell attack in acute brain slices. J Vis Exp.

Ehrlich M, Hallmann AL, Reinhardt P, Arauzo-Bravo MJ, Korr S, Ropke A, Psathaki OE, Ehling P, Meuth SG, Oblak AL, Murrell JR, Ghetti B, Zaehres H, Scholer HR, Sterneckert J, Kuhlmann T, and Hargus G. 2015. Distinct Neurodegenerative Changes in an Induced Pluripotent Stem Cell Model of Frontotemporal Dementia Linked to Mutant TAU Protein. Stem Cell Reports 5: 83-96.

Droby A, Lukas C, Schanzer A, Spiwoks-Becker I, Giorgio A, Gold R, De Stefano N, Kugel H, Deppe M, Wiendl H, Meuth SG, Acker T, Zipp F, and Deichmann R. 2015. A human post-mortem brain model for the standardization of multi-centre MRI studies. Neuroimage 110: 11-21.

Droby A, Fleischer V, Carnini M, Zimmermann H, Siffrin V, Gawehn J, Erb M, Hildebrandt A, Baier B, and Zipp F. 2015. The impact of isolated lesions on white-matter fiber tracts in multiple sclerosis patients. Neuroimage Clin 8: 110-116.

Deppe M, Tabelow K, Kramer J, Tenberge JG, Schiffler P, Bittner S, Schwindt W, Zipp F, Wiendl H, and Meuth SG. 2015. Evidence for early, non-lesional cerebellar damage in patients with multiple sclerosis: DTI measures correlate with disability, atrophy, and disease duration. Mult Scler.

Bruttger J, Karram K, Wortge S, Regen T, Marini F, Hoppmann N, Klein M, Blank T, Yona S, Wolf Y, Mack M, Pinteaux E, Muller W, Zipp F, Binder H, Bopp T, Prinz M, Jung S, and Waisman A. 2015. Genetic Cell Ablation Reveals Clusters of Local Self-Renewing Microglia in the Mammalian Central Nervous System. Immunity 43: 92-106.

Bista P, Pawlowski M, Cerina M, Ehling P, Leist M, Meuth P, Aissaoui A, Borsotto M, Heurteaux C, Decher N, Pape HC, Oliver D, Meuth SG, and Budde T. 2015. Differential phospholipase C-dependent modulation of TASK and TREK two-pore domain K+ channels in rat thalamocortical relay neurons. J Physiol 593: 127-144.

2014

Luessi F, Kuhlmann T, and Zipp F. 2014. Remyelinating strategies in multiple sclerosis. Expert Rev Neurother 14: 1315-1334.

Warnke C, von Geldern G, Markwerth P, Dehmel T, Hoepner R, Gold R, Pawlita M, Kumpfel T, Maurer M, Stangel M, Wegner F, Hohlfeld R, Straeten V, Limmroth V, Weber T, Hermsen D, Kleinschnitz C, Hartung HP, Wattjes MP, Svenningson A, Major E, Olsson T, Kieseier BC, and Adams O. 2014. Cerebrospinal fluid JC virus antibody index for diagnosis of natalizumab-associated progressive multifocal leukoencephalopathy. Ann Neurol 76: 792-801.

Takeda AN, Oberoi-Khanuja TK, Glatz G, Schulenburg K, Scholz RP, Carpy A, Macek B, Remenyi A, and Rajalingam K. 2014. Ubiquitin-dependent regulation of MEKK2/3-MEK5-ERK5 signaling module by XIAP and cIAP1. EMBO J 33: 1784-1801.

Sie C, Korn T, and Mitsdoerffer M. 2014. Th17 cells in central nervous system autoimmunity. Exp Neurol 262 Pt A: 18-27.

