Gut microbiome metabolites in MS inflammation and neurodegeneration

A01

The involvement of nutrition and dietary habits, e.g. the Western diet in MS disease pathogenesis, has only recently become ever more evident. However there is an unmet need for understanding the functional impact of the gut microbiome on disease etiology, pathogenesis, and therapy. We had previously identified fatty acids as metabolites that are linked with the gut associated immune response in the context of MS. In contrast to long chain fatty acids, short chain fatty acids (SCFA) lead to increased differentiation of anti-inflammatory regulatory T cells (Treg), and to a significant amelioration of disease severity in the EAE by daily supplementation with propionic acid (PA). The results of our project clearly indicate that the systemic effect of gut microbiome metabolites on both, immune cells and cells of the enteric/central nervous system, needs to be investigated in more detail. Our main questions are:

    1. Does PA have a direct neuroprotective/neuroregenerative impact? If so, what are the mechanisms?
    2. What are the range of effects of PA on the gut tissue? Are other immune cell subsets affected, i.e. resident myeloid cells?
    3. Does long-term PA supplementation lead to a reversal of MS associated gut microbiome changes (towards healthy controls)?
    4. Which metabolic factors in the gut are altered in response to PA supplementation?

 

 

 

 

 

 

 

 

 

 

 

Principal Investigators:

Univ.-Prof. Dr. med. Aiden Haghikia
Universitätsklinik für Neurologie
Magdeburg
aiden.haghikia@med.ovgu.de

Univ.-Prof. Dr. med. Ralf Gold
Universitätsklinik für Neurologie
Bochum
ralf.gold@rub.de

News

Mon, 20/09/2021
Register now: 1st Symposium inflammation and imaging
When?: from November 2nd to November 4th 2021 Where?: Schloss (seat of the University Administration) Muenster Organizers: Co-operative Research Centres 1009, 1450, Transregio 128, and Clinical Research Unit 342 – together with Interdisciplinary Centre of Clinical Research (IZKF) and Excellence Cluster Cells in Motion (CiM) Registration is open now! More information: here...more
Mon, 09/08/2021
Dietary conjugated linoleic acid links reduced intestinal inflammation to amelioration of CNS autoimmunity
A close interaction between gut immune responses and distant organ-specific autoimmunity including the CNS in multiple sclerosis has been established in recent years. This so-called gut-CNS axis can be shaped by dietary factors, either directly or via indirect modulation of the gut microbiome and its metabolites. Here, SFB 128 PI Luisa Klotz and colleagues report […]...more
Thu, 28/01/2021
BioNTech Publishes Data on Novel mRNA Vaccine Approach to Treat Autoimmune Diseases in Science
BioNTech SE (Nasdaq: BNTX, “BioNTech” or “the Company”) announced the publication of preclinical data on its novel mRNA vaccine approach against autoimmune diseases in the peer-reviewed journal Science. The publication titled “A non-inflammatory mRNA vaccine for treatment of experimental autoimmune encephalomyelitis” co-authored by SFB principal investigator Ari Waisman summarizes the findings on the disease-suppressing effects […]...more