Tue, 10/07/2018
SFB offers workshop on Bioinformatics
Mainz. SFB Associate Muthuraman Muthuraman cordially invites all members to the “Bioinformatics Workshop” on Monday, September 24, 2018. The one-day event combines lectures on topics such as “Machine learning and statistics”, “Bioinformatics analyses of multi parameter flow cytometry data” and “Computational System Genetics” with a hands-on session. The full program is available here....more
Tue, 05/06/2018
21st Meeting on T-Cells, Subsets and Functions
Marburg. SFB-PI Prof. Dr. Tobias Bopp & Prof. Dr. Magdalena Huber are chairing this year’s “21st Meeting on T-Cells, Subsets and Functions“ in Marburg. The two-day conference covers all recent aspects of T cell subsets, including Th1, Zh2, Th17, CD8 NKT and regulatory T cells When?: Thursday, June 21, 12.00 – 8.00 PM and Wednesday, […]...more
Fri, 25/05/2018
SFB/CRC-TR 128 retreat in Munich
Munich. The CRC-TR 128 “Multiple Sclerosis” cordially invites all its members – principal investigators as well as associated scientists and young investigators – to meet for a general scientific update, discussion and exchange at this year’s retreat. In addition to the PI meeting there will be a one-day conference especially for young investigators. When?: Thursday […]...more

Wed, 23/11/2016 | Featured publication: Imaging matrix metalloproteinase activity in multiple sclerosis as a specific marker of leukocyte penetration of the blood-brain barrier

Münster – The enzymes gelatinase A/matrix metalloproteinase-2 (MMP-2) and gelatinase B/MMP-9 are essential for induction of neuroinflammatory symptoms in experimental autoimmune encephalomyelitis (EAE), a mouse model of multiple sclerosis (MS). In the absence of these enzymes, the disease does not develop. SFB128 scientists of Prof. Dr. Lydia Sorokin’s group, therefore, investigated the cellular sources and relative contributions of MMP-2 and MMP-9 to disease at early stages of EAE induction. They demonstrated that MMP-9 from an immune cell source is required in EAE for initial infiltration of leukocytes into the central nervous system and that MMP-9 activity is a reliable marker of leukocyte penetration of the blood-brain barrier.
The neuroscientists then developed a molecular imaging method to visualize MMP activity in the brain using fluorescent- and radioactive-labeled MMP inhibitors (MMPis).
By using radioactive MMP ligand in EAE animals the Muenster neuroscientists produced positron emission tomography (PET) images of MMP activity in patients with MS.
In contrast to traditional T1-gadolinium contrast-enhanced MRI, MMPi-PET enabled tracking of MMP activity as a unique feature of early lesions and ongoing leukocyte infiltration.
MMPi-PET therefore allows monitoring of the early steps of MS development and provides sensitive, noninvasive means of following lesion formation and resolution in murine EAE and human MS, the neuroscientists conclude. Their work was part of the SFB projects B03 and Z02.