Shen P, Roch T, Lampropoulou V, O’Connor RA, Stervbo U, Hilgenberg E, Ries S, Dang VD, Jaimes Y, Daridon C, Li R, Jouneau L, Boudinot P, Wilantri S, Sakwa I, Miyazaki Y, Leech MD, McPherson RC, Wirtz S, Neurath M, Hoehlig K, Meinl E, Grutzkau A, Grun JR, Horn K, Kuhl AA, Dorner T, Bar-Or A, Kaufmann SH, Anderton SM, and Fillatreau S. 2014. IL-35-producing B cells are critical regulators of immunity during autoimmune and infectious diseases. Nature 507: 366-370.

Schneider-Hohendorf T, Rossaint J, Mohan H, Böning D, Breuer J, Kuhlmann T, Gross C, Flanagan K, Sorokin L, Vestweber D, Zarbock A, Schwab N, and Wiendl H. 2014. VLA-4 blockade promotes differential routes into human CNS involving PSGL-1 rolling of T cells and MCAM-adhesion of TH17 cells. Journal of Clinical Investigation 9: 1833-1846.

Schneider-Hohendorf T, Philipp K, Husstedt IW, Wiendl H, and Schwab N. 2014. Specific loss of cellular L-selectin on CD4(+) T cells is associated with progressive multifocal leukoencephalopathy development during HIV infection. AIDS 28: 793-795.

Schmitt E, Klein M, and Bopp T. 2014. Th9 cells, new players in adaptive immunity. Trends Immunol 35: 61-68.

Schirmer L, Srivastava R, Kalluri SR, Bottinger S, Herwerth M, Carassiti D, Srivastava B, Gempt J, Schlegel J, Kuhlmann T, Korn T, Reynolds R, and Hemmer B. 2014. Differential loss of KIR4.1 immunoreactivity in multiple sclerosis lesions. Ann Neurol 75: 810-828.

Schirmer L, Srivastava R, and Hemmer B. 2014. To look for a needle in a haystack: the search for autoantibodies in multiple sclerosis. Mult Scler 20: 271-279.

Sakry D, Neitz A, Singh J, Frischknecht R, Marongiu D, Biname F, Perera SS, Endres K, Lutz B, Radyushkin K, Trotter J, and Mittmann T. 2014. Oligodendrocyte precursor cells modulate the neuronal network by activity-dependent ectodomain cleavage of glial NG2. PLoS Biol 12: e1001993.

Rothhammer V, Muschaweckh A, Gasteiger G, Petermann F, Heink S, Busch DH, Heikenwalder M, Hemmer B, Drexler I, and Korn T. 2014. alpha4-integrins control viral meningoencephalitis through differential recruitment of T helper cell subsets. Acta Neuropathol Commun 2: 27.

Posevitz-Fejfar A, and Wiendl H. 2014. The neuroinflammation biobank in the Department of Neurology, University Hospital Muenster, Germany. Biopreserv Biobank 12: 74-75.

Posevitz-Fejfar A, Posevitz V, Gross CC, Bhatia U, Kurth F, Schutte V, Bar-Or A, Meuth SG, and Wiendl H. 2014. Effects of blood transportation on human peripheral mononuclear cell yield, phenotype and function: implications for immune cell biobanking. PLoS One 9: e115920.

Mohan H, Friese A, Albrecht S, Krumbholz M, Elliott CL, Arthur A, Menon R, Farina C, Junker A, Stadelmann C, Barnett SC, Huitinga I, Wekerle H, Hohlfeld R, Lassmann H, Kuhlmann T, Linington C, and Meinl E. 2014. Transcript profiling of different types of multiple sclerosis lesions yields FGF1 as a promoter of remyelination. Acta Neuropathol Commun 2: 168.

Luchtman DW, Ellwardt E, Larochelle C, and Zipp F. 2014. IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: Current and future developments. Cytokine Growth Factor Rev 25: 403-413.

Kraus SH, Luessi F, Trinschek B, Lerch S, Hubo M, Poisa-Beiro L, Paterka M, Jonuleit H, Zipp F, and Jolivel V. 2014. Cladribine exerts an immunomodulatory effect on human and murine dendritic cells. Int Immunopharmacol 18: 347-357.

