News

Wed, 22/11/2023
Hybrid seminar on ‘The origins and consequences of multiple slerosis’
Munich. Prof. Lars Fugger from the Nuffield Department of Clinical Neurosciences at the University of Oxford will give a hybrid seminar on ‘The origins and consequences of multiple slerosis’ in the large auditorium at the TranslaTUM in MUNICH. The talk is organized by the TRR 355 and will be streamed via the TRR 355 seminar […]...more
Wed, 23/08/2023
Neurology Webinar on human brain T cells in health and multiple sclerosis
Muenster. The SFB 128 is happy welcome Joost J.F.M. Smolders, MD, PhD , head of MS Center ErasMS and Neuroimmunology Brain (NIB) Research Group at the Department of Immunology of the Erasmus University Medical Center (Erasmus MC), as lecturer at the Muenster Neurology Webinar. His talk is entitled “Unique features of human brain T cells […]...more
Thu, 03/08/2023
New Date: Neurology Webinar – How much gut needs the brain
Muenster. In January 2024, Prof. Anne-Katrin Pröbstel, Head of the Interdisciplinary Autoimmune Clinic at the University Hospital of Basel, will visit Muenster to give insights into the microbiota-immune crosstalk in neuroonflammation. Her presentation – which ois part of the Muenster Neurology Webinar – will be live-streamed. Time: Wednesday, January 24, 2024 Place: Online at zoom. […]...more


Wed, 04/03/2020 | The brain is less immune-priviledged than we thought

Münster. Although the CNS is immune privileged, continuous search for pathogens and tumours by immune cells within the CNS is indispensable. Thus, distinct immune-cell populations also cross the blood–brain barrier independently of inflammation/under homeostatic conditions. It was previously shown that effector memory T cells populate healthy CNS parenchyma in humans and, independently, that CCR5-expressing lymphocytes as well as CCR5 ligands are enriched in the CNS of patients with multiple sclerosis. Apart from the recently described CD8+ CNS tissue-resident memory T cells, CRC researchers from Muenster identified a population of CD4+CCR5high effector memory cells as brain parenchyma-surveilling cells. In an interview with the German radio news channel NDR info they explain these latest insights. Listen to the radio report (in German):

Adapted from: Herich S, Schneider-Hohendorf T, Rohlmann A, Khaleghi Ghadiri M, Schulte-Mecklenbeck A, Zondler L, Janoschka C, Ostkamp P, Richter J, Breuer J, Dimitrov S, Rammensee HG, Grauer OM, Klotz L, Gross CC, Stummer W, Missler M, Zarbock A, Vestweber D, Wiendl H, Schwab N. Human CCR5high effector memory cells perform CNS parenchymal immune surveillance via GZMK-mediated transendothelial diapedesis. Brain.142(11):3411-3427.