Korn T. 2014. How do Th17 cells mediate autoimmune inflammation in the central nervous system?. Clinical and Experimental Neuroimmunology 5: 120-131.

Hovelmeyer N, Worns MA, Reissig S, Adams-Quack P, Leclaire J, Hahn M, Wortge S, Nikolaev A, Galle PR, and Waisman A. 2014. Overexpression of Bcl-3 inhibits the development of marginal zone B cells. Eur J Immunol 44: 545-552.

Hoffmann F, and Meinl E. 2014. B cells in multiple sclerosis: good or bad guys?: An article for 28 May 2014 – World MS Day 2014. Eur J Immunol 44: 1247-1250.

Heinen AP, Wanke F, Moos S, Attig S, Luche H, Pal PP, Budisa N, Fehling HJ, Waisman A, and Kurschus FC. 2014. Improved method to retain cytosolic reporter protein fluorescence while staining for nuclear proteins. Cytometry A 85: 621-627.

Heinemann C, Heink S, Petermann F, Vasanthakumar A, Rothhammer V, Doorduijn E, Mitsdoerffer M, Sie C, Prazeres da Costa O, Buch T, Hemmer B, Oukka M, Kallies A, and Korn T. 2014. IL-27 and IL-12 oppose pro-inflammatory IL-23 in CD4+ T cells by inducing Blimp1. Nat Commun 5: 3770.

Hargus G, Ehrlich M, Arauzo-Bravo MJ, Hemmer K, Hallmann AL, Reinhardt P, Kim KP, Adachi K, Santourlidis S, Ghanjati F, Fauser M, Ossig C, Storch A, Kim JB, Schwamborn JC, Sterneckert J, Scholer HR, Kuhlmann T, and Zaehres H. 2014. Origin-dependent neural cell identities in differentiated human iPSCs in vitro and after transplantation into the mouse brain. Cell Rep 8: 1697-1703.

Gritsch S, Lu J, Thilemann S, Wortge S, Mobius W, Bruttger J, Karram K, Ruhwedel T, Blanfeld M, Vardeh D, Waisman A, Nave KA, and Kuner R. 2014. Oligodendrocyte ablation triggers central pain independently of innate or adaptive immune responses in mice. Nat Commun 5: 5472.

Gonsior C, Biname F, Fruhbeis C, Bauer NM, Hoch-Kraft P, Luhmann HJ, Trotter J, and White R. 2014. Oligodendroglial p130Cas is a target of Fyn kinase involved in process formation, cell migration and survival. PLoS One 9: e89423.

Gewies A, Gorka O, Bergmann H, Pechloff K, Petermann F, Jeltsch KM, Rudelius M, Kriegsmann M, Weichert W, Horsch M, Beckers J, Wurst W, Heikenwalder M, Korn T, Heissmeyer V, and Ruland J. 2014. Uncoupling Malt1 threshold function from paracaspase activity results in destructive autoimmune inflammation. Cell Rep 9: 1292-1305.

Deppe M, Marinell J, Kramer J, Duning T, Ruck T, Simon OJ, Zipp F, Wiendl H, and Meuth SG. 2014. Increased cortical curvature reflects white matter atrophy in individual patients with early multiple sclerosis. Neuroimage Clin 6: 475-487.

Croxford AL, Karbach S, Kurschus FC, Wortge S, Nikolaev A, Yogev N, Klebow S, Schuler R, Reissig S, Piotrowski C, Brylla E, Bechmann I, Scheller J, Rose-John S, Wunderlich FT, Munzel T, von Stebut E, and Waisman A. 2014. IL-6 regulates neutrophil microabscess formation in IL-17A-driven psoriasiform lesions. J Invest Dermatol 134: 728-735.

Chen H, Assmann JC, Krenz A, Rahman M, Grimm M, Karsten CM, Kohl J, Offermanns S, Wettschureck N, and Schwaninger M. 2014. Hydroxycarboxylic acid receptor 2 mediates dimethyl fumarate’s protective effect in EAE. J Clin Invest 124: 2188-2192.

Bittner S, Ruck T, Fernandez-Orth J, and Meuth SG. 2014. TREK-king the blood-brain-barrier. J Neuroimmune Pharmacol 9: 293-301.

Berer K, and Krishnamoorthy G. 2014. Microbial view of central nervous system autoimmunity. FEBS Lett 588: 4207-4213.

Berer K, Boziki M, and Krishnamoorthy G. 2014. Selective accumulation of pro-inflammatory T cells in the intestine contributes to the resistance to autoimmune demyelinating disease. PLoS One 9: e87876.

Beltran E, Obermeier B, Moser M, Coret F, Simo-Castello M, Bosca I, Perez-Miralles F, Villar LM, Senel M, Tumani H, Hohlfeld R, Casanova B, and Dornmair K. 2014. Intrathecal somatic hypermutation of IgM in multiple sclerosis and neuroinflammation. Brain 137: 2703-2714.

2013

Zipp F, Gold R, and Wiendl H. 2013. Identification of inflammatory neuronal injury and prevention of neuronal damage in multiple sclerosis: hope for novel therapies?. JAMA Neurol 70: 1569-1574.

Zayoud M, El Malki K, Frauenknecht K, Trinschek B, Kloos L, Karram K, Wanke F, Georgescu J, Hartwig UF, Sommer C, Jonuleit H, Waisman A, and Kurschus FC. 2013. Subclinical CNS inflammation as response to a myelin antigen in humanized mice. J Neuroimmune Pharmacol 8: 1037-1047.

Wiendl H, and Gross CC. 2013. Modulation of IL-2Ralpha with daclizumab for treatment of multiple sclerosis. Nat Rev Neurol 9: 394-404.

Wekerle H, Berer K, and Krishnamoorthy G. 2013. Remote control-triggering of brain autoimmune disease in the gut. Curr Opin Immunol 25: 683-689.

Stangel M, Fredrikson S, Meinl E, Petzold A, Stuve O, and Tumani H. 2013. The utility of cerebrospinal fluid analysis in patients with multiple sclerosis. Nat Rev Neurol 9: 267-276.

Schwab N, Schneider-Hohendorf T, Posevitz V, Breuer J, Gobel K, Windhagen S, Brochet B, Vermersch P, Lebrun-Frenay C, Posevitz-Fejfar A, Capra R, Imberti L, Straeten V, Haas J, Wildemann B, Havla J, Kumpfel T, Meinl I, Niessen K, Goelz S, Kleinschnitz C, Warnke C, Buck D, Gold R, Kieseier BC, Meuth SG, Foley J, Chan A, Brassat D, and Wiendl H. 2013. L-selectin is a possible biomarker for individual PML risk in natalizumab-treated MS patients. Neurology 81: 865-871.

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Lindner M, Ng JK, Hochmeister S, Meinl E, and Linington C. 2013. Neurofascin 186 specific autoantibodies induce axonal injury and exacerbate disease severity in experimental autoimmune encephalomyelitis. Exp Neurol 247: 259-266.

Liblau RS, Gonzalez-Dunia D, Wiendl H, and Zipp F. 2013. Neurons as targets for T cells in the nervous system. Trends Neurosci 36: 315-324.

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Hucke S, Wiendl H, Knolle P, and Klotz L. 2013. Nuclear receptor control of myeloid cell responses—implications for CNS autoimmunity. Rheumatology 3: 1-12.

Havla J, Tackenberg B, Hellwig K, Meinl I, Krumbholz M, Seitz F, Eienbroker C, Gold R, Hohlfeld R, Kleiter I, and Kumpfel T. 2013. Fingolimod reduces recurrence of disease activity after natalizumab withdrawal in multiple sclerosis. J Neurol 260: 1382-1387.

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2012

Krumbholz M, Derfuss T, Hohlfeld R, and Meinl E. 2012. B cells and antibodies in multiple sclerosis pathogenesis and therapy. Nat Rev Neurol 8: 613-623.

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